Abstract:
:Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed in patients with schizophrenia and has been hypothesized to result from a deficit in the control of attention. Here, an attentional task and functional brain imaging were used to probe the neural correlates of increased RT-ISV in schizophrenia. Thirty patients and 30 age and sex matched controls performed the Eriksen flanker spatial attention task with concurrent measurement of brain activity using functional magnetic resonance imaging (fMRI). The behavioral measures included accuracy, mean, standard deviation of RT (RTSD), coefficient of variation of RT (RTCV) and ex-Gaussian model of RT distribution parameters (mu, sigma and tau). Larger mean RT and Ex-Gaussian mu was observed for patients compared to controls. The group difference was larger for incongruent (attentionally demanding) versus congruent trials confirming a deficit in the control of spatial attention for patients. Significant increase in RT-ISV measures (RTSD, sigma and tau) for patients compared to controls was observed and was not modulated by trial congruency. Attention modulation (congruency effect) resulted in activation of bilateral frontal and parietal areas that was not different between patients and controls. Right middle frontal, right superior temporal and bilateral cingulate areas were more active in controls compared to patients independent of congruency. Activation in ROIs extracted from attention (congruency) and group related areas correlated with RT-ISV measures (especially RTCV and tau). Hypo-activation of the right middle frontal area correlated with increased tau specifically in patients. Hypo-activity of the right prefrontal cortex predicted increased RT-ISV in schizophrenia. This effect was unrelated to the effects of spatial attention and might be linked to a deficit in the inhibitory control of action for these patients.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Panagiotaropoulou G,Thrapsanioti E,Pappa E,Grigoras C,Mylonas D,Karavasilis E,Velonakis G,Kelekis N,Smyrnis Ndoi
10.1016/j.nicl.2019.101853subject
Has Abstractpub_date
2019-01-01 00:00:00pages
101853issn
2213-1582pii
S2213-1582(19)30203-7journal_volume
23pub_type
杂志文章abstract:BACKGROUND:Chronic cyanosis in adults with congenital heart disease (CHD) may cause structural brain changes that could contribute to impaired neurological functioning. The extent of these changes has not been adequately characterized. HYPOTHESIS:We hypothesized that adults with cyanotic CHD would have widespread chan...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2013.12.011
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2016.09.023
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.02.014
更新日期:2017-02-20 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.08.005
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.06.009
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2017.06.009
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2017.04.001
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.06.020
更新日期:2016-07-02 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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abstract:INTRODUCTION:Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated. METHODS:Fifty-four mTBI patients (median age: 35 years, range 19-...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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journal_title:NeuroImage. Clinical
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更新日期:2016-11-03 00:00:00
abstract:Background:Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients. Currently, these are not available using conventional magnetic resonance imaging (MRI) sequences. The aim of this study was to determine whether diffusion MRI cou...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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abstract::Independent studies on major depressive disorder (MDD) and hypertension, suggest overlapping abnormalities in brain regions associated with emotional and autonomic processing. However, the unique and interactive effects of MDD and hypertension have never been studied in a single sample. Brain volume in these areas may...
journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.08.016
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journal_title:NeuroImage. Clinical
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更新日期:2020-12-24 00:00:00