Abstract:
PURPOSE:This prospective clinical trial investigated sodium (23Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. METHODS:28 glioma patients underwent 23Na MRI on a 7T scanner (Siemens Healthcare, Erlangen, Germany) parallel to standard 3T MRI before chemoradiation. Areas of Gadolinium-contrast enhancement (gdce), non-enhancing T2-hyperintensity (regarded as edema), necrosis, and normal-appearing white matter (nawm) were segmented on 3T MRI imaging and were co-registered with the 23Na images. The median total 23Na concentrations of all areas were compared by pairwise t-tests. Furthermore, areas of gdce and edema were merged to yield the whole tumor area without necrosis. Subsequently, the difference in median of the 23Na concentration of this whole tumor area was compared between IDH-mutated and IDH wild-type gliomas as well as MGMT methylated and MGMT not-methylated glioblastomas using Whitney-Mann U-tests. All p-values were corrected after the Bonferroni-Holm procedure. RESULTS:The 23Na concentration increased successively from nawm to necrotic areas (mean ± sd: nawm = 37.84 ± 5.87 mM, edema = 54.69 ± 10.64 mM, gdce = 61.72 ± 12.95 mM, necrosis = 81.88 ± 17.53 mM) and the concentrations differed statistically significantly between all regarded areas (adjusted p-values for all pairwise comparisons < 0.05). Furthermore, IDH-mutated gliomas showed significantly higher 23Na concentrations than IDH wild-type gliomas (median [interquartile range]: IDH wild-type = 52.37 mM [45.98 - 58.56 mM], IDH mutated = 65.02 mM [58.87-67.05 mM], p = 0.039). Among the glioblastomas, there was a trend towards increased 23Na concentration in MGMT methylated tumors that did not reach statistical significance (median [interquartile range]: MGMT methylated = 57.59 mM [50.70 - 59.17 mM], MGMT not methylated = 48.78 mM [45.88 - 53.91 mM], p = 1.0). CONCLUSIONS:23Na MRI correlates with the IDH mutation status and could therefore enhance image guidance towards biopsy sites as wells as image-guided surgery and radiotherapy. Furthermore, the successive decrease of 23Na concentration from central necrosis to normal-appearing white matter suggests a correlation with tumor infiltration.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Regnery S,Behl NGR,Platt T,Weinfurtner N,Windisch P,Deike-Hofmann K,Sahm F,Bendszus M,Debus J,Ladd ME,Schlemmer HP,Rieken S,Adeberg S,Paech Ddoi
10.1016/j.nicl.2020.102427subject
Has Abstractpub_date
2020-01-01 00:00:00pages
102427issn
2213-1582pii
S2213-1582(20)30264-3journal_volume
28pub_type
杂志文章abstract::Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This stu...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.05.011
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abstract:OBJECTIVE:Hippocampal atrophy has been associated with mild cognitive impairment (MCI) in Parkinson's disease (PD). However, literature on how hippocampal atrophy affects the pathophysiology of cognitive impairment in PD has been limited. Previous studies assessed the hippocampus as an entire entity instead of their in...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2016.12.008
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2015.05.006
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.04.004
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abstract::Children who have been diagnosed with autism spectrum disorder (ASD) often show a marked deficit in measures of social cognition. In autistic adults, measures of social cognition have been shown to relate to differences in brain synchronization (as measured by fMRI) when individuals are processing naturalistic stimuli...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2020.102477
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abstract::Methamphetamine use disorder is associated with a high likelihood of relapse. Identifying robust predictors of relapse that have explanatory power is critical to develop secondary prevention based on a mechanistic understanding of relapse. Computational approaches have the potential to identify such predictive markers...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2019.101794
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abstract::Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging da...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2017.02.003
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abstract::Multiple genes have been implicated in Parkinson disease pathogenesis, but the relationship between regional expression of these genes and regional dysfunction across the brain is unknown. We address this question by joint analysis of high resolution magnetic resonance imaging data from the Parkinson's Progression Mar...
journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2018.01.009
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.05.024
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abstract::Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twe...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.01.020
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.12.018
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abstract::Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system. In this work, we evaluated the structural connectome of patients with PD, as mapped by diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deco...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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abstract:BACKGROUND:Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent a possible source of impaired neurocognitive functioning and were analyzed in these patients. METHODS:Eig...
journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2015.10.007
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2017.09.021
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doi:10.1016/j.nicl.2020.102331
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2020.102334
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abstract::Although brain plasticity in the form of gray matter increases and decreases has been observed in chronic pain, factors determining the patterns of directionality are largely unknown. Here we tested the hypothesis that fibromyalgia interacts with age to produce distinct patterns of gray matter differences, specificall...
journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2020.102301
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journal_title:NeuroImage. Clinical
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