Abstract:
BACKGROUND:The history of immune suppression, especially CD4 nadir, has been shown to be a strong predictor of HIV-associated neurocognitive disorders (HAND). However, the potential mechanism of this association is not well understood. METHODS:High resolution structural MRI images and neuropsychological data were obtained from fifty-nine HIV+ adults (mean age, 56.5 ± 5.8) to investigate the correlation between CD4 nadir and cortical thickness. RESULTS:Low CD4 nadir was associated with widespread cortical thinning, especially in the frontal and temporal regions, and global mean cortical thickness correlated with CD4 nadir. In addition, worse global neurocognitive function was associated with bilateral frontal cortical thinning, and the association largely persisted (especially in the left frontal cortex) in the subset of participants who did not meet HAND criteria. CONCLUSIONS:These results suggest that low CD4 nadir may be associated with widespread neural injury in the brain, especially in the frontal and temporal regions. The diffuse neural injury might contribute to the prevalence and the phenotypes of HAND, as well as the difficulty treating HAND due to a broad network of brain regions affected. Low CD4 nadir related neural injury to the frontal cortex might contribute to subtle neurocognitive impairment/decline, even in the absence of HAND diagnosis.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Hassanzadeh-Behbahani S,Shattuck KF,Bronshteyn M,Dawson M,Diaz M,Kumar P,Moore DJ,Ellis RJ,Jiang Xdoi
10.1016/j.nicl.2019.102155subject
Has Abstractpub_date
2020-01-01 00:00:00pages
102155issn
2213-1582pii
S2213-1582(19)30501-7journal_volume
25pub_type
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