Abstract:
:Sporadic cerebral small vessel disease is an important cause of vascular dementia, a syndrome of cognitive impairment together with vascular brain damage. At post-mortem pure vascular dementia is rare, with evidence of co-existing Alzheimer's disease pathology in 95% of cases. This work used MRI to characterize structural abnormalities during the preclinical phase of vascular dementia in symptomatic small vessel disease. 121 subjects were recruited into the St George's Cognition and Neuroimaging in Stroke study and followed up longitudinally for five years. Over this period 22 individuals converted to dementia. Using voxel-based morphometry, we found structural abnormalities present at baseline in those with preclinical dementia, with reduced grey matter density in the left striatum and hippocampus, and more white matter hyperintensities in the frontal white-matter. The lacunar data revealed that some of these abnormalities may be due to lesions within the striatum and centrum semiovale. Using support vector machines, future dementia could be best predicted using hippocampal and striatal Jacobian determinant data, achieving a balanced classification accuracy of 73%. Using cluster ward linkage we identified four anatomical subtypes. Successful predictions were restricted to groups with lower levels of vascular damage. The subgroup that could not be predicted were younger, further from conversion, had the highest levels of vascular damage, with milder cognitive impairment at baseline but more rapid deterioration in processing speed and executive function, consistent with a primary vascular dementia. In contrast, the remaining groups had decreasing levels of vascular damage and increasing memory impairment consistent with progressively more Alzheimer's-like pathology. Voxel-wise rates of hippocampal atrophy supported these distinctions, with the vascular group closely resembling the non-dementing cohort, whereas the Alzheimer's like group demonstrated global hippocampal atrophy. This work reveals distinct anatomical endophenotypes in preclinical vascular dementia, forming a spectrum between vascular and Alzheimer's like pathology. The latter group can be identified using baseline MRI, with 73% converting within 5 years. It was not possible to predict the vascular dominant dementia subgroup, however 19% of negative predictions with high levels of vascular disease would ultimately develop dementia. It may be that techniques more sensitive to white matter damage, such as diffusion weighted imaging, may prove more useful for this vascular dominant subgroup in the future. This work provides a way to accurately stratify patients using a baseline MRI scan, and has utility in future clinical trials designed to slow or prevent the onset of dementia in these high-risk cohorts.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Lambert C,Zeestraten E,Williams O,Benjamin P,Lawrence AJ,Morris RG,Mackinnon AD,Barrick TR,Markus HSdoi
10.1016/j.nicl.2018.06.023subject
Has Abstractpub_date
2018-06-20 00:00:00pages
925-938issn
2213-1582pii
S2213-1582(18)30206-7journal_volume
19pub_type
杂志文章abstract:BACKGROUND:Individuals with at-risk mental state for psychosis (ARMS) often suffer from depressive and anxiety symptoms, which are clinically similar to the negative symptomatology described for psychosis. Thus, many ARMS individuals are already being treated with antidepressant medication. OBJECTIVES:To investigate c...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.04.016
更新日期:2015-04-29 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Quantitative MRI (qMRI) permits the quantification of brain changes compatible with inflammation, degeneration and repair in multiple sclerosis (MS) patients. In this study, we propose a new method to provide personalized maps of tissue alterations and longitudinal brain changes based on diffe...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.11.017
更新日期:2019-01-01 00:00:00
abstract::When differential diagnosis of dementia includes both Alzheimer's disease (AD) and the behavioural variant of frontotemporal dementia (bvFTD), distribution of cerebral glucose metabolism as measured using [18F]‑2‑fluoro‑2‑deoxy‑d‑glucose positron emission tomography ([18F]FDG-PET) may be helpful. One important clue fo...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.05.024
更新日期:2018-05-22 00:00:00
abstract:INTRODUCTION:Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a vali...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.06.034
更新日期:2017-06-30 00:00:00
abstract:Background:The hippocampus has recently been identified to play a key role in the pathophysiology of adult obsessive-compulsive disorder (OCD). Surprisingly, there is only limited evidence regarding the potential relationships with symptom dimensions. Due to the heterogeneity of symptoms in OCD, we aimed at further exa...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.11.006
更新日期:2017-11-08 00:00:00
