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Identifying motor functional neurological disorder using resting-state functional connectivity.

Abstract：

BACKGROUND:Motor functional neurological disorder (mFND) is a clinical diagnosis with reliable features; however, patients are reluctant to accept the diagnosis and physicians themselves bear doubts on potential misdiagnoses. The identification of a positive biomarker could help limiting unnecessary costs of multiple referrals and investigations, thus promoting early diagnosis and allowing early engagement in appropriate therapy. OBJECTIVES:To test whether resting-state (RS) functional magnetic resonance imaging could discriminate patients suffering from mFND from healthy controls. METHODS:We classified 23 mFND patients and 25 age- and gender-matched healthy controls based on whole-brain RS functional connectivity (FC) data, using a support vector machine classifier and the standard Automated Anatomic Labeling (AAL) atlas, as well as two additional atlases for validation. RESULTS:Accuracy, specificity and sensitivity were over 68% (p = 0.004) to discriminate between mFND patients and controls, with consistent findings between the three tested atlases. The most discriminative connections comprised the right caudate, amygdala, prefrontal and sensorimotor regions. Post-hoc seed connectivity analyses showed that these regions were hyperconnected in patients compared to controls. CONCLUSIONS:The good accuracy to discriminate patients from controls suggests that RS FC could be used as a biomarker with high diagnostic value in future clinical practice to identify mFND patients at the individual level.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Wegrzyk J,Kebets V,Richiardi J,Galli S,de Ville DV,Aybek S

doi

10.1016/j.nicl.2017.10.012

subject

Has Abstract

pub_date

2017-10-12 00:00:00

pages

163-168

issn

2213-1582

pii

S2213-1582(17)30253-X

journal_volume

17

pub_type

杂志文章

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