Abstract：
:The symptoms witnessed in unexplained death in epilepsy (SUDEP) suggest a breakdown of central autonomic control. Since the brainstem plays a crucial role in autonomic control, the objectives of this study were 1. To investigate if temporal lobe epilepsy (TLE) is associated with brainstem atrophy and to characterize it using graph Analysis 2. To compare the findings with those in two probable TLESUDEP. T1 images were obtained from 17 controls, 30 TLE (16 with mesial-temporal-sclerosis (TLE-MTS) and 14 without (TLE-no)) and from 2 patients who died of SUDEP. The brainstem was extracted, warped onto a brainstem atlas and Jacobian determinants maps (JDM) calculated. SPM8 was used to compare the JDMs at the group level, z-score maps were calculated for single subject analysis. Brainstem regions encompassing autonomic structures were identified based on macroscopic landmarks and mean z-scores from 5 × 5 × 5 voxel cubes extracted to calculate a new measure called atrophy-similarity index (ASI) for graph analysis. TLE-MTS had volume loss in the dorsal mesencephalon. The SUDEP cases had severe and more extensive volume loss in the same region. Nodal degrees and participation coefficients were decreased and local efficiency increased in SUDEP compared to controls. TLE is associated with volume loss in brainstem regions involved in autonomic control. Structural damage in these regions might increase the risk for a fatal dysregulation during situations with increased demand such as following severe seizures.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Mueller SG,Bateman LM,Laxer KDdoi
10.1016/j.nicl.2014.06.010subject
Has Abstractpub_date
2014-07-09 00:00:00pages
208-16issn
2213-1582pii
S2213-1582(14)00086-2journal_volume
5pub_type
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.01.010
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2012.09.012
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.03.011
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journal_title：NeuroImage. Clinical
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更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
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更新日期：2017-07-25 00:00:00
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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