abstract::Increased reaction time intra-subject variability (RT-ISV) in fast decision tasks has been confirmed in patients with schizophrenia and has been hypothesized to result from a deficit in the control of attention. Here, an attentional task and functional brain imaging were used to probe the neural correlates of increase...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101853
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Differentiation between self-produced tactile stimuli and touch by others is necessary for social interactions and for a coherent concept of "self". In attention-deficit-hyperactivity-disorder (ADHD), tactile hypersensitivity and social cognition problems are part of the symptomatology, but pathophysiologi...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102317
更新日期:2020-01-01 00:00:00
abstract::Autism Spectrum Disorder (ASD) is characterized by impairments in language and social-emotional cognition. Yet, findings of emotion recognition from affective prosody in individuals with ASD are inconsistent. This study investigated emotion recognition and neural processing of affective prosody in high-functioning adu...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.08.025
更新日期:2014-10-05 00:00:00
abstract::Cerebral Microbleeds (CMBs) are small chronic brain hemorrhages, which have been considered as diagnostic indicators for different cerebrovascular diseases including stroke, dysfunction, dementia, and cognitive impairment. However, automated detection and identification of CMBs in Magnetic Resonance (MR) images is a v...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2020.102464
更新日期:2020-01-01 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is a disabling disorder associated with resting state functional connectivity alterations. However, whether specific brain regions are altered in PTSD or whether the whole brain network organization differs remains unclear. PTSD can be treated with trauma-focused therapy, although ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.12.008
更新日期:2015-12-18 00:00:00
abstract::Increasing data indicate that prevalent forms of psychopathology can be organized into second-order dimensions based on their correlations, including a general factor of psychopathology that explains the common variance among all disorders and specific second-order externalizing and internalizing factors. Nevertheless...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101705
更新日期:2019-01-01 00:00:00
abstract::Methamphetamine use disorder is associated with a high likelihood of relapse. Identifying robust predictors of relapse that have explanatory power is critical to develop secondary prevention based on a mechanistic understanding of relapse. Computational approaches have the potential to identify such predictive markers...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101794
更新日期:2019-01-01 00:00:00
abstract::Anxiety disorders have been linked to a hyperactivated cortico-amygdalar circuitry. Recent findings highlight the amygdala's role in mediating elevated anxiety in obsessive-compulsive disorder (OCD). However, modulation of amygdala hyperactivation by attentional distraction - an effective emotion regulation strategy i...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.03.011
更新日期:2014-03-26 00:00:00
abstract::Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twe...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.01.020
更新日期:2017-01-23 00:00:00
abstract::Neuropsychological assessment, brain imaging and computational modelling have augmented our understanding of the multifaceted functional deficits in people with language disorders after stroke. Despite the volume of research using each technique, no studies have attempted to assimilate all three approaches in order to...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.03.031
更新日期:2018-03-27 00:00:00
abstract::In the military, explosive blasts are a significant cause of mild traumatic brain injuries (mTBIs). The symptoms associated with blast mTBIs causes significant economic burdens and a diminished quality of life for many service members. At present, the distinction of the injury mechanism (blast versus non-blast) may no...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101793
更新日期:2019-01-01 00:00:00
abstract::Recent evidence suggests that immobilization of the upper limb for 2-3 weeks induces changes in cortical thickness as well as motor performance. In constraint induced (CI) therapy, one of the most effective interventions for hemiplegia, the non-paretic arm is constrained to enforce the use of the paretic arm in the ho...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2013.05.005
更新日期:2013-05-21 00:00:00
abstract::Biomarkers in whichever modality are tremendously important in diagnosing of disease, tracking disease progression and clinical trials. This applies in particular for disorders with a long disease course including pre-symptomatic stages, in which only subtle signs of clinical progression can be observed. Magnetic reso...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章,评审
