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White matter microstructure correlates of general and specific second-order factors of psychopathology.

Abstract：

:Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless, most existing studies on the neural correlates of psychopathology employ case-control designs that treat diagnoses as independent categories, ignoring the highly correlated nature of psychopathology. Thus, for instance, although perturbations in white matter microstructure have been identified across a range of mental disorders, nearly all such studies used case-control designs, leaving it unclear whether observed relations reflect disorder-specific characteristics or transdiagnostic associations. Using a representative sample of 410 young adult twins oversampled for psychopathology risk, we tested the hypothesis that some previously observed relations between white matter microstructure properties in major tracts and specific disorders are related to second-order factors of psychopathology. We examined fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). White matter correlates of all second-order factors were identified after controlling for multiple statistical tests, including the general factor (FA in the body of the corpus callosum), specific internalizing (AD in the fornix), and specific externalizing (AD in the splenium of the corpus callosum, sagittal stratum, anterior corona radiata, and internal capsule). These findings suggest that some features of white matter within specific tracts may be transdiagnostically associated multiple forms of psychopathology through second-order factors of psychopathology rather with than individual mental disorders.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Hinton KE,Lahey BB,Villalta-Gil V,Meyer FAC,Burgess LL,Chodes LK,Applegate B,Van Hulle CA,Landman BA,Zald DH

doi

10.1016/j.nicl.2019.101705

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

101705

issn

2213-1582

pii

S2213-1582(19)30055-5

journal_volume

22

pub_type

杂志文章

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