Abstract：
:Limb weakness in amyotrophic lateral sclerosis (ALS) is typically asymmetric. Previous studies have identified an effect of limb dominance on onset and spread of weakness, however relative atrophy of dominant and non-dominant brain regions has not been investigated. Our objective was to use voxel-based morphometry (VBM) to explore gray matter (GM) asymmetry in ALS, in the context of limb dominance. 30 ALS subjects were matched with 17 healthy controls. All subjects were right-handed. Each underwent a structural MRI sequence, from which GM segmentations were generated. Patterns of GM atrophy were assessed in ALS subjects with first weakness in a right-sided limb (n = 15) or left-sided limb (n = 15). Within each group, a voxelwise comparison was also performed between native and mirror GM images, to identify regions of hemispheric GM asymmetry. Subjects with ALS showed disproportionate atrophy of the dominant (left) motor cortex hand area, irrespective of the side of first limb weakness (p < 0.01). Asymmetric atrophy of the left somatosensory cortex and temporal gyri was only observed in ALS subjects with right-sided onset of limb weakness. Our VBM protocol, contrasting native and mirror images, was able to more sensitively detect asymmetric GM pathology in a small cohort, compared with standard methods. These findings indicate particular vulnerability of dominant upper limb representation in ALS, supporting previous clinical studies, and with implications for cortical organisation and selective vulnerability.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Devine MS,Pannek K,Coulthard A,McCombe PA,Rose SE,Henderson RDdoi
10.1016/j.nicl.2015.03.006subject
Has Abstractpub_date
2015-03-14 00:00:00pages
782-7issn
2213-1582pii
S2213-1582(15)00048-0journal_volume
7pub_type
杂志文章abstract：:In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.04.009
更新日期：2018-04-06 00:00:00
abstract：OBJECTIVE:To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS:Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101662
更新日期：2019-01-01 00:00:00
abstract：:In the military, explosive blasts are a significant cause of mild traumatic brain injuries (mTBIs). The symptoms associated with blast mTBIs causes significant economic burdens and a diminished quality of life for many service members. At present, the distinction of the injury mechanism (blast versus non-blast) may no...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101793
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Cognitive impairment is a common consequence of stroke, and the rewiring of the surviving brain circuits might contribute to cognitive recovery. Studies investigating how the functional connectivity of networks change across time and whether their remapping relates to cognitive recovery in stroke...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102538
更新日期：2020-12-17 00:00:00
abstract：:Perceptional abnormalities in schizophrenia are associated with hallucinations and delusions, but also with negative symptoms and poor functional outcome. Perception can be studied using EEG-derived event related potentials (ERPs). Because of their excellent temporal resolution, ERPs have been used to ask when percept...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.08.009
更新日期：2016-08-10 00:00:00
abstract：:Neuropsychological assessment, brain imaging and computational modelling have augmented our understanding of the multifaceted functional deficits in people with language disorders after stroke. Despite the volume of research using each technique, no studies have attempted to assimilate all three approaches in order to...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.03.031
更新日期：2018-03-27 00:00:00
abstract：:Autism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detectio...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102181
更新日期：2020-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102500
更新日期：2020-01-01 00:00:00
abstract：:Psychomotor retardation and reduced daily activities are core features of the depressive syndrome including bipolar disorder (BD). It was the aim of this study to investigate white matter microstructure of the motor system in BD during depression and its association with motor activity. We hypothesized reduced physica...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.09.033
更新日期：2018-01-01 00:00:00
abstract：:Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morphology or function....
