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Relation of 18-F-Dopa PET with hypokinesia-rigidity, tremor and freezing in Parkinson's disease.

Abstract：

INTRODUCTION:In this retrospective study concerning patients with Parkinson's disease (PD) scanned with 18-F-Dopa PET (N = 129), we looked for an association between reduced 18-F-Dopa uptake and the key PD symptoms tremor and hypokinesia-rigidity. We hypothesized to find a stronger correlation between dopaminergic depletion in the striatum and hypokinesia-rigidity compared to tremor. METHODS:The onset side of symptoms (documented for 102 patients) as well as the first registered UPDRS (available for 79 patients) was used to correlate with F-Dopa uptake values in the caudate nucleus and putamen in this large retrospective sample. RESULTS:Reduced F-Dopa uptake was contralateral to hypokinesia-rigidity symptoms and correlated with its severity (quantified by UPDRS). For tremor severity, no correlation was seen with F-Dopa reduction. Furthermore, freezing of gait correlated with reduced F-Dopa uptake in the putamen of the right hemisphere. CONCLUSION AND DISCUSSION:Our results, obtained in a large patient group, provides support for the concept that tremor in PD is not only based on a dopamine related pathway but may rely on a different pathway.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Pikstra ARA,van der Hoorn A,Leenders KL,de Jong BM

doi

10.1016/j.nicl.2016.01.010

subject

Has Abstract

pub_date

2016-01-12 00:00:00

pages

68-72

issn

2213-1582

pii

S2213-1582(16)30009-2

journal_volume

11

pub_type

杂志文章

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