Abstract：
BACKGROUND:Although drug-eluting stents have dramatically reduced the rates of restenosis and target lesion revascularization, they are associated with stent thrombosis (ST), a catastrophic event likely due to delayed endothelialization and chronic inflammation caused by the polymer and the metal scaffolds. To increase the safety and efficacy of stents, polymer-free dual drug-eluting stents (DDES) have been developed. METHODS:A total 160 stents (Bare-metal stents (BMS), polymer-free probucol stents (PrES), sirolimus-eluting stents (SES) and DDES) were randomly implanted in the coronary arteries of 80 pigs. 14, 28, 90 and 191 days after implantation, QCA and OCT evaluations were performed in 20 pigs respectively, and the arteries were harvested for scanning electron microscope (SEM), histomorphology, histopathology analyses and for the relative expression of CD31, CD34 and CD133 on mRNA and protein levels. RESULTS:At the 14-day time point, there were significant differences in the strut rate coverage (p = 0.011), with greater coverage in the PrES than in the SES group (53.2%vs. 20.3%, p = 0.002). As well, there were no significant differences in the expression of CD31, CD34 and CD133 between groups in mRNA and protein level. CONCLUSIONS:DDES were as safe as BMS and SES, but they did not further improve the endothelialization of the stented coronary arteries in the porcine model.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Zhang B,Zheng B,Wang X,Shi Q,Jia J,Huo Y,Pan C,Han J,Chen Mdoi
10.1186/s12872-017-0654-7subject
Has Abstractpub_date
2017-08-15 00:00:00pages
222issue
1issn
1471-2261pii
10.1186/s12872-017-0654-7journal_volume
17pub_type
杂志文章abstract：BACKGROUND:While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear. METHODS:Forty-eight patients with unstabl...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0702-3
更新日期：2017-10-18 00:00:00
abstract：BACKGROUND:Heart failure (HF) is one of the most debilitating chronic illnesses. The prevalence is expected to increase due to aging population. The current study aimed to examine the management of heart failure with preserved ejection fraction (HFpEF) including drug use pattern, direct medical cost and humanistic outc...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0002-8
更新日期：2015-02-25 00:00:00
abstract：BACKGROUND:Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogen...
journal_title：BMC cardiovascular disorders
pub_type： 临床试验,杂志文章
doi：10.1186/1471-2261-12-11
更新日期：2012-02-27 00:00:00
abstract：BACKGROUND:Tobacco smoke is one of the most significant risk factors for cardiovascular diseases and damages in the myocardial tissue directly. Cardiac magnetic resonance (CMR) has been used and is a promising tool to evaluate morphometry and cardiac function in humans. The objective of this study was to evaluate assoc...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01372-w
更新日期：2020-02-06 00:00:00
abstract：BACKGROUND:Infective endocarditis is an uncommon but life-threatening infectious disease. To our knowledge, current investigations of the characteristics of infective endocarditis in our region are scarce. In this study, we aimed to investigate the changes in the epidemiology and clinical features of infective endocard...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0548-8
更新日期：2017-05-08 00:00:00
abstract：BACKGROUND:We evaluated the associations among angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and post-myocardial infarction (MI) left ventricular dysfunction and acute heart failure (AHF) early after presentation with MI with ST-segment elevation (STEMI). METHODS:A total ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-10-60
更新日期：2010-12-17 00:00:00
abstract：BACKGROUND:To investigate the impact of uric acid (UA) levels on cardiovascular disease and mortality at a population level. METHODS:Prospective analysis of baseline serum UA measurement and 15 year follow-up data from the Busselton Health Survey (n = 4,173), stratified by existence or absence of baseline cardiovascul...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0421-1
更新日期：2016-12-15 00:00:00
abstract：BACKGROUND:Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is increasingly used to assess myocardial involvement in patients with Fabry disease, an X linked lipid storage disorder. However, it is often proposed as an optional tool. A different cardiomyopathic disease progression b...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-14-86
更新日期：2014-07-16 00:00:00
abstract：BACKGROUND:Intervention of diabetes care education with regular laboratory check-up in outpatient visits showed long-term benefits to reduce the risk of macrovascular complications among people with type 2 diabetes. However, research on the level of a priori health knowledge to the prevention of diabetic complications ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0568-4
更新日期：2017-05-22 00:00:00
abstract：BACKGROUND:The incidence and mortality of cardiovascular diseases (CVDs) in low and middle income countries (LMICs) have been increasing, while access to CVDs medicines is suboptimal. We assessed selection of essential medicines for the prevention and treatment of CVDs on national essential medicines lists (NEMLs) of L...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0858-5
更新日期：2018-06-25 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate whether screening for abdominal aortic aneurysm (AAA) has led to a decrease in ruptured AAA (rAAA) incidence. METHOD:The Malmö population was evaluated regarding the incidence of rAAA and elective AAA surgery 4 years before and after start of AAA-screening in 2010. Data...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0215-5
更新日期：2016-02-17 00:00:00
abstract：BACKGROUND:A number of registry studies have reported suboptimal adherence to guidelines for cardiovascular prevention during the first year after acute myocardial infarction (AMI). However, only a few studies have addressed long-term secondary prevention after AMI. This study evaluates prevention guideline adherence a...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0400-6
更新日期：2016-11-17 00:00:00
abstract：BACKGROUND:The direct oral anticoagulants (DOACs) reduce the risk of stroke in moderate to high-risk patients with non-valvular atrial fibrillation (AF). Yet, concerns remain regarding its routine use in real world practice. We sought to describe adherence patterns and the association between adherence and outcomes to ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0671-6
