Abstract:
:Understanding abnormal resting-state functional connectivity of distributed brain networks may aid in probing and targeting mechanisms involved in major depressive disorder (MDD). To date, few studies have used resting state functional magnetic resonance imaging (rs-fMRI) to attempt to discriminate individuals with MDD from individuals without MDD, and to our knowledge no investigations have examined a remitted (r) population. In this study, we examined the efficiency of support vector machine (SVM) classifier to successfully discriminate rMDD individuals from healthy controls (HCs) in a narrow early-adult age range. We empirically evaluated four feature selection methods including multivariate Least Absolute Shrinkage and Selection Operator (LASSO) and Elastic Net feature selection algorithms. Our results showed that SVM classification with Elastic Net feature selection achieved the highest classification accuracy of 76.1% (sensitivity of 81.5% and specificity of 68.9%) by leave-one-out cross-validation across subjects from a dataset consisting of 38 rMDD individuals and 29 healthy controls. The highest discriminating functional connections were between the left amygdala, left posterior cingulate cortex, bilateral dorso-lateral prefrontal cortex, and right ventral striatum. These appear to be key nodes in the etiopathophysiology of MDD, within and between default mode, salience and cognitive control networks. This technique demonstrates early promise for using rs-fMRI connectivity as a putative neurobiological marker capable of distinguishing between individuals with and without rMDD. These methods may be extended to periods of risk prior to illness onset, thereby allowing for earlier diagnosis, prevention, and intervention.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Bhaumik R,Jenkins LM,Gowins JR,Jacobs RH,Barba A,Bhaumik DK,Langenecker SAdoi
10.1016/j.nicl.2016.02.018subject
Has Abstractpub_date
2016-03-02 00:00:00pages
390-398issn
2213-1582pii
S2213-1582(16)30039-0journal_volume
16pub_type
杂志文章abstract::Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101705
更新日期:2019-01-01 00:00:00
abstract::The primary objective of this study was to evaluate changes in cerebral blood flow (CBF) using arterial spin labeling MRI between day 4 of life (DOL4) and day 11 of life (DOL11) in neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia. The secondary objectives were to compare CBF values between ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101939
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:This study aims to systematically evaluate the accuracy and precision of pool size ratio (PSR) measurements from quantitative magnetization transfer (qMT) acquisitions using simplified models in the context of assessing injury-associated spatiotemporal changes in spinal cords of non-human primates. This study a...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101921
更新日期:2019-01-01 00:00:00
abstract::The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events a...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.05.010
更新日期:2016-05-19 00:00:00
abstract::Borderline personality disorder (BPD) is characterized by pronounced emotional instability in interpersonal relations. Previous studies have shown increased activity in the amygdala, an imaging phenotype of negative affect. However, clinical accounts of BPD have drawn attention to deficits in social cognition and thei...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101737
更新日期:2019-01-01 00:00:00
abstract::Apraxia of speech is a motor speech disorder thought to result from impaired planning or programming of articulatory movements. It can be the initial or only manifestation of a degenerative disease, termed primary progressive apraxia of speech (PPAOS). The aim of this study was to use task-free functional magnetic res...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.02.036
更新日期:2018-03-03 00:00:00
abstract::Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children. Post-surgical outcome is improved by presurgical lesion detection on structural MRI. Automated computational techniques have improved detection of focal corti...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.12.030
更新日期:2016-12-30 00:00:00
abstract:BACKGROUND:Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent a possible source of impaired neurocognitive functioning and were analyzed in these patients. METHODS:Eig...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102287
更新日期:2020-01-01 00:00:00
abstract::Cognitive reasoning is thought to require functional interactions between whole-brain networks. Such networks rely on both cerebral hemispheres, with the corpus callosum providing cross-hemispheric communication. Here we used high-field functional magnetic resonance imaging (7 T fMRI), a well validated cognitive task,...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.11.005
更新日期:2019-01-01 00:00:00
abstract::Patients with schizophrenia show response inhibition deficits equal to or greater than those seen in impulse-control disorders, and these deficits contribute to poor outcome. However, little is known about the circuit abnormalities underlying this impairment. To address this, we examined stop signal task performance i...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.01.001
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Findings from neurodevelopmental studies indicate that adolescents with psychosis spectrum disorders have delayed neurocognitive performance relative to the maturational state of their healthy peers. Using machine learning, we generated a model of neurocognitive age in healthy adults and investigated whether...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.101624
更新日期:2019-01-01 00:00:00
