当前位置： SCI文献检索 > NeuroImage-Clinical期刊下所有文献 > Brain metabolic maps in Mild Cognitive Impairment predict heterogeneity of progression to dementia.

Brain metabolic maps in Mild Cognitive Impairment predict heterogeneity of progression to dementia.

Abstract：

:[(18)F]FDG-PET imaging has been recognized as a crucial diagnostic marker in Mild Cognitive Impairment (MCI), supporting the presence or the exclusion of Alzheimer's Disease (AD) pathology. A clinical heterogeneity, however, underlies MCI definition. In this study, we aimed to evaluate the predictive role of single-subject voxel-based maps of [(18)F]FDG distribution generated through statistical parametric mapping (SPM) in the progression to different dementia subtypes in a sample of 45 MCI. Their scans were compared to a large normal reference dataset developed and validated for comparison at single-subject level. Additionally, Aβ42 and Tau CSF values were available in 34 MCI subjects. Clinical follow-up (mean 28.5 ± 7.8 months) assessed subsequent progression to AD or non-AD dementias. The SPM analysis showed: 1) normal brain metabolism in 14 MCI cases, none of them progressing to dementia; 2) the typical temporo-parietal pattern suggestive for prodromal AD in 15 cases, 11 of them progressing to AD; 3) brain hypometabolism suggestive of frontotemporal lobar degeneration (FTLD) subtypes in 7 and dementia with Lewy bodies (DLB) in 2 subjects (all fulfilled FTLD or DLB clinical criteria at follow-up); and 4) 7 MCI cases showed a selective unilateral or bilateral temporo-medial hypometabolism without the typical AD pattern, and they all remained stable. In our sample, objective voxel-based analysis of [(18)F]FDG-PET scans showed high predictive prognostic value, by identifying either normal brain metabolism or hypometabolic patterns suggestive of different underlying pathologies, as confirmed by progression at follow-up. These data support the potential usefulness of this SPM [(18)F]FDG PET analysis in the early dementia diagnosis and for improving subject selection in clinical trials based on MCI definition.

journal_name

Neuroimage Clin

journal_title

NeuroImage. Clinical

authors

Cerami C,Della Rosa PA,Magnani G,Santangelo R,Marcone A,Cappa SF,Perani D

doi

10.1016/j.nicl.2014.12.004

subject

Has Abstract

pub_date

2014-12-05 00:00:00

pages

187-94

issn

2213-1582

pii

S2213-1582(14)00189-2

journal_volume

7

pub_type

杂志文章

相关文献

NeuroImage-Clinical文献大全
  • Cerebellar pathology in Friedreich's ataxia: atrophied dentate nuclei with normal iron content.

    abstract：BACKGROUND:In Friedreich's ataxia (FA) the genetically decreased expression of the mitochondrial protein frataxin leads to disturbance of the mitochondrial iron metabolism. Within the cerebellum the dentate nuclei (DN) are primarily affected. Histopathological studies show atrophy and accumulation of mitochondrial iron...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2014.08.018

    authors： Solbach K,Kraff O,Minnerop M,Beck A,Schöls L,Gizewski ER,Ladd ME,Timmann D

    更新日期：2014-08-23 00:00:00

  • Resting-state connectivity in neurodegenerative disorders: Is there potential for an imaging biomarker?

    abstract：:Biomarkers in whichever modality are tremendously important in diagnosing of disease, tracking disease progression and clinical trials. This applies in particular for disorders with a long disease course including pre-symptomatic stages, in which only subtle signs of clinical progression can be observed. Magnetic reso...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,评审

    doi：10.1016/j.nicl.2018.03.013

    authors： Hohenfeld C,Werner CJ,Reetz K

    更新日期：2018-03-16 00:00:00

  • Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms.

    abstract：:Approximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hyp...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102217

    authors： Bohorquez-Montoya L,España LY,Nader AM,Furger RE,Mayer AR,Meier TB

    更新日期：2020-01-01 00:00:00

  • Physical activity is associated with left corticospinal tract microstructure in bipolar depression.

    abstract：:Psychomotor retardation and reduced daily activities are core features of the depressive syndrome including bipolar disorder (BD). It was the aim of this study to investigate white matter microstructure of the motor system in BD during depression and its association with motor activity. We hypothesized reduced physica...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.09.033

    authors： Bracht T,Steinau S,Federspiel A,Schneider C,Wiest R,Walther S

    更新日期：2018-01-01 00:00:00

  • Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.