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.06.009
更新日期：2017-06-09 00:00:00
abstract：:Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed in patients with schizophrenia and has been hypothesized to result from a deficit in the control of attention. Here, an attentional task and functional brain imaging were used to probe the neural correlates of increase...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101853
更新日期：2019-01-01 00:00:00
abstract：Background:Previous publications indicate that Alzheimer's Disease (AD) related cortical atrophy may develop in asymmetric patterns, with accentuation of the left hemisphere. Since fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the regional cerebral metabolic rate of glucose (rCMRgl) provide ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.07.016
更新日期：2018-07-17 00:00:00
abstract：:Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.02.003
更新日期：2015-02-16 00:00:00
abstract：:Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic systemic and cerebral vascular disease that leads to early and cumulative neurological damage. Few studies have quantified the effects of this disease on brain morphometry and even fewer efforts have been devoted to older p...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.04.023
更新日期：2017-04-29 00:00:00
abstract：:Patients with congenital heart disease (CHD) are at risk for neurocognitive impairments. Little is known about the impact of CHD on the organization of large-scale brain networks. We applied graph analysis techniques to diffusion tensor imaging (DTI) data obtained from 49 adolescents with dextro-transposition of the g...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.nicl.2015.01.013
更新日期：2015-01-27 00:00:00
abstract：:Verbal information is better retained when it is self-generated rather than when it is received passively. The application of self-generation procedures has been found to improve memory in healthy elderly and in individuals with impaired cognition. Overall, the available studies support the notion that active particip...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.02.006
更新日期：2015-02-20 00:00:00
abstract：:The electroencephalogram (EEG) constitutes a relevant tool to study neural dynamics and to develop brain-machine interfaces (BMI) for rehabilitation of patients with paralysis due to stroke. However, the EEG is easily contaminated by artifacts of physiological origin, which can pollute the measured cortical activity a...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.09.035
更新日期：2018-01-01 00:00:00
abstract：:Atypical visual perception in people with autism spectrum disorders (ASD) is hypothesized to stem from an imbalance in excitatory and inhibitory processes in the brain. We used neuronal oscillations in the gamma frequency range (30-90 Hz), which emerge from a balanced interaction of excitation and inhibition in the br...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.06.015
更新日期：2013-07-02 00:00:00
abstract：:Recent evidence suggests that immobilization of the upper limb for 2-3 weeks induces changes in cortical thickness as well as motor performance. In constraint induced (CI) therapy, one of the most effective interventions for hemiplegia, the non-paretic arm is constrained to enforce the use of the paretic arm in the ho...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.05.005
更新日期：2013-05-21 00:00:00
abstract：:Noninvasive markers of brain function could yield biomarkers in many neurological disorders. Disease models constrained by coordinate-based meta-analysis are likely to increase this yield. Here, we evaluate a thalamic model of temporal lobe epilepsy that we proposed in a coordinate-based meta-analysis and extended in ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.002
更新日期：2014-08-07 00:00:00
abstract：:Simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) is an emerging neuromodulation approach, that enables simultaneous volitional regulation of both hemodynamic (BOLD fMRI) and electrophysiological (EEG) brain activities. Here we report the first application of rtfMRI-EEG-nf for emotion self-regulation t...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102331
更新日期：2020-01-01 00:00:00
abstract：:Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of cognitive impairment and dementia. There is increasing awareness that SVD exerts its clinical effects by disrupting white matter connections, predominantly disrupting connections between rich club nodes, a s...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102048
更新日期：2019-01-01 00:00:00
abstract：:Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals wi...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102273
更新日期：2020-01-01 00:00:00
abstract：:Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast (BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on cerebrovascular reactivity (CVR), resting blood flow (CBF), oxygen extraction fraction (OEF), and resting oxidative metabolism (CMRO2). Vascul...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.05.009
更新日期：2017-05-16 00:00:00
abstract：AIM:Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domest...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101973
更新日期：2019-01-01 00:00:00
abstract：:The symptoms witnessed in unexplained death in epilepsy (SUDEP) suggest a breakdown of central autonomic control. Since the brainstem plays a crucial role in autonomic control, the objectives of this study were 1. To investigate if temporal lobe epilepsy (TLE) is associated with brainstem atrophy and to characterize i...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.06.010
更新日期：2014-07-09 00:00:00
abstract：BACKGROUND:The anatomy of the substantia nigra on conventional MRI is controversial. Even using histological techniques it is difficult to delineate with certainty from surrounding structures. We sought to define the anatomy of the SN using high field spin-echo MRI of pathological material in which we could study the a...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.11.015
更新日期：2016-11-17 00:00:00
abstract：:We hypothesized that expert epileptologists can detect seizures directly by visually analyzing EEG plot images, unlike automated methods that analyze spectro-temporal features or complex, non-stationary features of EEG signals. If so, seizure detection could benefit from convolutional neural networks because their vis...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101684
更新日期：2019-01-01 00:00:00
abstract：:Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Gen...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102540
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:There is little known about cardiorespiratory fitness and its association with volumes of the thalamus, hippocampus, and basal ganglia in multiple sclerosis (MS). Such inquiry is important for identifying a possible behavioral approach (e.g., aerobic exercise training) that might change volumes of deep gray ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.02.017
更新日期：2015-02-26 00:00:00
