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Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome.

Abstract：

OBJECTIVE:To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS:Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. RESULTS:At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. CONCLUSIONS:Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Blanco-Hinojo L,Pujol J,Esteba-Castillo S,Martínez-Vilavella G,Giménez-Palop O,Gabau E,Casamitjana L,Deus J,Novell R,Caixàs A

doi

10.1016/j.nicl.2019.101662

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

101662

issn

2213-1582

pii

S2213-1582(19)30012-9

journal_volume

21

pub_type

杂志文章

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