    abstract：:The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.07.008

    authors： Bagshaw AP,Hale JR,Campos BM,Rollings DT,Wilson RS,Alvim MKM,Coan AC,Cendes F

    更新日期：2017-07-12 00:00:00

  • Longitudinal changes in rich club organization and cognition in cerebral small vessel disease.

    abstract：:Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of cognitive impairment and dementia. There is increasing awareness that SVD exerts its clinical effects by disrupting white matter connections, predominantly disrupting connections between rich club nodes, a s...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102048

    authors： van Leijsen EMC,van Uden IWM,Bergkamp MI,van der Holst HM,Norris DG,Claassen JAHR,Kessels RPC,de Leeuw FE,Tuladhar AM

    更新日期：2019-01-01 00:00:00

  • Corrigendum to "Developmental synergy between thalamic structure and interhemispheric connectivity in the visual system of preterm infants" [NeuroImage: Clinical 8 (2015) 462-472].

    abstract：:[This corrects the article DOI: 10.1016/j.nicl.2015.05.014.]. ...

    journal_title：NeuroImage. Clinical

    pub_type： 已发布勘误

    doi：10.1016/j.nicl.2016.05.001

    authors： Ceschin R,Wisnowski JL,Erberich SG,Paquette LB,Nelson MD,Blüml S,Panigrahy A

    更新日期：2016-05-06 00:00:00

  • Spatiotemporal trajectories of quantitative magnetization transfer measurements in injured spinal cord using simplified acquisitions.

    abstract：PURPOSE:This study aims to systematically evaluate the accuracy and precision of pool size ratio (PSR) measurements from quantitative magnetization transfer (qMT) acquisitions using simplified models in the context of assessing injury-associated spatiotemporal changes in spinal cords of non-human primates. This study a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101921

    authors： Wang F,Wu TL,Li K,Chen LM,Gore JC

    更新日期：2019-01-01 00:00:00

  • Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.

    abstract：BACKGROUND CONTEXT:Spinal manipulation (SM) is a common treatment for neck and back pain, theorized to mechanically affect the spine leading to therapeutic mechanical changes. The link between specific mechanical effects and clinical improvement is not well supported. SM's therapeutic action may instead be partially me...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.nicl.2019.102042

    authors： Weber Ii KA,Wager TD,Mackey S,Elliott JM,Liu WC,Sparks CL

    更新日期：2019-01-01 00:00:00

  • Evidence of parietal hyperactivation in individuals with mild cognitive impairment who progressed to dementia: A longitudinal fMRI study.

    abstract：:Hyperactivation, which is defined as a higher level of activation in patients compared to cognitively unimpaired older adults (controls; CTL), might represent an early signature of Alzheimer's Disease (AD). The goal of this study was to assess the presence and location of hyperactivation in individuals with mild cogni...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101958

    authors： Corriveau-Lecavalier N,Mellah S,Clément F,Belleville S

    更新日期：2019-01-01 00:00:00

  • Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects.

    abstract：INTRODUCTION:Neuritic amyloid plaques and neurofibrillary tangles, the hallmark pathologic lesions of Alzheimer's disease, are thought to develop before the symptoms of brain failure are clinically detectable. Imaging methods capable of detecting the presence of neuritic amyloid plaques should improve a clinician's abi...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.10.007

    authors： Mountz JM,Laymon CM,Cohen AD,Zhang Z,Price JC,Boudhar S,McDade E,Aizenstein HJ,Klunk WE,Mathis CA

    更新日期：2015-10-14 00:00:00

  • Insight and emotion regulation in schizophrenia: A brain activation and functional connectivity study.

    abstract：BACKGROUND:Insight is impaired in the majority of schizophrenia patients. The exact neural correlates of impaired insight remain unclear. We assume that the ability to regulate emotions contributes to having good clinical insight, as patients should be able to regulate their emotional state in such a way that they can ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.09.009

    authors： Larabi DI,van der Meer L,Pijnenborg GHM,Ćurčić-Blake B,Aleman A

    更新日期：2018-01-01 00:00:00

  • Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women.

    abstract：AIM:Substance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domest...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101973

    authors： Poppa T,Droutman V,Amaro H,Black D,Arnaudova I,Monterosso J

    更新日期：2019-01-01 00:00:00

  • Regional cortical thickness changes accompanying generalized tonic-clonic seizures.

