当前位置： SCI文献检索 > NeuroImage-Clinical期刊下所有文献 > APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study.

Abstract：

:Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function. Therefore, we combined MRI-based morphometry, MRS-based NAA-assessment and quantitative histology of neurons and amyloid plaque load in the APPswe/PS1dE9 mouse model to determine the interrelationship between morphological changes, changes in neuron numbers and amyloid plaque load with reductions of NAA levels as marker of neuronal functional viability. The APPswe/PS1dE9 mouse showed an increase of Aβ plaques, loss of neurons and an impairment of NAA/Cr ratio, which however was not accompanied with brain atrophy. As brain atrophy is one main characteristic in human AD, conclusions from murine to human AD pathology should be drawn with caution.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Kuhla A,Rühlmann C,Lindner T,Polei S,Hadlich S,Krause BJ,Vollmar B,Teipel SJ

doi

10.1016/j.nicl.2017.06.009

subject

Has Abstract

pub_date

2017-06-09 00:00:00

pages

581-586

issn

2213-1582

pii

S2213-1582(17)30140-7

journal_volume

15

pub_type

杂志文章

相关文献

NeuroImage-Clinical文献大全
  • MRI and cognitive scores complement each other to accurately predict Alzheimer's dementia 2 to 7 years before clinical onset.

    abstract：BACKGROUND:Predicting cognitive decline and the eventual onset of dementia in patients with Mild Cognitive Impairment (MCI) is of high value for patient management and potential cohort enrichment in pharmaceutical trials. We used cognitive scores and MRI biomarkers from a single baseline visit to predict the onset of d...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102121

    authors： Zandifar A,Fonov VS,Ducharme S,Belleville S,Collins DL,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期：2020-01-01 00:00:00

  • Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is characterized by the formation of demyelinating lesions in the white matter (WM). However, the timecourse of the evolution of healthy white matter into fully demyelinated lesions in MS is not well understood. We use a recently proposed technique to examine magnetization transfer ratio (MTR) ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2014.06.009

    authors： Brown RA,Narayanan S,Arnold DL

    更新日期：2014-08-15 00:00:00

  • Quantifying patterns of brain activity: Distinguishing unaffected siblings from participants with ADHD and healthy individuals.

    abstract：:Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.06.020

    authors： Wolfers T,van Rooij D,Oosterlaan J,Heslenfeld D,Hartman CA,Hoekstra PJ,Beckmann CF,Franke B,Buitelaar JK,Marquand AF

    更新日期：2016-07-02 00:00:00

  • Impact of schizophrenia on anterior and posterior hippocampus during memory for complex scenes.

    abstract：OBJECTIVES:Hippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionatel...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.11.017

    authors： Ragland JD,Layher E,Hannula DE,Niendam TA,Lesh TA,Solomon M,Carter CS,Ranganath C

    更新日期：2016-11-17 00:00:00

  • Improving the detection of autism spectrum disorder by combining structural and functional MRI information.

    abstract：:Autism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detectio...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102181

    authors： Rakić M,Cabezas M,Kushibar K,Oliver A,Lladó X

    更新日期：2020-01-01 00:00:00

  • White matter and reading deficits after pediatric traumatic brain injury: A diffusion tensor imaging study.

    abstract：:Pediatric traumatic brain injury often results in significant long-term deficits in mastery of reading ability. This study aimed to identify white matter pathways that, when damaged, predicted reading deficits in children. Based on the dual-route model of word reading, we predicted that integrity of the inferior front...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.10.009

    authors： Johnson CP,Juranek J,Swank PR,Kramer L,Cox CS Jr,Ewing-Cobbs L

    更新日期：2015-10-19 00:00:00

  • Subclinical paranoid beliefs and enhanced neural response during processing of unattractive faces.

    abstract：:The perception of faces and consequent social inferences are fundamental for interpersonal communication. While facial expression is important for interindividual communication, constitutional and acquired features are crucial for basic emotions of attraction or repulsion. An emotional bias in face processing has been...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102269

    authors： Furger S,Stahnke A,Zengaffinen F,Federspiel A,Morishima Y,Papmeyer M,Wiest R,Dierks T,Strik W

