Abstract:
:This paper examines morphometry of MRI biomarkers derived from the network of temporal lobe structures including the amygdala, entorhinal cortex and hippocampus in subjects with preclinical Alzheimer's disease (AD). Based on template-centered population analysis, it is demonstrated that the structural markers of the amygdala, hippocampus and entorhinal cortex are statistically significantly different between controls and those with preclinical AD. Entorhinal cortex is the most strongly significant based on the linear effects model (p < .0001) for the high-dimensional vertex- and Laplacian-based markers corresponding to localized atrophy. The hippocampus also shows significant localized high-dimensional change (p < .0025) and the amygdala demonstrates more global change signaled by the strength of the low-dimensional volume markers. The analysis of the three structures also demonstrates that the volume measures are only weakly discriminating between preclinical and control groups, with the average atrophy rates of the volume of the entorhinal cortex higher than amygdala and hippocampus. The entorhinal cortex thickness also exhibits an atrophy rate nearly a factor of two higher in the ApoE4 positive group relative to the ApoE4 negative group providing weak discrimination between the two groups.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Miller MI,Younes L,Ratnanather JT,Brown T,Trinh H,Postell E,Lee DS,Wang MC,Mori S,O'Brien R,Albert M,BIOCARD Research Team.doi
10.1016/j.nicl.2013.09.001subject
Has Abstractpub_date
2013-09-16 00:00:00pages
352-60issn
2213-1582pii
S2213-1582(13)00118-6journal_volume
3pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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