Abstract：
:Gulf War Illness (GWI) is a chronic, multi-symptom illness that affects approximately 25% of Gulf veterans, with cognitive fatigue as one of its primary symptoms. Here, we investigated the neural networks associated with cognitive fatigue in GWI by asking 35 veterans with GWI and 25 healthy control subjects to perform a series of fatiguing tasks while in the MRI scanner. Two types of cognitive fatigue were assessed: state fatigue, which is the fatigue that developed as the tasks were completed, and trait fatigue, or one's propensity to experience fatigue when assessed over several weeks. Our results showed that the neural networks associated with state and trait fatigue differed. Irrespective of group, the network underlying trait fatigue included areas associated with memory whereas the neural network associated with state fatigue included key areas of a fronto-striatal-thalamic circuit that has been implicated in fatigue in other populations. As in other investigations of fatigue, the caudate of the basal ganglia was implicated in fatigue. Furthermore, individuals with GWI showed greater activation than the HC group in frontal and parietal areas for the less difficult task. This suggests that an inability to modulate brain activation as task demands change may underlie fatigue in GWI.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Wylie GR,Genova H,Dobryakova E,DeLuca J,Chiaravalloti N,Falvo M,Cook Ddoi
10.1016/j.nicl.2018.101641subject
Has Abstractpub_date
2019-01-01 00:00:00pages
101641issn
2213-1582pii
S2213-1582(18)30389-9journal_volume
21pub_type
杂志文章abstract：OBJECTIVE:To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS:Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimodal analyses of MRI inc...
journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2017.01.024
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2016.11.015
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
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abstract：:SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic Paraplegia. The disease has a wide phenotypic variability indicating many regions of the nervous system besides the corticospinal tract are affected. Despite this, anatomical and phenotypic characterization is restricted. In the present stud...
journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.06.009
更新日期：2014-08-15 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.08.021
更新日期：2014-08-27 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.10.015
更新日期：2018-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102008
更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章,meta分析
doi：10.1016/j.nicl.2019.101809
更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102362
更新日期：2020-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101892
更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101926
更新日期：2019-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.08.028
更新日期：2018-01-01 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.05.011
更新日期：2015-05-28 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2013.03.004
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.07.008
更新日期：2017-07-12 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2015.03.019
更新日期：2015-04-08 00:00:00
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journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.04.036
更新日期：2018-08-04 00:00:00
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journal_title：NeuroImage. Clinical
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doi：10.1016/j.nicl.2014.05.002
更新日期：2014-05-10 00:00:00
abstract：:Cerebral Microbleeds (CMBs) are small chronic brain hemorrhages, which have been considered as diagnostic indicators for different cerebrovascular diseases including stroke, dysfunction, dementia, and cognitive impairment. However, automated detection and identification of CMBs in Magnetic Resonance (MR) images is a v...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102464
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Grey matter (GM) atrophy in Alzheimer's disease (AD) is most commonly modeled as a function of time. However, this approach does not take into account inter-individual differences in initial disease severity or changes due to aging. Here, we modeled GM atrophy within individuals across the AD clinical spectr...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101786
更新日期：2019-01-01 00:00:00
abstract：:Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Gen...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102540
更新日期：2020-12-29 00:00:00
abstract：INTRODUCTION:In vivo clinical, anatomical and metabolic differences between posterior cortical atrophy (PCA) patients presenting with different Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers profiles are still unknown. METHODS:Twenty-seven PCA patients underwent CSF examination and were classified as 1)...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.10.010
更新日期：2018-01-01 00:00:00
abstract：:It is difficult to distinguish schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar disorder with psychosis (BPP) as their clinical diagnoses rely on symptoms that overlap. In this paper, we investigate if there is biological evidence to support the symptom-based clinical categories by looking across the th...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102284
更新日期：2020-01-01 00:00:00