    abstract：Objective:Generalized tonic-clonic seizures are accompanied by cardiovascular and respiratory sequelae that threaten survival. The frequency of these seizures is a major risk factor for sudden unexpected death in epilepsy (SUDEP), a leading cause of untimely death in epilepsy. The circumstances accompanying such fatal ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.07.015

    authors： Ogren JA,Tripathi R,Macey PM,Kumar R,Stern JM,Eliashiv DS,Allen LA,Diehl B,Engel J Jr,Rani MRS,Lhatoo SD,Harper RM

    更新日期：2018-07-18 00:00:00

  • Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia.

    abstract：:Neuropsychological assessment, brain imaging and computational modelling have augmented our understanding of the multifaceted functional deficits in people with language disorders after stroke. Despite the volume of research using each technique, no studies have attempted to assimilate all three approaches in order to...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2018.03.031

    authors： Tochadse M,Halai AD,Lambon Ralph MA,Abel S

    更新日期：2018-03-27 00:00:00

  • Injury to white matter tracts in relapsing-remitting multiple sclerosis: A possible therapeutic window within the first 5 years from onset using diffusion-tensor imaging tract-based spatial statistics.

    abstract：:DTI studies in multiple sclerosis (MS) reveal white matter (WM) injury that occurs with disease progression. In the present study we aimed to elucidate the relationship of microstructural WM damage in patients with varying periods of disease duration. DTI scans were acquired from 90 MS patients and 25 healthy controls...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.04.020

    authors： Asaf A,Evan S,Anat A

    更新日期：2015-04-30 00:00:00

  • An affected core drives network integration deficits of the structural connectome in 22q11.2 deletion syndrome.

    abstract：:Chromosome 22q11.2 deletion syndrome (22q11DS) is a genetic disease known to lead to cerebral structural alterations, which we study using the framework of the macroscopic white-matter connectome. We create weighted connectomes of 44 patients with 22q11DS and 44 healthy controls using diffusion tensor magnetic resonan...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2015.11.017

    authors： Váša F,Griffa A,Scariati E,Schaer M,Urben S,Eliez S,Hagmann P

    更新日期：2015-11-26 00:00:00

  • Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1.

    abstract：:Myotonic dystrophy type 1 (DM1) has a wide phenotypic spectrum and potentially may affect central nervous system with mild to severe involvement. Our aim was to investigate grey matter (GM) and white matter (WM) structural alterations in a sample of adult-onset DM1 patients and to evaluate relationship with clinical a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.06.011

    authors： Baldanzi S,Cecchi P,Fabbri S,Pesaresi I,Simoncini C,Angelini C,Bonuccelli U,Cosottini M,Siciliano G

    更新日期：2016-06-15 00:00:00

  • Structural brain differences in pre-adolescents who persist in and recover from stuttering.

    abstract：BACKGROUND:Stuttering is a complex speech fluency disorder occurring in childhood. In young children, stuttering has been associated with speech-related auditory and motor areas of the brain. During transition into adolescence, the majority of children who stutter (75-80%) will experience remission of their symptoms. T...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102334

    authors： Koenraads SPC,van der Schroeff MP,van Ingen G,Lamballais S,Tiemeier H,Baatenburg de Jong RJ,White T,Franken MC,Muetzel RL

    更新日期：2020-01-01 00:00:00

  • DTI detects water diffusion abnormalities in the thalamus that correlate with an extremity pain episode in a patient with multiple sclerosis.

    abstract：BACKGROUND:Various types of multiple sclerosis (MS) related pain have been discussed. One concept is that deafferentation secondary to lesions in the spino-thalamo-cortical network can cause central pain. However, this hypothesis is somehow limited by a lack of a robust association between pain episodes and sites of le...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2013.01.008

    authors： Deppe M,Müller D,Kugel H,Ruck T,Wiendl H,Meuth SG

    更新日期：2013-01-28 00:00:00

  • Brain connectivity tracks effects of chemotherapy separately from behavioral measures.

    abstract：:Several studies in cancer research have suggested that cognitive dysfunction following chemotherapy, referred to in lay terms as "chemobrain", is a serious problem. At present, the changes in integrative brain function that underlie such dysfunction remain poorly understood. Recent developments in neuroimaging suggest...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101654

    authors： Kardan O,Reuter-Lorenz PA,Peltier S,Churchill NW,Misic B,Askren MK,Jung MS,Cimprich B,Berman MG

    更新日期：2019-01-01 00:00:00

  • Simultaneous investigation of microvasculature and parenchyma in cerebral small vessel disease using intravoxel incoherent motion imaging.

