Abstract：
:Gilles de la Tourette syndrome (GTS) is a common developmental neuropsychiatric disorder characterized by tics and frequent psychiatric comorbidities, often causing significant disability. Tic generation has been linked to disturbed networks of brain areas involved in planning, controlling and execution of actions, particularly structural and functional disorders in the striatum and cortico-striato-thalamo-cortical loops. We therefore applied structural diffusion tensor imaging (DTI) to characterize changes in intrahemispheric white matter connectivity in cortico-subcortical circuits engaged in motor control in 15 GTS patients without psychiatric comorbidities. White matter connectivity was analyzed by probabilistic fiber tractography between 12 predefined cortical and subcortical regions of interest. Connectivity values were combined with measures of clinical severity rated by the Yale Global Tic Severity Scale (YGTSS). GTS patients showed widespread structural connectivity deficits. Lower connectivity values were found specifically in tracts connecting the supplementary motor areas (SMA) with basal ganglia (pre-SMA-putamen, SMA-putamen) and in frontal cortico-cortical circuits. There was an overall trend towards negative correlations between structural connectivity in these tracts and YGTSS scores. Structural connectivity of frontal brain networks involved in planning, controlling and executing actions is reduced in adult GTS patients which is associated with tic severity. These findings are in line with the concept of GTS as a neurodevelopmental disorder of brain immaturity.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Cheng B,Braass H,Ganos C,Treszl A,Biermann-Ruben K,Hummel FC,Müller-Vahl K,Schnitzler A,Gerloff C,Münchau A,Thomalla Gdoi
10.1016/j.nicl.2013.11.011subject
Has Abstractpub_date
2013-12-07 00:00:00pages
174-81issn
2213-1582pii
S2213-1582(13)00159-9journal_volume
4pub_type
杂志文章abstract：BACKGROUND:Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). OBJECTIVES:The aim of this study is reconstructing the structural connectome to characterize and detec...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101899
更新日期：2019-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1016/j.nicl.2012.10.003.]. ...
journal_title：NeuroImage. Clinical
pub_type： 已发布勘误
doi：10.1016/j.nicl.2013.04.013
更新日期：2013-05-02 00:00:00
abstract：:The electroencephalogram (EEG) constitutes a relevant tool to study neural dynamics and to develop brain-machine interfaces (BMI) for rehabilitation of patients with paralysis due to stroke. However, the EEG is easily contaminated by artifacts of physiological origin, which can pollute the measured cortical activity a...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.09.035
更新日期：2018-01-01 00:00:00
abstract：:Resting state functional connectivity studies of tinnitus have provided inconsistent evidence concerning its neural bases. This may be due to differences in the methodology used, but it is also likely related to the heterogeneity of the tinnitus population. In this study, our goal was to identify resting state functio...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.07.015
更新日期：2017-07-22 00:00:00
abstract：:Apraxia of speech is a motor speech disorder thought to result from impaired planning or programming of articulatory movements. It can be the initial or only manifestation of a degenerative disease, termed primary progressive apraxia of speech (PPAOS). The aim of this study was to use task-free functional magnetic res...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.02.036
更新日期：2018-03-03 00:00:00
abstract：BACKGROUND:Vascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) of moderate or severe extension on brain MRI is the hallmark of the VMCI. OBJECTIVE:To assess the clinical relevance of the frequen...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,多中心研究
doi：10.1016/j.nicl.2019.101789
更新日期：2019-01-01 00:00:00
abstract：:Mutations in the granulin gene (GRN) cause familial frontotemporal dementia. Understanding the structural brain changes in presymptomatic GRN carriers would enforce the use of neuroimaging biomarkers for early diagnosis and monitoring. We studied 100 presymptomatic GRN mutation carriers and 94 noncarriers from the Gen...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102540
更新日期：2020-12-29 00:00:00
abstract：Background:An urgent need exists for faster-acting pharmacological treatments in major depressive disorder (MDD). The glutamatergic modulator ketamine has been shown to have rapid antidepressant effects, but much remains unknown about its mechanism of action. Functional MRI (fMRI) can be used to investigate how ketamin...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.nicl.2018.07.006
更新日期：2018-07-05 00:00:00
abstract：:Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.06.020
更新日期：2016-07-02 00:00:00
abstract：:In order to analyze functional connectivity in untreated and treated patients with schizophrenia, resting-state fMRI data were obtained for whole-brain functional connectivity analysis from 22 first-episode neuroleptic-naïve schizophrenia (NNS), 61 first-episode neuroleptic-treated schizophrenia (NTS) patients, and 60...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.10.004
更新日期：2014-10-16 00:00:00
abstract：:Despite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom predic...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.10.017
更新日期：2018-01-01 00:00:00
abstract：:Simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) is an emerging neuromodulation approach, that enables simultaneous volitional regulation of both hemodynamic (BOLD fMRI) and electrophysiological (EEG) brain activities. Here we report the first application of rtfMRI-EEG-nf for emotion self-regulation t...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102331
更新日期：2020-01-01 00:00:00
abstract：:SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic Paraplegia. The disease has a wide phenotypic variability indicating many regions of the nervous system besides the corticospinal tract are affected. Despite this, anatomical and phenotypic characterization is restricted. In the present stud...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.05.031
更新日期：2018-06-09 00:00:00
abstract：:Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probab...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102019