更新日期：2017-09-02 00:00:00
abstract：BACKGROUND:Neointimal formation in atherosclerosis has been subject for intense research. However, good animal models mimicking asymmetrical lesion formation in human subjects have been difficult to establish. The aim of this study was to develop a model which would lead to the formation of eccentric lesions under macr...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-12-91
更新日期：2012-10-17 00:00:00
abstract：BACKGROUND:Premature infants may present with damage to the autonomic nervous system (ANS), which may be related to poorer neurological development. Among the techniques used to evaluate the ANS, heart rate variability (HRV) emerged as a simple, non-invasive, and easy to apply tool. The aim of the present study was to ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1166-4
更新日期：2019-08-16 00:00:00
abstract：BACKGROUND:Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates the production of cellular oxidants and it may also promote vascu...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2261-12-75
更新日期：2012-09-17 00:00:00
abstract：BACKGROUND:Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus,...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0801-9
更新日期：2018-04-16 00:00:00
abstract：BACKGROUND:Provisional 1-stent technique is currently regarded as the default approach for the majority of bifurcation lesions. Nonetheless, 2-stent techniques may be required for complex bifurcations with high compromise risk or fatal consequences of side branch (SB) occlusion. Limitations exist in current approaches,...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01605-y
更新日期：2020-07-07 00:00:00
abstract：BACKGROUND:The health-related quality of life (HRQOL) of hypertensives may be influenced by blood pressure, adverse effects of drugs used to treat hypertension, or other factors, such as the labelling effect, or beliefs and attitudes about illness and treatment. There is paucity of information on the determinants of HR...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-9-25
更新日期：2009-06-17 00:00:00
abstract：BACKGROUND:Periostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin in left ventricular remodeling of streptozototin (STZ)-induced diabetic rats. The aim of the present study was to observe the expression of periostin...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0084-3
更新日期：2015-08-18 00:00:00
abstract：BACKGROUND:Disease-management programmes including patient education have promoted improvement in outcome for patients with heart failure. However, there is sparse evidence concerning which component is essential for success, and very little is known regarding the validity of methods or material used for the education....
journal_title：BMC cardiovascular disorders
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2261-6-30
更新日期：2006-06-24 00:00:00
abstract：BACKGROUND:Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimetazidine could favorably affect this process also needs to be determined. The aim of the study was to ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0399-8
更新日期：2016-11-17 00:00:00
abstract：BACKGROUND:Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary ar...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0320-5
更新日期：2016-07-08 00:00:00
abstract：BACKGROUND:The relationship between vitamin D levels and peripheral arterial disease (PAD) remains unclear. We assessed the association of serum 25-hydroxyvitamin D (25(OH)D) levels with the prevalence of PAD in patients with type 2 diabetes mellitus(T2DM). METHODS:A total of 1018 T2DM patients participated in this cr...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1125-0
更新日期：2019-06-17 00:00:00
abstract：BACKGROUND:There have been suggestions of an association between Chlamydia pneumoniae, chlamydial heat shock protein (Ch-hsp) 60 and human heat shock protein (h-hsp) 60 infection sero-status and development of secondary cardiovascular events. Patients with diabetes might be at higher risk since they are prone to infect...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-6-17
更新日期：2006-04-12 00:00:00
abstract：BACKGROUND:Studies from Saudi Arabia have reported a continued increase in the prevalence of cardiovascular diseases and their associated risk factors. The objective of this study was to measure the gender differences in the cardiovascular disease (CVD) risk based on Framingham risk scores (FRS) and to explore the asso...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1048-9
更新日期：2019-04-08 00:00:00
abstract：BACKGROUND:Despite the potentially life-saving benefits of the implantable cardioverter-defibrillator (ICD), a significant group of patients experiences emotional distress after ICD implantation. Different psychosocial interventions have been employed to improve this condition, but previous reviews have suggested that ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,评审
doi：10.1186/1471-2261-9-56
更新日期：2009-12-29 00:00:00
abstract：OBJECTIVE:To develop and recalibrate an Australian 5-year cardiovascular disease (CVD) mortality risk score to produce contemporary predictions of risk. METHODS:Data were pooled from six Australian cohort studies (n = 54,829), with baseline data collected between 1989 and 2003. Participants included were aged 40-74 ye...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/s12872-016-0462-5
更新日期：2017-01-06 00:00:00
abstract：BACKGROUND:Cardiac fibrosis play a key role in the atrial fibrillation pathogenesis but the underlying potential molecular mechanism is still understood. However, potential mechanisms for miR-21 upregulation and its role in cardiac fibrosis remain unclear. The controls cell proliferation and processes fundamental to di...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0520-7
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:Serum paraoxonase 1 (PON1), an enzyme associated with high - density lipoproteins (HDL) particles, inhibits the oxidation of serum lipoproteins and cell membranes. PON1 activity is lower in patients with atherosclerosis and in inflammatory diseases. The systemic inflammatory response provoked during cardiopu...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0528-z
更新日期：2017-04-04 00:00:00