abstract::Stroke is one of the most important causes of acquired epilepsy in the adult population. While factors such as cortical involvement and haemorrhage have been associated with increased seizure risk, the mechanisms underlying the development of epilepsy after stroke remain unclear. One hypothesised mechanism is an excit...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章,评审
doi:10.1016/j.nicl.2019.102069
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Hippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionatel...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.11.017
更新日期:2016-11-17 00:00:00
abstract::In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.04.009
更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression, yet its mechanism of action is still unclear. Understanding the mechanism of action of ECT can advance the optimization of magnetic seizure therapy (MST) towards higher efficacy and less cognitive impairment. Given the ne...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.10.015
更新日期:2018-01-01 00:00:00
abstract::Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102500
更新日期:2020-01-01 00:00:00
abstract::Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.02.003
更新日期:2015-02-16 00:00:00
abstract:INTRODUCTION:Differentiation between self-produced tactile stimuli and touch by others is necessary for social interactions and for a coherent concept of "self". In attention-deficit-hyperactivity-disorder (ADHD), tactile hypersensitivity and social cognition problems are part of the symptomatology, but pathophysiologi...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102317
更新日期:2020-01-01 00:00:00
abstract::Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic systemic and cerebral vascular disease that leads to early and cumulative neurological damage. Few studies have quantified the effects of this disease on brain morphometry and even fewer efforts have been devoted to older p...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.04.023
更新日期:2017-04-29 00:00:00
abstract::Chromosome 22q11.2 deletion syndrome (22q11DS) is a genetic disease known to lead to cerebral structural alterations, which we study using the framework of the macroscopic white-matter connectome. We create weighted connectomes of 44 patients with 22q11DS and 44 healthy controls using diffusion tensor magnetic resonan...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.11.017
更新日期:2015-11-26 00:00:00
abstract::Despite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom predic...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.10.017
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema pose a challenge to conventional tractography using the standard diffusion tensor model. The aim of t...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.03.009
更新日期:2015-03-20 00:00:00
abstract:Background:Radiological biomarkers which correlate with visual function are needed to improve the clinical management of optic pathway glioma (OPG) patients. Currently, these are not available using conventional magnetic resonance imaging (MRI) sequences. The aim of this study was to determine whether diffusion MRI cou...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.10.010
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND:Aerobic exercise training (AET) has been shown to provide general health benefits, and to improve motor behaviours in particular, in individuals with Parkinson's disease (PD). However, the influence of AET on their motor learning capacities, as well as the change in neural substrates mediating this effect re...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.09.011
更新日期:2016-09-14 00:00:00
abstract::Damage to the white matter underlying the left posterior temporal lobe leads to deficits in multiple language functions. The posterior temporal white matter may correspond to a bottleneck where both dorsal and ventral language pathways are vulnerable to simultaneous damage. Damage to a second putative white matter bot...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.02.019
更新日期:2017-02-24 00:00:00
abstract::[This corrects the article DOI: 10.1016/j.nicl.2012.10.003.]. ...
journal_title:NeuroImage. Clinical
pub_type: 已发布勘误
doi:10.1016/j.nicl.2013.04.013
更新日期:2013-05-02 00:00:00
abstract:OBJECTIVE:In DSM-5, pain-related fear during anticipation of vaginal penetration is a diagnostic criterion of Genito-Pelvic Pain/Penetration Disorder (GPPPD). We aimed to investigate subjective and brain responses during anticipatory fear and subsequent induction of vestibular pain in women with GPPPD. METHODS:Women w...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.07.017
更新日期:2017-07-25 00:00:00
abstract::Perceptional abnormalities in schizophrenia are associated with hallucinations and delusions, but also with negative symptoms and poor functional outcome. Perception can be studied using EEG-derived event related potentials (ERPs). Because of their excellent temporal resolution, ERPs have been used to ask when percept...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.08.009
更新日期:2016-08-10 00:00:00
abstract::The accurate identification of glioblastoma progression remains an unmet clinical need. The aim of this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy (MRS) and the values of the apparent diffusion coefficient (ADC) to e...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.02.016
更新日期:2016-02-26 00:00:00
abstract::Presurgical evaluation that can precisely delineate the epileptogenic zone (EZ) is one important step for successful surgical resection treatment of refractory epilepsy patients. The noninvasive EEG-fMRI recording technique combined with general linear model (GLM) analysis is considered an important tool for estimatin...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.12.005
更新日期:2017-12-05 00:00:00