    更新日期：2020-01-01 00:00:00

  • Relevance of brain lesion location for cognition in vascular mild cognitive impairment.

    abstract：BACKGROUND:Vascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) of moderate or severe extension on brain MRI is the hallmark of the VMCI. OBJECTIVE:To assess the clinical relevance of the frequen...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.nicl.2019.101789

    authors： Giorgio A,Di Donato I,De Leucio A,Zhang J,Salvadori E,Poggesi A,Diciotti S,Cosottini M,Ciulli S,Inzitari D,Pantoni L,Mascalchi M,Federico A,Dotti MT,De Stefano N,VMCI-Tuscany Study Group.

    更新日期：2019-01-01 00:00:00

  • Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families.

    abstract：:Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals wi...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102273

    authors： Jiang W,Duan K,Rootes-Murdy K,Hoekstra PJ,Hartman CA,Oosterlaan J,Heslenfeld D,Franke B,Buitelaar J,Arias-Vasquez A,Liu J,Turner JA

    更新日期：2020-01-01 00:00:00

  • Psychopathy is associated with shifts in the organization of neural networks in a large incarcerated male sample.

    abstract：:Psychopathy is a personality disorder defined by antisocial behavior paired with callousness, low empathy, and low interpersonal emotions. Psychopathic individuals reliably display complex atypicalities in emotion and attention processing that are evident when examining task performance, activation within specific neu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102083

    authors： Tillem S,Harenski K,Harenski C,Decety J,Kosson D,Kiehl KA,Baskin-Sommers A

    更新日期：2019-01-01 00:00:00

  • Brain connectivity tracks effects of chemotherapy separately from behavioral measures.

    abstract：:Several studies in cancer research have suggested that cognitive dysfunction following chemotherapy, referred to in lay terms as "chemobrain", is a serious problem. At present, the changes in integrative brain function that underlie such dysfunction remain poorly understood. Recent developments in neuroimaging suggest...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101654

    authors： Kardan O,Reuter-Lorenz PA,Peltier S,Churchill NW,Misic B,Askren MK,Jung MS,Cimprich B,Berman MG

    更新日期：2019-01-01 00:00:00

  • Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1.

    abstract：:Myotonic dystrophy type 1 (DM1) has a wide phenotypic spectrum and potentially may affect central nervous system with mild to severe involvement. Our aim was to investigate grey matter (GM) and white matter (WM) structural alterations in a sample of adult-onset DM1 patients and to evaluate relationship with clinical a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.06.011

    authors： Baldanzi S,Cecchi P,Fabbri S,Pesaresi I,Simoncini C,Angelini C,Bonuccelli U,Cosottini M,Siciliano G

    更新日期：2016-06-15 00:00:00

  • Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study.

    abstract：:Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This stu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.05.011

    authors： Yokoyama C,Kaiya H,Kumano H,Kinou M,Umekage T,Yasuda S,Takei K,Nishikawa M,Sasaki T,Nishimura Y,Hara N,Inoue K,Kaneko Y,Suzuki S,Tanii H,Okada M,Okazaki Y

    更新日期：2015-05-28 00:00:00

  • Preterm birth and structural brain alterations in early adulthood.

    abstract：:Alterations in cortical development and impaired neurodevelopmental outcomes have been described following very preterm (VPT) birth in childhood and adolescence, but only a few studies to date have investigated grey matter (GM) and white matter (WM) maturation in VPT samples in early adult life. Using voxel-based morp...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2014.08.005

    authors： Nosarti C,Nam KW,Walshe M,Murray RM,Cuddy M,Rifkin L,Allin MP

    更新日期：2014-08-13 00:00:00

  • Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.

    abstract：:Structural and functional changes in the olfactory system are increasingly implicated in the expression of PTSD. Still, very little is known about the neurobiological networks of trauma-related odor sensitivity or how they relate to other objective and subjective measures of olfaction and PTSD. The purpose of this stu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.09.018

    authors： Cortese BM,Schumann AY,Howell AN,McConnell PA,Yang QX,Uhde TW

    更新日期：2017-09-28 00:00:00

  • Neurocognitive and neuroanatomical maturation in the clinical high-risk states for psychosis: A pattern recognition study.

