Abstract:
BACKGROUND:The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardiovascular disease remains under-researched. This study evaluated the effects of B2M on CAD without renal dysfunction. METHODS:One thousand seven hundred sixty-two subjects (403 non-CAD subjects and 1,359 CAD subjects) were investigated. Fasting samples were collected to determine B2M level. The Gensini and SYNTAX scores were used to assess the severity of CAD. RESULTS:CAD subjects were significantly higher in serum B2M level comparing with non-CAD subjects (1.25 ± 0.46 vs 1.14 ± 0.28 mg/L, p < 0.001). Serum B2M level was a risk factor of CAD after adjusting potential confounders (Odds Ratio (OR) = 2.363, 95% confidence interval (CI): 1.467-3.906, p = 0.001). Receiver operating characteristics (ROC) showed B2M level moderately predicted diagnosis of CAD (the area under the ROC curve (AUC) = 0.608, 95% CI: 0.577-0.639, p < 0.001). Furthermore, serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of disease vessels (NDV ≥ 2). CONCLUSIONS:The significant association between serum B2M and CAD suggests that B2M could be a biomarker for CAD.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
You L,Xie R,Hu H,Gu G,Zheng H,Zhang J,Yang X,He X,Cui Wdoi
10.1186/s12872-017-0502-9subject
Has Abstractpub_date
2017-03-01 00:00:00pages
71issue
1issn
1471-2261pii
10.1186/s12872-017-0502-9journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Several studies on the growth rates of abdominal aortic aneurysm (AAA) in Chinese population have been conducted; however, this issue remains unclear. The aim of this study is to systematically review published data of the AAA growth rates among people in China. METHODS:We conducted a comprehensive search o...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1160-x
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:The optimal cutoff of the waist-to-hip ratio (WHR) among Han adults in Xinjiang, which is located in the center of Asia, is unknown. We aimed to examine the relationship between different WHRs and cardiovascular risk factors among Han adults in Xinjiang, and determine the optimal cutoff of the WHR. METHODS:...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-93
更新日期:2014-07-29 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0807-3
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-182
更新日期:2014-12-11 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2261-12-30
更新日期:2012-04-25 00:00:00
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pub_type: 杂志文章
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0618-y
更新日期:2017-07-03 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1186/s12872-017-0553-y
更新日期:2017-05-10 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-13-40
更新日期:2013-06-10 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12872-018-0864-7
更新日期:2018-06-28 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
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更新日期:2018-08-20 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 已发布勘误
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更新日期:2019-10-18 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-017-0701-4
更新日期:2017-10-18 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12872-019-1201-5
更新日期:2019-10-26 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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更新日期:2012-11-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2010-11-10 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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更新日期:2012-03-22 00:00:00
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更新日期:2016-11-17 00:00:00