Abstract:
BACKGROUND:Periostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin in left ventricular remodeling of streptozototin (STZ)-induced diabetic rats. The aim of the present study was to observe the expression of periostin in Wistar rat's myocardium of diabetic cardiomyopathy (DCM) and the effect of valsartan on it. METHODS:Immunohistochemistry, real-time polymerase chain reaction, and Western blot analysis were used to determine the degree of expression and location of periostin, transforming growth factor (TGF)-β1, TGF-β1 type II receptor (TGF-β1 R II), and Type I and III collagens in the myocardium of STZ-induced diabetic rats. RESULTS:Periostin, TGF-β1, TGF-β1 R II, and Type I and III collagens were significantly increased in the myocardium of diabetic rats compared with control group on both messenger ribonucleic acid and protein levels. In addition, diabetic rats treated with valsartan could have reduced expression of periostin and improved cardiac remodeling of DCM. CONCLUSIONS:Periostin may play a crucial role in cardiac remodeling and myocardial interstitial fibrosis process of DCM and it could be one of the important mechanisms for valsartan to improve the ventricular remodeling of DCM.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Guan J,Liu WQ,Xing MQ,Shi Y,Tan XY,Jiang CQ,Dai HYdoi
10.1186/s12872-015-0084-3subject
Has Abstractpub_date
2015-08-18 00:00:00pages
90issn
1471-2261pii
10.1186/s12872-015-0084-3journal_volume
15pub_type
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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