Abstract:
INTRODUCTION:Neuritic amyloid plaques and neurofibrillary tangles, the hallmark pathologic lesions of Alzheimer's disease, are thought to develop before the symptoms of brain failure are clinically detectable. Imaging methods capable of detecting the presence of neuritic amyloid plaques should improve a clinician's ability to identify Alzheimer's disease during the earliest symptomatic phase and to identify at-risk individuals presymptomatically. Currently the best studied amyloid imaging ligand is [(11)C]Pittsburgh Compound B ([(11)C]PiB). However, the 20-minute half-life of this radiotracer limits its use. This study is designed to evaluate the performance characteristics of [(18)F]flutemetamol and to independently compare results to [(11)C]PiB in the same subjects. METHODS:Twenty-three subjects, 15 cognitively normal (NL) and 8 with a clinical diagnosis of Alzheimer's Dementia (AD), underwent [(11)C]PiB and [(18)F]flutemetamol PET scans within 28 days of study enrollment. We studied both normal and AD subjects to assess the uptake characteristics across a range of amyloid positivity. Blinded visual reads were conducted by five raters. Correlation analyses were performed between cortical SUVR for the two tracers and also between rater scores and SUVR for each tracer. Overall reader accuracy for classifying scans as amyloid positive or negative was determined for each tracer using SUVR classification as the standard. RESULTS:The linear correlation coefficient between global cortical SUVR for the two tracers was R(2) = 0.85, indicating that both tracers have similar retention characteristics. The two tracers were well correlated for rater-determined AD-like positivity (Cohen κ = 0.82). Averaged visual ratings and global cortical SUVR disagreed on their classification in 2/23 [(11)C]PiB scans and 4/23 [(18)F]flutemetamol scans. CONCLUSIONS:[(11)C]PiB and [(18)F]flutemetamol have similar retention characteristics across a range of amyloid negative to positive subjects. Both tracers performed similarly when a standardized visual read technique was used to classify scans as amyloid-positive or amyloid-negative and correlated well with SUVR classifications. However, care in visual interpretation of amyloid positive versus amyloid negative regions should be taken, particularly in the case of [(18)F]flutemetamol when considering cortical vs. white-matter retention.
journal_name
Neuroimage Clinjournal_title
NeuroImage. Clinicalauthors
Mountz JM,Laymon CM,Cohen AD,Zhang Z,Price JC,Boudhar S,McDade E,Aizenstein HJ,Klunk WE,Mathis CAdoi
10.1016/j.nicl.2015.10.007subject
Has Abstractpub_date
2015-10-14 00:00:00pages
592-8issn
2213-1582pii
S2213-1582(15)30007-3journal_volume
9pub_type
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2017.07.008
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journal_title:NeuroImage. Clinical
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2014.04.004
更新日期:2014-04-13 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.01.001
更新日期:2018-01-06 00:00:00
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doi:10.1016/j.nicl.2018.02.036
更新日期:2018-03-03 00:00:00
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2018.04.014
更新日期:2018-04-21 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.nicl.2018.05.018
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doi:10.1016/j.nicl.2018.10.010
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2020.102287
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journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2013.07.011
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abstract::One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsy...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章
doi:10.1016/j.nicl.2019.101721
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abstract:BACKGROUND:Multiple pathway models of ADHD suggest that multiple, separable biological pathways may lead to symptoms of the disorder. If this is the case, it should be possible to identify subgroups of children with ADHD based on distinct patterns of brain activity. Previous studies have used latent class analysis (LCA...
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doi:10.1016/j.nicl.2018.11.011
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abstract:Background:An urgent need exists for faster-acting pharmacological treatments in major depressive disorder (MDD). The glutamatergic modulator ketamine has been shown to have rapid antidepressant effects, but much remains unknown about its mechanism of action. Functional MRI (fMRI) can be used to investigate how ketamin...
journal_title:NeuroImage. Clinical
pub_type: 杂志文章,随机对照试验
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更新日期:2018-07-05 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:NeuroImage. Clinical
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doi:10.1016/j.nicl.2020.102513
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journal_title:NeuroImage. Clinical
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