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Ketamine normalizes brain activity during emotionally valenced attentional processing in depression.

Abstract：

Background:An urgent need exists for faster-acting pharmacological treatments in major depressive disorder (MDD). The glutamatergic modulator ketamine has been shown to have rapid antidepressant effects, but much remains unknown about its mechanism of action. Functional MRI (fMRI) can be used to investigate how ketamine impacts brain activity during cognitive and emotional processing. Methods:This double-blind, placebo-controlled, crossover study of 33 unmedicated participants with MDD and 26 healthy controls (HCs) examined how ketamine affected fMRI activation during an attentional bias dot probe task with emotional face stimuli across multiple time points. A whole brain analysis was conducted to find regions with differential activation associated with group, drug session, or dot probe task-specific factors (emotional valence and congruency of stimuli). Results:A drug session by group interaction was observed in several brain regions, such that ketamine had opposite effects on brain activation in MDD versus HC participants. Additionally, there was a similar finding related to emotional valence (a drug session by group by emotion interaction) in a large cluster in the anterior cingulate and medial frontal cortex. Conclusions:The findings show a pattern of brain activity in MDD participants following ketamine infusion that is similar to activity observed in HCs after placebo. This suggests that ketamine may act as an antidepressant by normalizing brain function during emotionally valenced attentional processing. Clinical trial:NCT#00088699: https://www.clinicaltrials.gov/ct2/show/NCT00088699.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Reed JL,Nugent AC,Furey ML,Szczepanik JE,Evans JW,Zarate CA Jr

doi

10.1016/j.nicl.2018.07.006

subject

Has Abstract

pub_date

2018-07-05 00:00:00

pages

92-101

issn

2213-1582

pii

S2213-1582(18)30218-3

journal_volume

20

pub_type

杂志文章,随机对照试验

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