Abstract：
:Several studies in cancer research have suggested that cognitive dysfunction following chemotherapy, referred to in lay terms as "chemobrain", is a serious problem. At present, the changes in integrative brain function that underlie such dysfunction remain poorly understood. Recent developments in neuroimaging suggest that patterns of functional connectivity can provide a broadly applicable neuromarker of cognitive performance and other psychometric measures. The current study used multivariate analysis methods to identify patterns of disruption in resting state functional connectivity of the brain due to chemotherapy and the degree to which the disruptions can be linked to behavioral measures of distress and cognitive performance. Sixty two women (22 healthy control, 18 patients treated with adjuvant chemotherapy, and 22 treated without chemotherapy) were evaluated with neurocognitive measures followed by self-report questionnaires and open eyes resting-state fMRI scanning at three time points: diagnosis (M0, pre-adjuvant treatment), 1 month (M1), and 7 months (M7) after treatment. The results indicated deficits in cognitive health of breast cancer patients immediately after chemotherapy that improved over time. This psychological trajectory was paralleled by a disruption and later recovery of resting-state functional connectivity, mostly in the parietal and frontal brain regions. Mediation analysis showed that the functional connectivity alteration pattern is a separable treatment symptom from the decreased cognitive health. Current study indicates that more targeted support for patients should be developed to ameliorate these multi-faceted side effects of chemotherapy treatment on neural functioning and cognitive health.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Kardan O,Reuter-Lorenz PA,Peltier S,Churchill NW,Misic B,Askren MK,Jung MS,Cimprich B,Berman MGdoi
10.1016/j.nicl.2019.101654subject
Has Abstractpub_date
2019-01-01 00:00:00pages
101654issn
2213-1582pii
S2213-1582(19)30004-Xjournal_volume
21pub_type
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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abstract：:Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings...
journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.01.008
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2015.04.016
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2014.06.005
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2017.04.004
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2017.05.009
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.10.006
更新日期：2013-10-14 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102284
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.004
更新日期：2014-08-07 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.05.010
更新日期：2016-05-19 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.12.003
更新日期：2016-12-07 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.02.035
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2018.04.014
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2019.102004
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2018.10.017
更新日期：2018-01-01 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2018.05.024
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abstract：BACKGROUND:Grey matter (GM) atrophy in Alzheimer's disease (AD) is most commonly modeled as a function of time. However, this approach does not take into account inter-individual differences in initial disease severity or changes due to aging. Here, we modeled GM atrophy within individuals across the AD clinical spectr...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101786
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:There is little known about cardiorespiratory fitness and its association with volumes of the thalamus, hippocampus, and basal ganglia in multiple sclerosis (MS). Such inquiry is important for identifying a possible behavioral approach (e.g., aerobic exercise training) that might change volumes of deep gray ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.02.017
更新日期：2015-02-26 00:00:00
abstract：:Understanding abnormal resting-state functional connectivity of distributed brain networks may aid in probing and targeting mechanisms involved in major depressive disorder (MDD). To date, few studies have used resting state functional magnetic resonance imaging (rs-fMRI) to attempt to discriminate individuals with MD...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.02.018
更新日期：2016-03-02 00:00:00
abstract：OBJECTIVE:To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission. BACKGROUND:CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medication use, including opioids. METHODS:We scanned 15 migraine patients d...
journal_title：NeuroImage. Clinical
pub_type： 临床试验,杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.01.001
更新日期：2018-01-06 00:00:00
abstract：Background:Behavioral, cognitive and functional particularities in autism differ according to autism subgroups and might be associated with domain-specific cognitive strengths. It is unknown whether structural changes support this specialization. We investigated the link between cortical folding, its maturation and cog...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.04.036
更新日期：2018-08-04 00:00:00
