当前位置： SCI文献检索 > NeuroImage-Clinical期刊下所有文献 > Measuring longitudinal myelin water fraction in new multiple sclerosis lesions.

Measuring longitudinal myelin water fraction in new multiple sclerosis lesions.

Abstract：

OBJECTIVES:Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF), an MRI biomarker of myelin, in new MS lesions and to identify factors that influence their subsequent myelin content. METHODS:Twenty-three MS patients were scanned with whole-brain Fast Acquisition with Spiral Trajectory and T2prep (FAST-T2) MWF mapping at baseline and median follow-up of 6 months. Eleven healthy controls (HC) confirmed the reproducibility of FAST-T2 in white matter regions of interests (ROIs) similar to a lesion size. A random-effect-model was implemented to determine the association between baseline clinical and lesion variables and the subsequent MWF. RESULTS:ROI-based measurements in HCs were highly correlated between scans [mean r = 0.893 (.764-.967)]. In MS patients, 38 gadolinium enhancing (Gd+) and 25 new non-enhancing (Gd-) T2 hyperintense lesions (5.7 months, ±3.8) were identified. Significant improvement in MWF was seen in Gd+ lesions (0.035 ± 0.029, p < 0.001) as compared to Gd- lesions (0.006 ± 0.017, p = 0.065). In the model, a higher baseline MWF (p < 0.001) and the presence of Gd (p < 0.001) were associated with higher subsequent MWF. CONCLUSIONS:FAST T2 provides a clinically feasible method to quantify MWF in new MS lesions. The observed influence of baseline MWF, which represents a combined effect of both resolving edema and myelin change within acute lesions, suggests that the extent of initial inflammation impacts final myelin recovery.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Vargas WS,Monohan E,Pandya S,Raj A,Vartanian T,Nguyen TD,Hurtado Rúa SM,Gauthier SA

doi

10.1016/j.nicl.2015.09.003

subject

Has Abstract

pub_date

2015-09-12 00:00:00

pages

369-75

issn

2213-1582

pii

S2213-1582(15)00163-1

journal_volume

9

pub_type

杂志文章

相关文献

NeuroImage-Clinical文献大全
  • Evaluation of multi-modal, multi-site neuroimaging measures in Huntington's disease: Baseline results from the PADDINGTON study.

    abstract：BACKGROUND:Macro- and micro-structural neuroimaging measures provide valuable information on the pathophysiology of Huntington's disease (HD) and are proposed as biomarkers. Despite theoretical advantages of microstructural measures in terms of sensitivity to pathology, there is little evidence directly comparing the t...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2012.12.001

    authors： Hobbs NZ,Cole JH,Farmer RE,Rees EM,Crawford HE,Malone IB,Roos RA,Sprengelmeyer R,Durr A,Landwehrmeyer B,Scahill RI,Tabrizi SJ,Frost C

    更新日期：2012-12-09 00:00:00

  • Multiparametric graph theoretical analysis reveals altered structural and functional network topology in Alzheimer's disease.

    abstract：:Alzheimer's disease (AD), an irreversible neurodegenerative disease, is the most common type of dementia in elderly people. This present study incorporated multiple structural and functional connectivity metrics into a graph theoretical analysis framework and investigated alterations in brain network topology in patie...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101680

    authors： Lin SY,Lin CP,Hsieh TJ,Lin CF,Chen SH,Chao YP,Chen YS,Hsu CC,Kuo LW

    更新日期：2019-01-01 00:00:00

  • Transcranial direct current stimulation modulates brain functional connectivity in autism.

    abstract：:Autism spectrum disorder (ASD) is characterized by deficits in social interactions, impairments in language and communication, and highly restricted behavioral interests. Transcranial direct current stimulation (tDCS) is a widely used form of noninvasive stimulation and may have therapeutic potential for ASD. So far, ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102500

    authors： Zhou T,Kang J,Li Z,Chen H,Li X

    更新日期：2020-01-01 00:00:00

  • Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study.

    abstract：:Children and adolescents with congenital heart disease (CHD) are at risk for mild to moderate cognitive impairments. In particular, impaired working memory performance has been found in CHD patients of all ages. Working memory is an important domain of higher order cognitive function and is crucial for everyday activi...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102123

    authors： Ehrler M,Latal B,Kretschmar O,von Rhein M,O'Gorman Tuura R

    更新日期：2020-01-01 00:00:00

  • Cerebellar-cortical function and connectivity during sensorimotor behavior in aging FMR1 gene premutation carriers.

