当前位置： SCI文献检索 > NeuroImage-Clinical期刊下所有文献 > Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.

Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.

Abstract：

:Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children. Post-surgical outcome is improved by presurgical lesion detection on structural MRI. Automated computational techniques have improved detection of focal cortical dysplasias in adults but have not yet been effective when applied to developing brains. There is therefore a need to develop reliable and sensitive methods to address the particular challenges of a paediatric cohort. We developed a classifier using surface-based features to identify focal abnormalities of cortical development in a paediatric cohort. In addition to established measures, such as cortical thickness, grey-white matter blurring, FLAIR signal intensity, sulcal depth and curvature, our novel features included complementary metrics of surface morphology such as local cortical deformation as well as post-processing methods such as the "doughnut" method - which quantifies local variability in cortical morphometry/MRI signal intensity, and per-vertex interhemispheric asymmetry. A neural network classifier was trained using data from 22 patients with focal epilepsy (mean age = 12.1 ± 3.9, 9 females), after intra- and inter-subject normalisation using a population of 28 healthy controls (mean age = 14.6 ± 3.1, 11 females). Leave-one-out cross-validation was used to quantify classifier sensitivity using established features and the combination of established and novel features. Focal cortical dysplasias in our paediatric cohort were correctly identified with a higher sensitivity (73%) when novel features, based on our approach for detecting local cortical changes, were included, when compared to the sensitivity using only established features (59%). These methods may be applicable to aiding identification of subtle lesions in medication-resistant paediatric epilepsy as well as to the structural analysis of both healthy and abnormal cortical development.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Adler S,Wagstyl K,Gunny R,Ronan L,Carmichael D,Cross JH,Fletcher PC,Baldeweg T

doi

10.1016/j.nicl.2016.12.030

subject

Has Abstract

pub_date

2016-12-30 00:00:00

pages

18-27

issn

2213-1582

pii

S2213-1582(16)30267-4

journal_volume

pub_type

杂志文章

在线工具

Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy.