Abstract:
:Frontotemporal dementia (FTD) is difficult to diagnose, due to its heterogeneous nature and overlap in symptoms with primary psychiatric disorders. Brain MRI for atrophy is a key biomarker but lacks sensitivity in the early stage. Morphometric MRI-based measures and machine learning techniques are a promising tool to improve diagnostic accuracy. Our aim was to review the current state of the literature using morphometric MRI to classify FTD and assess its applicability for clinical practice. A search was completed using Pubmed and PsychInfo of studies which conducted a classification of subjects with FTD from non-FTD (controls or another disorder) using morphometric MRI metrics on an individual level, using single or combined approaches. 28 relevant articles were included and systematically reviewed following PRISMA guidelines. The studies were categorized based on the type of FTD subjects included and the group(s) against which they were classified. Studies varied considerably in subject selection, MRI methodology, and classification approach, and results are highly heterogeneous. Overall many studies indicate good diagnostic accuracy, with higher performance when differentiating FTD from controls (highest result was accuracy of 100%) than other dementias (highest result was AUC of 0.874). Very few machine learning algorithms have been tested in prospective replication. In conclusion, morphometric MRI with machine learning shows potential as an early diagnostic biomarker of FTD, however studies which use rigorous methodology and validate findings in an independent real-life cohort are necessary before this method can be recommended for use clinically.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
McCarthy J,Collins DL,Ducharme Sdoi
10.1016/j.nicl.2018.08.028subject
Has Abstractpub_date
2018-01-01 00:00:00pages
685-696issn
2213-1582pii
S2213-1582(18)30269-9journal_volume
20pub_type
杂志文章abstract::Anticipation of potentially threatening social situations is a key process in social anxiety disorder (SAD). In other anxiety disorders, recent research of neural correlates of anticipation of temporally unpredictable threat suggests a temporally dissociable involvement of amygdala and bed nucleus of the stria termina...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101735
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins. MATERIALS AND METHODS:We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n =...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.101648
更新日期:2019-01-01 00:00:00
abstract::Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This stu...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.05.011
更新日期:2015-05-28 00:00:00
abstract:Objective:Generalized tonic-clonic seizures are accompanied by cardiovascular and respiratory sequelae that threaten survival. The frequency of these seizures is a major risk factor for sudden unexpected death in epilepsy (SUDEP), a leading cause of untimely death in epilepsy. The circumstances accompanying such fatal ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.07.015
更新日期:2018-07-18 00:00:00
abstract::In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.04.009
更新日期:2018-04-06 00:00:00
abstract::Muscle sympathetic nerve activity (MSNA) is greatly elevated in patients with obstructive sleep apnoea (OSA) during daytime wakefulness, leading to hypertension, but the underlying mechanisms are poorly understood. By recording MSNA concurrently with functional Magnetic Resonance Imaging (fMRI) of the brain we aimed t...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.08.021
更新日期:2014-08-27 00:00:00
abstract::Autism spectrum disorder is associated with an altered early brain development. However, the specific cortical structure abnormalities underlying this disorder remain largely unknown. Nonetheless, atypical cortical folding provides lingering evidence of early disruptions in neurodevelopmental processes and identifying...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.03.008
更新日期:2014-03-25 00:00:00
abstract::While gray matter (GM) anomalies have been reported for attention-deficit/hyperactivity disorder (ADHD), investigating their associations with cognitive deficits and individual symptom domains can help pinpoint the neural underpinnings critical for the pathology of ADHD, particularly the persist form of ADHD. In this ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.04.035
更新日期:2018-05-02 00:00:00
abstract::This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.102100
更新日期:2020-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1016/j.nicl.2012.10.003.]. ...
journal_title:NeuroImage. Clinical
pub_type: 已发布勘误
doi:10.1016/j.nicl.2013.04.013
更新日期:2013-05-02 00:00:00
abstract:BACKGROUND:The functional significance of the impairment shown by patients with ADHD on response inhibition tasks is unclear. Dysfunctional behavioral and BOLD responses to rare no-go cues might reflect disruption of response inhibition (mediating withholding the response) or selective attention (identifying the rare c...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101677
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Diffusion imaging tractography is increasingly used to trace critical fiber tracts in brain tumor patients to reduce the risk of post-operative neurological deficit. However, the effects of peritumoral edema pose a challenge to conventional tractography using the standard diffusion tensor model. The aim of t...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.03.009
更新日期:2015-03-20 00:00:00
abstract::Despite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom predic...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.10.017
更新日期:2018-01-01 00:00:00
abstract::The perception of faces and consequent social inferences are fundamental for interpersonal communication. While facial expression is important for interindividual communication, constitutional and acquired features are crucial for basic emotions of attraction or repulsion. An emotional bias in face processing has been...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102269
更新日期:2020-01-01 00:00:00
abstract::Chromosome 22q11.2 deletion syndrome (22q11DS) is a genetic disease known to lead to cerebral structural alterations, which we study using the framework of the macroscopic white-matter connectome. We create weighted connectomes of 44 patients with 22q11DS and 44 healthy controls using diffusion tensor magnetic resonan...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.11.017
更新日期:2015-11-26 00:00:00
abstract:AIMS/HYPOTHESES:It is now generally accepted that diabetes increases the risk for cognitive impairment, but the precise mechanisms are poorly understood. In recent years, resting-state functional magnetic resonance imaging (rs-fMRI) is increasingly used to investigate the neural basis of cognitive dysfunction in type 2...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.101629
更新日期:2019-01-01 00:00:00
abstract:Background:Advanced neuroimaging and computational methods offer opportunities for more accurate prognosis. We hypothesized that near-term regional white matter (WM) microstructure, assessed on diffusion tensor imaging (DTI), using exhaustive feature selection with cross-validation would predict neurodevelopment in pre...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.11.023
更新日期:2017-11-29 00:00:00
abstract:PURPOSE:This prospective clinical trial investigated sodium (23Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. METHODS:28 glioma patients underwent 23Na MRI on a 7T sc...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102427
更新日期:2020-01-01 00:00:00
abstract::Network functioning during cognitive tasks is of major interest in Alzheimer's disease (AD). Cognitive functioning in AD includes variable performance in short-term memory (STM). In most studies, the verbal STM functioning in AD patients has been interpreted within the phonological loop subsystem of Baddeley's working...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101892
更新日期:2019-01-01 00:00:00
abstract::The ability to empathise relies in part on using one's own affective experience to simulate the affective experience of others. This process is supported by a number of brain areas including the anterior insula (AI), anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), and the amygdala. Children with cond...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.01.027
更新日期:2018-02-28 00:00:00
abstract::Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed in patients with schizophrenia and has been hypothesized to result from a deficit in the control of attention. Here, an attentional task and functional brain imaging were used to probe the neural correlates of increase...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101853
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD t...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.01.017
更新日期:2017-01-17 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is a disabling disorder associated with resting state functional connectivity alterations. However, whether specific brain regions are altered in PTSD or whether the whole brain network organization differs remains unclear. PTSD can be treated with trauma-focused therapy, although ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.12.008
更新日期:2015-12-18 00:00:00
abstract:Background:Most children who are exposed to threat-related adversity (e.g., violence, abuse, neglect) are resilient - that is, they show stable trajectories of healthy psychological development. Despite this, most research on neurodevelopmental changes following adversity has focused on the neural correlates of negativ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.06.026
更新日期:2018-06-27 00:00:00
abstract::Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.10.017
更新日期:2015-10-31 00:00:00
abstract::Mood disorders and behavioral are broad psychiatric diagnostic categories that have different symptoms and neurobiological mechanisms, but share some neurocognitive similarities, one of which is an elevated risk for reading deficit. Our aim was to determine the influence of mood versus behavioral dysregulation on read...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.06.020
更新日期:2017-06-23 00:00:00
abstract::Several studies in cancer research have suggested that cognitive dysfunction following chemotherapy, referred to in lay terms as "chemobrain", is a serious problem. At present, the changes in integrative brain function that underlie such dysfunction remain poorly understood. Recent developments in neuroimaging suggest...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101654
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) may alleviate motor symptoms in Parkinson's disease (PD). However, the neurophysiological effects of tDCS on cortical activation, synchronization, and the relation to clinical motor symptoms and motor integration need characterization. OBJECTIVE:We aimed to exp...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.nicl.2019.101689
更新日期:2019-01-01 00:00:00
abstract::Sporadic cerebral amyloid angiopathy (CAA) is a very common small vessel disease of the brain, showing preferential and progressive amyloid-βdeposition in the wall of small arterioles and capillaries of the leptomeninges and cerebral cortex. CAA now encompasses not only a specific cerebrovascular pathological trait, b...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章,评审
doi:10.1016/j.nicl.2017.05.002
更新日期:2017-05-05 00:00:00
abstract::Gulf War Illness (GWI) is a chronic, multi-symptom illness that affects approximately 25% of Gulf veterans, with cognitive fatigue as one of its primary symptoms. Here, we investigated the neural networks associated with cognitive fatigue in GWI by asking 35 veterans with GWI and 25 healthy control subjects to perform...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.101641
更新日期:2019-01-01 00:00:00