    abstract：INTRODUCTION:Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as well as cerebellar and cerebral white matter pathology. Several studies have documented preclinical ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102332

    authors： McKinney WS,Bartolotti J,Khemani P,Wang JY,Hagerman RJ,Mosconi MW

    更新日期：2020-01-01 00:00:00

  • Longitudinal decrease in blood oxygenation level dependent response in cerebral amyloid angiopathy.

    abstract：:Lower blood oxygenation level dependent (BOLD) signal changes in response to a visual stimulus in functional magnetic resonance imaging (fMRI) have been observed in cross-sectional studies of cerebral amyloid angiopathy (CAA), and are presumed to reflect impaired vascular reactivity. We used fMRI to detect a longitudi...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.02.020

    authors： Switzer AR,McCreary C,Batool S,Stafford RB,Frayne R,Goodyear BG,Smith EE

    更新日期：2016-03-03 00:00:00

  • Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system.

    abstract：OBJECTIVE:To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission. BACKGROUND:CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medication use, including opioids. METHODS:We scanned 15 migraine patients d...

    journal_title：NeuroImage. Clinical

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.nicl.2019.101905

    authors： Jassar H,Nascimento TD,Kaciroti N,DosSantos MF,Danciu T,Koeppe RA,Smith YR,Bigal ME,Porreca F,Casey KL,Zubieta JK,DaSilva AF

    更新日期：2019-01-01 00:00:00

  • Periventricular white matter abnormalities and restricted repetitive behavior in autism spectrum disorder.

    abstract：:Malformations of cortical development are found at higher rates in autism spectrum disorder (ASD) than in healthy controls on postmortem neuropathological evaluation but are more variably observed on visual review of in-vivo MRI brain scans. This may be due to the visually elusive nature of many malformations on MRI. ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.10.017

    authors： Blackmon K,Ben-Avi E,Wang X,Pardoe HR,Di Martino A,Halgren E,Devinsky O,Thesen T,Kuzniecky R

    更新日期：2015-10-31 00:00:00

  • Predicting primary progressive aphasias with support vector machine approaches in structural MRI data.

    abstract：:Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging da...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.02.003

    authors： Bisenius S,Mueller K,Diehl-Schmid J,Fassbender K,Grimmer T,Jessen F,Kassubek J,Kornhuber J,Landwehrmeyer B,Ludolph A,Schneider A,Anderl-Straub S,Stuke K,Danek A,Otto M,Schroeter ML,FTLDc study group.

    更新日期：2017-02-06 00:00:00

  • Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks.

    abstract：:The cerebellum plays an important role in motor learning as part of a cortico-striato-cerebellar network. Patients with cerebellar degeneration typically show impairments in different aspects of motor learning, including implicit motor sequence learning. How cerebellar dysfunction affects interactions in this cortico-...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.07.012

    authors： Tzvi E,Zimmermann C,Bey R,Münte TF,Nitschke M,Krämer UM

    更新日期：2017-07-15 00:00:00

  • Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms.

    abstract：:Approximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hyp...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102217

    authors： Bohorquez-Montoya L,España LY,Nader AM,Furger RE,Mayer AR,Meier TB

    更新日期：2020-01-01 00:00:00

  • Cortical thinning in military blast compared to non-blast persistent mild traumatic brain injuries.

    abstract：:In the military, explosive blasts are a significant cause of mild traumatic brain injuries (mTBIs). The symptoms associated with blast mTBIs causes significant economic burdens and a diminished quality of life for many service members. At present, the distinction of the injury mechanism (blast versus non-blast) may no...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101793

    authors： Eierud C,Nathan DE,Bonavia GH,Ollinger J,Riedy G

    更新日期：2019-01-01 00:00:00

  • Premature white matter aging in patients with right mesial temporal lobe epilepsy: A machine learning approach based on diffusion MRI data.

    abstract：:Brain age prediction based on machine learning has been applied to various neurological diseases to discover its clinical values. By this innovative approach, it has been reported that the patients with refractory epilepsy had premature brain aging. Of refractory epilepsy, right and left subtypes of mesial temporal lo...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102033

    authors： Chen CL,Shih YC,Liou HH,Hsu YC,Lin FH,Tseng WI

    更新日期：2019-01-01 00:00:00

  • Dysfunction of attention switching networks in amyotrophic lateral sclerosis.