    abstract：BACKGROUND:Findings from neurodevelopmental studies indicate that adolescents with psychosis spectrum disorders have delayed neurocognitive performance relative to the maturational state of their healthy peers. Using machine learning, we generated a model of neurocognitive age in healthy adults and investigated whether...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.101624

    authors： Kambeitz-Ilankovic L,Haas SS,Meisenzahl E,Dwyer DB,Weiske J,Peters H,Möller HJ,Falkai P,Koutsouleris N

    更新日期：2019-01-01 00:00:00

  • The benefits of skull stripping in the normalization of clinical fMRI data.

    abstract：:Establishing a reliable correspondence between lesioned brains and a template is challenging using current normalization techniques. The optimum procedure has not been conclusively established, and a critical dichotomy is whether to use input data sets which contain skull signal, or whether skull signal should be remo...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.09.007

    authors： Fischmeister FP,Höllinger I,Klinger N,Geissler A,Wurnig MC,Matt E,Rath J,Robinson SD,Trattnig S,Beisteiner R

    更新日期：2013-09-30 00:00:00

  • Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment.

    abstract：BACKGROUND:Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent a possible source of impaired neurocognitive functioning and were analyzed in these patients. METHODS:Eig...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102287

    authors： Kocher M,Jockwitz C,Caspers S,Schreiber J,Farrher E,Stoffels G,Filss C,Lohmann P,Tscherpel C,Ruge MI,Fink GR,Shah NJ,Galldiks N,Langen KJ

    更新日期：2020-01-01 00:00:00

  • Identifying controllable cortical neural markers with machine learning for adaptive deep brain stimulation in Parkinson's disease.

    abstract：:The identification of oscillatory neural markers of Parkinson's disease (PD) can contribute not only to the understanding of functional mechanisms of the disorder, but may also serve in adaptive deep brain stimulation (DBS) systems. These systems seek online adaptation of stimulation parameters in closed-loop as a fun...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102376

    authors： Castaño-Candamil S,Piroth T,Reinacher P,Sajonz B,Coenen VA,Tangermann M

    更新日期：2020-01-01 00:00:00

  • Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer's disease.

    abstract：:We studied the dynamic functional connectivity profile of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) compared to controls, how it differs between the two dementia subtypes, and a possible relation between dynamic connectivity alterations and temporally transient clinical symptoms in DLB. Resting stat...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101812

    authors： Schumacher J,Peraza LR,Firbank M,Thomas AJ,Kaiser M,Gallagher P,O'Brien JT,Blamire AM,Taylor JP

    更新日期：2019-01-01 00:00:00

  • Neural correlates of cognitive function and symptoms in attention-deficit/hyperactivity disorder in adults.

    abstract：:While gray matter (GM) anomalies have been reported for attention-deficit/hyperactivity disorder (ADHD), investigating their associations with cognitive deficits and individual symptom domains can help pinpoint the neural underpinnings critical for the pathology of ADHD, particularly the persist form of ADHD. In this ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.04.035

    authors： Duan K,Chen J,Calhoun VD,Lin D,Jiang W,Franke B,Buitelaar JK,Hoogman M,Arias-Vasquez A,Turner JA,Liu J

    更新日期：2018-05-02 00:00:00

  • The neuropsychological profiles and semantic-critical regions of right semantic dementia.

    abstract：Introduction:Previous literature has revealed that the anterior temporal lobe (ATL) is the semantic hub of left-sided or mixed semantic dementia (SD), whilst the semantic hub of right-sided SD has not been examined. Methods:Seventeen patients with right-sided SD, 18 patients with left-sided SD and 20 normal controls (...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.05.035

    authors： Chen K,Ding J,Lin B,Huang L,Tang L,Bi Y,Han Z,Lv Y,Guo Q

    更新日期：2018-05-29 00:00:00

  • Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?