更新日期：2019-01-01 00:00:00
abstract：:Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of cognitive impairment and dementia. There is increasing awareness that SVD exerts its clinical effects by disrupting white matter connections, predominantly disrupting connections between rich club nodes, a s...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102048
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Hippocampal atrophy has been associated with mild cognitive impairment (MCI) in Parkinson's disease (PD). However, literature on how hippocampal atrophy affects the pathophysiology of cognitive impairment in PD has been limited. Previous studies assessed the hippocampus as an entire entity instead of their in...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.12.008
更新日期：2016-12-12 00:00:00
abstract：PURPOSE:This prospective clinical trial investigated sodium (23Na) MRI at 7 Tesla (T) field strength as biomarker for tumor extent, isocitrate dehydrogenase (IDH) mutation and O6-methylguanine DNA methyltransferase (MGMT) promotor methylation in glioma patients. METHODS:28 glioma patients underwent 23Na MRI on a 7T sc...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102427
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Macro- and micro-structural neuroimaging measures provide valuable information on the pathophysiology of Huntington's disease (HD) and are proposed as biomarkers. Despite theoretical advantages of microstructural measures in terms of sensitivity to pathology, there is little evidence directly comparing the t...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2012.12.001
更新日期：2012-12-09 00:00:00
abstract：:Establishing a reliable correspondence between lesioned brains and a template is challenging using current normalization techniques. The optimum procedure has not been conclusively established, and a critical dichotomy is whether to use input data sets which contain skull signal, or whether skull signal should be remo...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2013.09.007
更新日期：2013-09-30 00:00:00
abstract：:This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102100
更新日期：2020-01-01 00:00:00
abstract：:Multivariate classification is used in neuroimaging studies to infer brain activation or in medical applications to infer diagnosis. Their results are often assessed through either a binomial or a permutation test. Here, we simulated classification results of generated random data to assess the influence of the cross-...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2014.04.004
更新日期：2014-04-13 00:00:00
abstract：:Using quantitative T2* at 7 Tesla (T) magnetic resonance imaging, we investigated whether impairment in selective cognitive functions in multiple sclerosis (MS) can be explained by pathology in specific areas and/or layers of the cortex. Thirty-one MS patients underwent neuropsychological evaluation, acquisition of 7 ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2016.11.001
更新日期：2016-11-03 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Quantitative MRI (qMRI) permits the quantification of brain changes compatible with inflammation, degeneration and repair in multiple sclerosis (MS) patients. In this study, we propose a new method to provide personalized maps of tissue alterations and longitudinal brain changes based on diffe...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.11.017
更新日期：2019-01-01 00:00:00
abstract：:Etiological explanations of clinical anxiety can be advanced through understanding the neural mechanisms associated with anxiety in youth prior to the emergence of psychopathology. In this vein, the present study sought to investigate how trait anxiety is related to features of the structural connectome in early adole...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2017.09.012
更新日期：2017-09-21 00:00:00
abstract：BACKGROUND:Current diagnostic systems for neurodevelopmental disorders do not have clear links to underlying neurobiology, limiting their utility in identifying targeted treatments for individuals. Here, we aimed to investigate differences in functional brain network integrity between traditional diagnostic categories ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.101678
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVES:Insomnia disorder has been reclassified into short-term/acute and chronic subtypes based on recent etiological advances. However, understanding the similarities and differences in the neural mechanisms underlying the two subtypes and accurately predicting the sleep quality remain challenging. METHODS:Using ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102439
更新日期：2020-01-01 00:00:00
abstract：:Cerebral Microbleeds (CMBs) are small chronic brain hemorrhages, which have been considered as diagnostic indicators for different cerebrovascular diseases including stroke, dysfunction, dementia, and cognitive impairment. However, automated detection and identification of CMBs in Magnetic Resonance (MR) images is a v...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2020.102464
更新日期：2020-01-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is a trauma- and stressor-related disorder that may emerge following a traumatic event. Neuroimaging studies have shown evidence of functional abnormality in many brain regions and systems affected by PTSD. Exaggerated threat detection associated with abnormalities in the salience ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2018.04.014
更新日期：2018-04-21 00:00:00
abstract：:Epilepsy affects 65 million people worldwide, a third of whom have seizures that are resistant to anti-epileptic medications. Some of these patients may be amenable to surgical therapy or treatment with implantable devices, but this usually requires delineation of discrete structural or functional lesion(s), which is ...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章,评审
doi：10.1016/j.nicl.2016.02.013
更新日期：2016-02-23 00:00:00
abstract：:We assessed first-year hippocampal atrophy in stroke patients and healthy controls using manual and automated segmentations: AdaBoost, FIRST (fsl/v5.0.8), FreeSurfer/v5.3 and v6.0, and Subfields (in FreeSurfer/v6.0). We estimated hippocampal volumes in 39 healthy controls and 124 stroke participants at three months, a...
journal_title：NeuroImage. Clinical
pub_type： 杂志文章
doi：10.1016/j.nicl.2019.102008
更新日期：2019-01-01 00:00:00
