Abstract：
:Schizophrenia is associated with a number of cognitive impairments such as deficient sensory encoding or working memory processing. However, it is largely unclear how dysfunctions on these various levels of cortical processing contribute to alterations of stimulus-specific information representation. To test this, we used a well-established sequential frequency comparison paradigm, in which sensory encoding of vibrotactile stimuli can be assessed via frequency-specific steady-state evoked potentials (SSEPs) over primary somatosensory cortex (S1). Further, we investigated the maintenance of frequency information in working memory (WM) in terms of parametric power modulations of induced beta-band EEG oscillations. In the present study schizophrenic patients showed significantly less pronounced SSEPs during vibrotactile stimulation than healthy controls. In particular, inter-trial phase coherence was reduced. While maintaining vibrotactile frequencies in WM, patients showed a significantly weaker prefrontal beta-power modulation compared to healthy controls. Crucially, patients exhibited no general disturbances in attention, as inferred from a behavioral test and from alpha-band event-related synchronization. Together, our results provide novel evidence that patients with schizophrenia show altered neural correlates of stimulus-specific sensory encoding and WM maintenance, suggesting an early somatosensory impairment as well as alterations in the formation of abstract representations of task-relevant stimulus information.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Ludwig S,Spitzer B,Jacobs AM,Sekutowicz M,Sterzer P,Blankenburg Fdoi
10.1016/j.nicl.2016.04.004subject
Has Abstractpub_date
2016-04-12 00:00:00pages
578-587issn
2213-1582pii
S2213-1582(16)30067-5journal_volume
11pub_type
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