    abstract：:Biomarkers in whichever modality are tremendously important in diagnosing of disease, tracking disease progression and clinical trials. This applies in particular for disorders with a long disease course including pre-symptomatic stages, in which only subtle signs of clinical progression can be observed. Magnetic reso...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,评审

    doi：10.1016/j.nicl.2018.03.013

    authors： Hohenfeld C,Werner CJ,Reetz K

    更新日期：2018-03-16 00:00:00

  • Reduced neural specificity in middle-aged HIV+ women in the absence of behavioral deficits.

    abstract：:In the post combination antiretroviral therapy (cART) era, the prevalence of mild forms of HIV-associated neurocognitive disorders (HAND) in individuals with HIV-infection remains high. There is a pressing need to find biomarkers that can aid clinical assessment of HAND, especially in those with mild or no neurocognit...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2014.12.003

    authors： Liu C,Wang C,Leclair M,Young M,Jiang X

    更新日期：2014-12-13 00:00:00

  • Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes.

    abstract：Objective:To diagnose and lateralise temporal lobe epilepsy (TLE) by building a classification system that uses directed functional connectivity patterns estimated during EEG periods without visible pathological activity. Methods:Resting-state high-density EEG recording data from 20 left TLE patients, 20 right TLE pat...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.09.021

    authors： Verhoeven T,Coito A,Plomp G,Thomschewski A,Pittau F,Trinka E,Wiest R,Schaller K,Michel C,Seeck M,Dambre J,Vulliemoz S,van Mierlo P

    更新日期：2017-09-28 00:00:00

  • Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome.

    abstract：OBJECTIVE:To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS:Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101662

    authors： Blanco-Hinojo L,Pujol J,Esteba-Castillo S,Martínez-Vilavella G,Giménez-Palop O,Gabau E,Casamitjana L,Deus J,Novell R,Caixàs A

    更新日期：2019-01-01 00:00:00

  • Data fusion detects consistent relations between non-lesional white matter myelin, executive function, and clinical characteristics in multiple sclerosis.

    abstract：:We examined the influence of dysfunctional, non-lesional white matter on cognitive performance in multiple sclerosis (MS). Forty-six MS subjects were assessed using MRI-based myelin water imaging (MWI), and average myelin water fraction (MWF) values across 20 white matter regions of interest (ROIs) were determined. A ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101926

    authors： Baumeister TR,Lin SJ,Vavasour I,Kolind S,Kosaka B,Li DKB,Traboulsee A,MacKay A,McKeown MJ

    更新日期：2019-01-01 00:00:00

  • Disrupted modular organization of primary sensory brain areas in schizophrenia.

    abstract：:Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organizat...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.02.035

    authors： Bordier C,Nicolini C,Forcellini G,Bifone A

    更新日期：2018-03-01 00:00:00

  • Connectivity of precuneus to the default mode and dorsal attention networks: A possible invariant marker of long-term tinnitus.

    abstract：:Resting state functional connectivity studies of tinnitus have provided inconsistent evidence concerning its neural bases. This may be due to differences in the methodology used, but it is also likely related to the heterogeneity of the tinnitus population. In this study, our goal was to identify resting state functio...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.07.015

    authors： Schmidt SA,Carpenter-Thompson J,Husain FT

    更新日期：2017-07-22 00:00:00

  • Prion disease diagnosis using subject-specific imaging biomarkers within a multi-kernel Gaussian process.

    abstract：:Prion diseases are a group of rare neurodegenerative conditions characterised by a high rate of progression and highly heterogeneous phenotypes. Whilst the most common form of prion disease occurs sporadically (sporadic Creutzfeldt-Jakob disease, sCJD), other forms are caused by prion protein gene mutations, or exposu...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102051

    authors： Canas LS,Sudre CH,De Vita E,Nihat A,Mok TH,Slattery CF,Paterson RW,Foulkes AJM,Hyare H,Cardoso MJ,Thornton J,Schott JM,Barkhof F,Collinge J,Ourselin S,Mead S,Modat M

    更新日期：2019-01-01 00:00:00