Abstract:
Background:Behavioral inhibition (BI) is an early-appearing temperament trait and a robust predictor of social anxiety disorder (SAD). Both BI and anxiety may have distinct patterns of emotion processing marked by heightened neural responses to threat cues. BI and anxious children display similar frontolimbic patterns when completing an emotion-face attention bias task with supraliminal presentation. Anxious children also show a distinct neural response to the same task with subliminal face presentations, probing stimulus-driven attention networks. We do not have parallel data available for BI children, limiting our understanding of underlying affective mechanisms potentially linking early BI to the later emergence of anxiety. Method:We examined the neural response to subliminal threat presentation during an emotion-face masked dot-probe task in children oversampled for BI (N = 67; 30 BI, 9-12 yrs). Results:Non-BI children displayed greater activation versus BI children in several regions in response to threat faces versus neutral faces, including striatum, prefrontal and temporal lobes. When comparing congruent and incongruent trials, which require attention disengagement, BI children showed greater activation than non-BI children in the cerebellum, which is implicated in rapidly coordinating information processing, aversive conditioning, and learning the precise timing of anticipatory responses. Conclusions:Non-BI children may more readily engage rapid coordinated frontolimbic circuitry to salient stimuli, whereas BI children may preferentially engage subcortical circuitry, in response to limbic "alarms" triggered by subliminal threat cues. These data help reveal the extent to which temperamental risk shares similar neurocircuitry previously documented in anxious adolescents and young adults in response to masked threat.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Auday ES,Taber-Thomas BC,Pérez-Edgar KEdoi
10.1016/j.nicl.2018.04.003subject
Has Abstractpub_date
2018-04-12 00:00:00pages
202-212issn
2213-1582pii
S2213-1582(18)30111-6journal_volume
19pub_type
杂志文章abstract::Myotonic dystrophy type 1 (DM1) has a wide phenotypic spectrum and potentially may affect central nervous system with mild to severe involvement. Our aim was to investigate grey matter (GM) and white matter (WM) structural alterations in a sample of adult-onset DM1 patients and to evaluate relationship with clinical a...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.06.011
更新日期:2016-06-15 00:00:00
abstract::Unintentional and uncontrollable processing of threat has been suggested to contribute to the pathology of social anxiety disorder (SAD). The present study investigated the neural correlates of processing task-irrelevant, highly ecologically valid, disorder-related stimuli as a function of symptom severity in SAD. Twe...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2018.05.035
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2014.04.004
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abstract::It is difficult to distinguish schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar disorder with psychosis (BPP) as their clinical diagnoses rely on symptoms that overlap. In this paper, we investigate if there is biological evidence to support the symptom-based clinical categories by looking across the th...
journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.04.023
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2012.09.003
更新日期:2012-09-12 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2015.09.003
更新日期:2015-09-12 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2016.11.001
更新日期:2016-11-03 00:00:00
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pub_type: 已发布勘误
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更新日期:2020-01-01 00:00:00
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journal_title:NeuroImage. Clinical
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更新日期:2018-08-19 00:00:00