Abstract：
BACKGROUND:Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Due to increased CAD risk factors in Saudi Arabia, research on more feasible and predictive biomarkers is needed. We aimed to evaluate glycated hemoglobin (HbA1c) as a predictor of CAD in low-risk profile non-diabetic patients living in the Al Qassim region of Saudi Arabia. METHODS:Thirty-eight patients with no history of CAD were enrolled in this cross-sectional study. They provided demographic data, and their HbA1c estimation followed the National Glycohemoglobin Standardization Program parameters. All patients underwent coronary computed tomography angiography (CCTA) for evaluation of chest pain. The extent of coronary artery stenosis (CAS) was quantified as percentage for each patient based on plaques detected in CCTA. RESULTS:Mean blood pressure of the patients was (91.2 ± 11.9 mmHg), BMI (28.3 ± 5.8 kg/m2), serum cholesterol level (174 ± 33.1 mg/dl), and HbA1c levels (mean 5.7 ± 0.45, median 5.7 and range 4.7-6.4%). Eighteen patients showed no CAS (47.4%), 12 showed minimal stenosis (31.6%), 3 showed mild stenosis (7.9%), 3 showed moderate stenosis (7.9%) and 2 showed severe stenosis (5.3%). A moderate correlation was detected between HbA1c and CAS percentages (r = 0.47, p < 0.05) as well as between HbA1c and the number of affected coronary vessels (r = 0.53, p < 0.001). CONCLUSION:Glycated hemoglobin can be used as a predictive biomarker for CAD in non-diabetic low-risk patients.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Ewid M,Sherif H,Billah SMB,Saquib N,AlEnazy W,Ragab O,Enabi S,Rajab T,Awad Z,Abazid Rdoi
10.1186/s12872-019-01302-5subject
Has Abstractpub_date
2019-12-21 00:00:00pages
309issue
1issn
1471-2261pii
10.1186/s12872-019-01302-5journal_volume
19pub_type
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