    abstract：OBJECTIVE:To localise and characterise changes in cognitive networks in Amyotrophic Lateral Sclerosis (ALS) using source analysis of mismatch negativity (MMN) waveforms. RATIONALE:The MMN waveform has an increased average delay in ALS. MMN has been attributed to change detection and involuntary attention switching. Th...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101707

    authors： McMackin R,Dukic S,Broderick M,Iyer PM,Pinto-Grau M,Mohr K,Chipika R,Coffey A,Buxo T,Schuster C,Gavin B,Heverin M,Bede P,Pender N,Lalor EC,Muthuraman M,Hardiman O,Nasseroleslami B

    更新日期：2019-01-01 00:00:00

  • Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study.

    abstract：BACKGROUND:Insight is impaired in the majority of schizophrenia patients. The exact neural correlates of impaired insight remain unclear. We assume that the ability to regulate emotions contributes to having good clinical insight, as patients should be able to regulate their emotional state in such a way that they can ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.09.009

    authors： Larabi DI,van der Meer L,Pijnenborg GHM,Ćurčić-Blake B,Aleman A

    更新日期：2018-01-01 00:00:00

  • Prediction of cognitive and motor development in preterm children using exhaustive feature selection and cross-validation of near-term white matter microstructure.

    abstract：Background:Advanced neuroimaging and computational methods offer opportunities for more accurate prognosis. We hypothesized that near-term regional white matter (WM) microstructure, assessed on diffusion tensor imaging (DTI), using exhaustive feature selection with cross-validation would predict neurodevelopment in pre...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.11.023

    authors： Schadl K,Vassar R,Cahill-Rowley K,Yeom KW,Stevenson DK,Rose J

    更新日期：2017-11-29 00:00:00

  • Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study.

    abstract：BACKGROUND:Impaired cognitive flexibility has been implicated in the genetic basis of obsessive-compulsive disorder (OCD). Recent endophenotype studies of OCD showed neural inefficiency in the cognitive control network and interference by the limbic network of the cognitive control network. Exploring the relationship b...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102004

    authors： Tomiyama H,Nakao T,Murayama K,Nemoto K,Ikari K,Yamada S,Kuwano M,Hasuzawa S,Togao O,Hiwatashi A,Kanba S

    更新日期：2019-01-01 00:00:00

  • Impact of schizophrenia on anterior and posterior hippocampus during memory for complex scenes.

    abstract：OBJECTIVES:Hippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionatel...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.11.017

    authors： Ragland JD,Layher E,Hannula DE,Niendam TA,Lesh TA,Solomon M,Carter CS,Ranganath C

    更新日期：2016-11-17 00:00:00

  • Common folate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment.

    abstract：:A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people carrying the C677T MTHFR polymorphism which increases homocyste...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2012.09.012

    authors： Rajagopalan P,Jahanshad N,Stein JL,Hua X,Madsen SK,Kohannim O,Hibar DP,Toga AW,Jack CR Jr,Saykin AJ,Green RC,Weiner MW,Bis JC,Kuller LH,Riverol M,Becker JT,Lopez OL,Thompson PM,Alzheimer's Disease Neuroimaging Initiat

    更新日期：2012-10-04 00:00:00

  • The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease.

    abstract：:This paper examines morphometry of MRI biomarkers derived from the network of temporal lobe structures including the amygdala, entorhinal cortex and hippocampus in subjects with preclinical Alzheimer's disease (AD). Based on template-centered population analysis, it is demonstrated that the structural markers of the a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.09.001

    authors： Miller MI,Younes L,Ratnanather JT,Brown T,Trinh H,Postell E,Lee DS,Wang MC,Mori S,O'Brien R,Albert M,BIOCARD Research Team.

    更新日期：2013-09-16 00:00:00

  • Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI.

    abstract：:Sporadic cerebral small vessel disease is an important cause of vascular dementia, a syndrome of cognitive impairment together with vascular brain damage. At post-mortem pure vascular dementia is rare, with evidence of co-existing Alzheimer's disease pathology in 95% of cases. This work used MRI to characterize struct...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.06.023

    authors： Lambert C,Zeestraten E,Williams O,Benjamin P,Lawrence AJ,Morris RG,Mackinnon AD,Barrick TR,Markus HS

    更新日期：2018-06-20 00:00:00

  • Neural correlates of attention bias to masked facial threat cues: Examining children at-risk for social anxiety disorder.

