当前位置： SCI文献检索 > BMC Cardiovascular Disorders期刊下所有文献 > Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.

Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.

Abstract：

BACKGROUND:Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the effects of a novel cardiac myosin activator, Omecamtiv-mecarbil (OM), in rats with chronic severe AR. METHODS:AR was created by retrograde puncture of the aortic valve leaflets in 20 adults Wistar rats. 12 animals survived the acute AR phase and were randomized 2 months thereafter into OM (n = 7) or placebo groups (n = 5). Two rats underwent a sham operation and served as controls. Equal volumes of OM or placebo (NaCl 0.9%) were perfused in the femoral vein by continuous infusion (1.2 mg/kg/hour) during 30 min. Doppler-echocardiography was performed before and at the end of the infusion periods. RESULTS:OM increased indices of global cardiac function (cardiac output, stroke volume), and increased systolic performance (fractional shortening, ejection fraction, left ventricular end systolic diameter) (all p < 0.05). These effects concurred with decreases in indices of LV preload (left atrial size, left ventricular end diastolic diameter) as well in the aortic pre-ejection period / left ventricular ejection time ratio (all p < 0.05). The severity score of the regurgitant AR jet did not change. Placebo infusion did not affect these parameters. CONCLUSION:The cardiac myosin activator OM exerts favorable hemodynamic effects in rats with experimental chronic AR.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

El-Oumeiri B,Mc Entee K,Annoni F,Herpain A,Vanden Eynden F,Jespers P,Van Nooten G,van de Borne P

doi

10.1186/s12872-018-0831-3

subject

Has Abstract

pub_date

2018-05-21 00:00:00

pages

99

issue

1

issn

1471-2261

pii

10.1186/s12872-018-0831-3

journal_volume

18

pub_type

杂志文章

相关文献

BMC Cardiovascular Disorders文献大全
  • Quality of life after aortic valve repair is similar to Ross patients and superior to mechanical valve replacement: a cross-sectional study.

    abstract：BACKGROUND:In patients after aortic valve surgery, the quality of life is hypothesized to be influenced by the type of the valve procedure. A cross-sectional study on the postoperative quality of life was carried out in patients after aortic valve-sparing surgery (with regards to the age of the patient), Ross procedure...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-016-0236-0

    authors： Zacek P,Holubec T,Vobornik M,Dominik J,Takkenberg J,Harrer J,Vojacek J

    更新日期：2016-04-02 00:00:00

  • Ultrasound-targeted microbubble destruction promotes myocardial angiogenesis and functional improvements in rat model of diabetic cardiomyopathy.

    abstract：BACKGROUND:Microvascular insufficiency plays an important role in the development of diabetic cardiomyopathy (DCM), therapeutic angiogenesis has been mainly used for the treatment of ischemic diseases. This study sought to verify the preclinical performance of SonoVue microbubbles (MB) combined ultrasound (US) treatmen...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01815-4

    authors： Zhang X,Tian X,Li P,Zhu H,Zhou N,Fang Z,Yang Y,Jing Y,Yuan J

    更新日期：2021-01-07 00:00:00

  • Circulating angiopoietins-1 and -2, angiopoietin receptor Tie-2 and vascular endothelial growth factor-A as biomarkers of acute myocardial infarction: a prospective nested case-control study.

    abstract：BACKGROUND:Angiogenesis is up-regulated in myocardial ischemia. However, limited data exist assessing the value of circulating angiogenic biomarkers in predicting future incidence of acute myocardial infarction (AMI). Our aim was to examine the association between circulating levels of markers of angiogenesis with risk...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-11-31

    authors： Iribarren C,Phelps BH,Darbinian JA,McCluskey ER,Quesenberry CP,Hytopoulos E,Vogelman JH,Orentreich N

    更新日期：2011-06-14 00:00:00

  • The role of Asprosin in patients with dilated cardiomyopathy.

    abstract：BACKGROUND:Asprosin is a novel fasting glucogenic adipokine discovered in 2016. Asprosin induces rapid glucose releases from the liver. However, its molecular mechanisms and function are still unclear. Adaptation of energy substrates from fatty acid to glucose is recently considered a novel therapeutic target in heart ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01680-1

    authors： Wen MS,Wang CY,Yeh JK,Chen CC,Tsai ML,Ho MY,Hung KC,Hsieh IC

    更新日期：2020-09-07 00:00:00

  • Comparison of bioresorbable vs durable polymer drug-eluting stents in unprotected left main (from the RAIN-CARDIOGROUP VII Study).

    abstract：BACKGROUND:There are limited data regarding the impact of bioresorbable polymer drug eluting stent (BP-DES) compared to durable polymer drug eluting stent (DP-DES) in patients treated with percutaneous coronary intervention using ultrathin stents in left main or bifurcations. METHODS:In the RAIN registry (ClinicalTria...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12872-020-01420-5

    authors： Iannaccone M,Barbero U,De Benedictis M,Imori Y,Quadri G,Trabattoni D,Ryan N,Venuti G,Montabone A,Wojakowski W,Rognoni A,Helft G,Parma R,De Luca L,Autelli M,Boccuzzi G,Mattesini A,Templin C,Cerrato E,Wańha W,Smolka

    更新日期：2020-05-15 00:00:00

  • A 10- and 15-year performance analysis of ESC/EAS and ACC/AHA cardiovascular risk scores in a Southern European cohort.