    abstract：INTRODUCTION:Cerebral small vessel disease (cSVD) is associated with microvascular and parenchymal alterations. Intravoxel incoherent motion (IVIM) MRI has been proposed to simultaneously measure both the microvascular perfusion and parenchymal diffusivity. This study aimed to evaluate the application of IVIM in cSVD t...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.01.017

    authors： Wong SM,Zhang CE,van Bussel FC,Staals J,Jeukens CR,Hofman PA,van Oostenbrugge RJ,Backes WH,Jansen JF

    更新日期：2017-01-17 00:00:00

  • Functional brain connectome in posterior cortical atrophy.

    abstract：:This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.102100

    authors： Migliaccio R,Agosta F,Basaia S,Cividini C,Habert MO,Kas A,Montembeault M,Filippi M

    更新日期：2020-01-01 00:00:00

  • Linked anatomical and functional brain alterations in children with attention-deficit/hyperactivity disorder.

    abstract：OBJECTIVES:Neuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data. ...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2019.101851

    authors： Wu ZM,Llera A,Hoogman M,Cao QJ,Zwiers MP,Bralten J,An L,Sun L,Yang L,Yang BR,Zang YF,Franke B,Beckmann CF,Mennes M,Wang YF

    更新日期：2019-01-01 00:00:00

  • Ketamine normalizes brain activity during emotionally valenced attentional processing in depression.

    abstract：Background:An urgent need exists for faster-acting pharmacological treatments in major depressive disorder (MDD). The glutamatergic modulator ketamine has been shown to have rapid antidepressant effects, but much remains unknown about its mechanism of action. Functional MRI (fMRI) can be used to investigate how ketamin...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.nicl.2018.07.006

    authors： Reed JL,Nugent AC,Furey ML,Szczepanik JE,Evans JW,Zarate CA Jr

    更新日期：2018-07-05 00:00:00

  • Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment.

    abstract：BACKGROUND:Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent a possible source of impaired neurocognitive functioning and were analyzed in these patients. METHODS:Eig...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102287

    authors： Kocher M,Jockwitz C,Caspers S,Schreiber J,Farrher E,Stoffels G,Filss C,Lohmann P,Tscherpel C,Ruge MI,Fink GR,Shah NJ,Galldiks N,Langen KJ

    更新日期：2020-01-01 00:00:00

  • Subacute functional connectivity correlates with cognitive recovery six months after stroke.

    abstract：BACKGROUND AND PURPOSE:Cognitive impairment is a common consequence of stroke, and the rewiring of the surviving brain circuits might contribute to cognitive recovery. Studies investigating how the functional connectivity of networks change across time and whether their remapping relates to cognitive recovery in stroke...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102538

    authors： Vicentini JE,Weiler M,Casseb RF,Almeida SR,Valler L,de Campos BM,Li LM

    更新日期：2020-12-17 00:00:00

  • Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy.

    abstract：:The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events a...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2016.05.010

    authors： Wirsich J,Perry A,Ridley B,Proix T,Golos M,Bénar C,Ranjeva JP,Bartolomei F,Breakspear M,Jirsa V,Guye M

    更新日期：2016-05-19 00:00:00

  • Application of calibrated fMRI in Alzheimer's disease.

    abstract：:Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast (BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on cerebrovascular reactivity (CVR), resting blood flow (CBF), oxygen extraction fraction (OEF), and resting oxidative metabolism (CMRO2). Vascul...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2017.05.009

    authors： Lajoie I,Nugent S,Debacker C,Dyson K,Tancredi FB,Badhwar A,Belleville S,Deschaintre Y,Bellec P,Doyon J,Bocti C,Gauthier S,Arnold D,Kergoat MJ,Chertkow H,Monchi O,Hoge RD

    更新日期：2017-05-16 00:00:00

  • Structural brain alterations and their association with cognitive function and symptoms in Attention-deficit/Hyperactivity Disorder families.

    abstract：:Gray matter disruptions have been found consistently in Attention-deficit/Hyperactivity Disorder (ADHD). The organization of these alterations into brain structural networks remains largely unexplored. We investigated 508 participants (281 males) with ADHD (N = 210), their unaffected siblings (N = 108), individuals wi...

    journal_title：NeuroImage. Clinical

    pub_type： 杂志文章

    doi：10.1016/j.nicl.2020.102273

    authors： Jiang W,Duan K,Rootes-Murdy K,Hoekstra PJ,Hartman CA,Oosterlaan J,Heslenfeld D,Franke B,Buitelaar J,Arias-Vasquez A,Liu J,Turner JA

    更新日期：2020-01-01 00:00:00