doi:10.1016/j.nicl.2018.03.013
更新日期:2018-03-16 00:00:00
abstract:BACKGROUND:Various types of multiple sclerosis (MS) related pain have been discussed. One concept is that deafferentation secondary to lesions in the spino-thalamo-cortical network can cause central pain. However, this hypothesis is somehow limited by a lack of a robust association between pain episodes and sites of le...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2013.01.008
更新日期:2013-01-28 00:00:00
abstract::Primary progressive aphasia (PPA) encompasses the three subtypes nonfluent/agrammatic variant PPA, semantic variant PPA, and the logopenic variant PPA, which are characterized by distinct patterns of language difficulties and regional brain atrophy. To validate the potential of structural magnetic resonance imaging da...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.02.003
更新日期:2017-02-06 00:00:00
abstract::A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people carrying the C677T MTHFR polymorphism which increases homocyste...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2012.09.012
更新日期:2012-10-04 00:00:00
abstract::In Alzheimer's disease (AD), the hippocampus is an early site of tau pathology and neurodegeneration. Histological studies have shown that lesions are not uniformly distributed within the hippocampus. Moreover, alterations of different hippocampal layers may reflect distinct pathological processes. 7 T MRI dramaticall...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.07.011
更新日期:2014-07-31 00:00:00
abstract::The primary objective of this study was to evaluate changes in cerebral blood flow (CBF) using arterial spin labeling MRI between day 4 of life (DOL4) and day 11 of life (DOL11) in neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia. The secondary objectives were to compare CBF values between ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101939
更新日期:2019-01-01 00:00:00
abstract::SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic Paraplegia. The disease has a wide phenotypic variability indicating many regions of the nervous system besides the corticospinal tract are affected. Despite this, anatomical and phenotypic characterization is restricted. In the present stud...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.05.031
更新日期:2018-06-09 00:00:00
abstract::Selecting a set of relevant markers to predict conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) has become a challenging task given the wealth of regional pathologic information that can be extracted from multimodal imaging data. Here, we used regularized regression approaches with an elasti...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.05.006
更新日期:2015-05-21 00:00:00
abstract:OBJECTIVE:Parkinson's disease (PD) episodic memory impairments are common; however, it is not known whether these impairments are due to hippocampal pathology. Hippocampal Lewy-bodies emerge by Braak stage 4, but are not uniformly distributed. For instance, hippocampal CA1 Lewy-body pathology has been specifically asso...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101824
更新日期:2019-01-01 00:00:00
abstract::Network functioning during cognitive tasks is of major interest in Alzheimer's disease (AD). Cognitive functioning in AD includes variable performance in short-term memory (STM). In most studies, the verbal STM functioning in AD patients has been interpreted within the phonological loop subsystem of Baddeley's working...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101892
更新日期:2019-01-01 00:00:00
abstract::Hyperactivation, which is defined as a higher level of activation in patients compared to cognitively unimpaired older adults (controls; CTL), might represent an early signature of Alzheimer's Disease (AD). The goal of this study was to assess the presence and location of hyperactivation in individuals with mild cogni...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101958
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Current diagnostic systems for neurodevelopmental disorders do not have clear links to underlying neurobiology, limiting their utility in identifying targeted treatments for individuals. Here, we aimed to investigate differences in functional brain network integrity between traditional diagnostic categories ...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101678
更新日期:2019-01-01 00:00:00
abstract::Etiological explanations of clinical anxiety can be advanced through understanding the neural mechanisms associated with anxiety in youth prior to the emergence of psychopathology. In this vein, the present study sought to investigate how trait anxiety is related to features of the structural connectome in early adole...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.09.012
更新日期:2017-09-21 00:00:00