    abstract：Background:Behavioral inhibition (BI) is an early-appearing temperament trait and a robust predictor of social anxiety disorder (SAD). Both BI and anxiety may have distinct patterns of emotion processing marked by heightened neural responses to threat cues. BI and anxious children display similar frontolimbic patterns ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.04.003

    authors： Auday ES,Taber-Thomas BC,Pérez-Edgar KE

    更新日期：2018-04-12 00:00:00

  • Reading related white matter structures in adolescents are influenced more by dysregulation of emotion than behavior.

    abstract：:Mood disorders and behavioral are broad psychiatric diagnostic categories that have different symptoms and neurobiological mechanisms, but share some neurocognitive similarities, one of which is an elevated risk for reading deficit. Our aim was to determine the influence of mood versus behavioral dysregulation on read...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.06.020

    authors： Horowitz-Kraus T,Holland SK,Versace AL,Bertocci MA,Bebko G,Almeida JRC,Perlman SB,Travis MJ,Gill MK,Bonar L,Schirda C,Sunshine JL,Birmaher B,Taylor G,Diwadkar VA,Horwitz SM,Axelson D,Frazier T,Arnold EL,Fristad MA,

    更新日期：2017-06-23 00:00:00

  • Structural connectomics of anxious arousal in early adolescence: Translating clinical and ethological findings.

    abstract：:Etiological explanations of clinical anxiety can be advanced through understanding the neural mechanisms associated with anxiety in youth prior to the emergence of psychopathology. In this vein, the present study sought to investigate how trait anxiety is related to features of the structural connectome in early adole...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.09.012

    authors： Sharp PB,Telzer EH

    更新日期：2017-09-21 00:00:00

  • Identifying motor functional neurological disorder using resting-state functional connectivity.

    abstract：BACKGROUND:Motor functional neurological disorder (mFND) is a clinical diagnosis with reliable features; however, patients are reluctant to accept the diagnosis and physicians themselves bear doubts on potential misdiagnoses. The identification of a positive biomarker could help limiting unnecessary costs of multiple r...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.10.012

    authors： Wegrzyk J,Kebets V,Richiardi J,Galli S,de Ville DV,Aybek S

    更新日期：2017-10-12 00:00:00

  • Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.

    abstract：:The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.07.008

    authors： Bagshaw AP,Hale JR,Campos BM,Rollings DT,Wilson RS,Alvim MKM,Coan AC,Cendes F

    更新日期：2017-07-12 00:00:00

  • Disrupted structural connectivity of fronto-deep gray matter pathways in progressive supranuclear palsy.

    abstract：BACKGROUND:Structural connectivity is a promising methodology to detect patterns of neural network dysfunction in neurodegenerative diseases. This approach has not been tested in progressive supranuclear palsy (PSP). OBJECTIVES:The aim of this study is reconstructing the structural connectome to characterize and detec...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101899

    authors： Abos A,Segura B,Baggio HC,Campabadal A,Uribe C,Garrido A,Camara A,Muñoz E,Valldeoriola F,Marti MJ,Junque C,Compta Y

    更新日期：2019-01-01 00:00:00

  • Draining the pond and catching the fish: Uncovering the ecosystem of auditory verbal hallucinations.

    abstract：:The various models proposed for the mediation of auditory verbal hallucinations (AVH) implicate a considerable number of brain areas and mechanisms. To establish which of those mechanisms are actually involved in the mediation of AVH, we developed a novel method to analyze functional MRI data, which allows for the det...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.09.016

    authors： Looijestijn J,Blom JD,Hoek HW,Renken R,Liemburg E,Sommer IEC,Aleman A,Goekoop R

    更新日期：2018-01-01 00:00:00

  • Improving the detection of autism spectrum disorder by combining structural and functional MRI information.

    abstract：:Autism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detectio...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102181

    authors： Rakić M,Cabezas M,Kushibar K,Oliver A,Lladó X

    更新日期：2020-01-01 00:00:00

  • Fibromyalgia interacts with age to change the brain.

    abstract：:Although brain plasticity in the form of gray matter increases and decreases has been observed in chronic pain, factors determining the patterns of directionality are largely unknown. Here we tested the hypothesis that fibromyalgia interacts with age to produce distinct patterns of gray matter differences, specificall...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.08.015

    authors： Ceko M,Bushnell MC,Fitzcharles MA,Schweinhardt P

    更新日期：2013-09-06 00:00:00