    abstract：BACKGROUND:A key strategy for the primary prevention of cardiovascular disease (CVD) is the use of risk prediction algorithms. We aimed to investigate the predictive ability of SCORE (Systematic COronary Risk Estimation) and PCE (Pooled Cohort Equations) systems for atherosclerotic CVD (ASCVD) risk in Portugal, a low C...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01574-2

    authors： Santos-Ferreira C,Baptista R,Oliveira-Santos M,Moura JP,Gonçalves L

    更新日期：2020-06-19 00:00:00

  • Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up.

    abstract：BACKGROUND:Left ventricle mass (LVM) can be influenced by various conditions including hypertension and/or inherent cardiomyopathies. Dysglycemia is also thought to exert an anabolic effect on heart tissue by hyperinsulinemia and thereby promoting increased LVM. The primary aim of this study was to assess the influence...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-019-1084-5

    authors： Pararajasingam G,Løgstrup BB,Høfsten DE,Christophersen TB,Auscher S,Hangaard J,Egstrup K

    更新日期：2019-05-02 00:00:00

  • Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation.

    abstract：BACKGROUND:Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron load on proteolysis ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-14-49

    authors： Chen MP,Li SN,Lam WW,Ho YC,Ha SY,Chan GC,Cheung YF

    更新日期：2014-04-12 00:00:00

  • The characteristics and risk factors of in-stent restenosis in patients with percutaneous coronary intervention: what can we do.

    abstract：BACKGROUND:Percutaneous coronary intervention (PCI) is a common treatment for patients with coronary heart disease, and intra-stent restenosis (ISR) is a serious complication after PCI. It's necessary to identify the potential risk factors to provide evidence for the prevention of ISR. METHODS:The patients who underwe...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01798-2

    authors： Wang P,Qiao H,Wang R,Hou R,Guo J

    更新日期：2020-12-04 00:00:00

  • Long-term treatment effect and adverse events of a modified jailed-balloon technique for side branch protection in patients with coronary bifurcation lesions.

    abstract：BACKGROUND:Percutaneous coronary interventions (PCI) of bifurcation lesions is technically challenging and associated with lower success rates and higher frequency of adverse outcomes. In the present study, we aimed to evaluate the immediate and long-term treatment effect and adverse events of a new modified jailed-bal...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-018-0995-x

    authors： Zhang W,Ji F,Yu X,Wang X

    更新日期：2019-01-10 00:00:00

  • Omentin-1 is associated with atrial fibrillation in patients with cardiac valve disease.

    abstract：BACKGROUND:Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodeling remains unknown. METHODS:Hematoxylin and eosin (H&E) and Masson's trichrome stains were used to...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01478-1

    authors： Chen Y,Liu F,Han F,Lv L,Tang CE,Xie Z,Luo F

    更新日期：2020-05-06 00:00:00

  • Atrophic inferior vena cava is a marker of chronicity of intra-filter and inferior vena cava thrombosis: based on CT findings.

    abstract：BACKGROUND:A permanently indwelling filter in the inferior vena cava (IVC) may induce caval thrombosis, which could develop and evolve from an acute to a chronic phase. The differential diagnosis of acute and chronic thromboses determines the treatment strategy. The role of computed tomography (CT) in diagnosing acute ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-018-0799-z

    authors： Chen L,Shi W,Gu J,He X,Lou W

    更新日期：2018-04-11 00:00:00

  • Prasugrel or ticagrelor relative to clopidogrel in triple-antiplatelet treatment combined with glycoprotein IIb/IIIa inhibitor for patients with STEMI undergoing PCI: a meta-analysis.

    abstract：BACKGROUND:For patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), the efficacy and safety of novel P2Y12 antagonists, including prasugrel or ticagrelor, has not been established relative to that of the clopidogrel-based triple-antiplatelet treatments (T...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-020-01403-6

    authors： Wang Z,Zhou DY,Su Y,Si LY,Xu Q

    更新日期：2020-03-12 00:00:00

  • Value of the Barthel scale in prognostic prediction for patients with cerebral infarction.

    abstract：BACKGROUND:This study aims to evaluate the ADL(activity of daily living) of patients with acute cerebral infarction through BI scoring, in order to observe its predictive value in the prognosis of these patients. METHODS:According to the inclusion and exclusion criteria, patients with acute anterior circulation cerebr...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-019-01306-1

    authors： Li QX,Zhao XJ,Wang Y,Wang DL,Zhang J,Liu TJ,Peng YB,Fan HY,Zheng FX

    更新日期：2020-01-13 00:00:00

  • Left atrial appendage morphology, echocardiographic characterization, procedural data and in-hospital outcome of patients receiving left atrial appendage occlusion device implantation: a prospective observational study.

    abstract：BACKGROUND:Implantation of left atrial appendage (LAA) occlusion devices was shown to be a feasible and effective alternative to oral anticoagulation in patients with non-valvular atrial fibrillation. However, only few data about in-hospital and peri-procedural data are currently available. This study aims to report ab...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-016-0200-z

    authors： Fastner C,Behnes M,Sartorius B,Yildiz M,Mashayekhi K,El-Battrawy I,Lehmann R,Baumann S,Becher T,Borggrefe M,Akin I

    更新日期：2016-01-28 00:00:00

  • Meta-analysis of the growth rates of abdominal aortic aneurysm in the Chinese population.

    abstract：BACKGROUND:Several studies on the growth rates of abdominal aortic aneurysm (AAA) in Chinese population have been conducted; however, this issue remains unclear. The aim of this study is to systematically review published data of the AAA growth rates among people in China. METHODS:We conducted a comprehensive search o...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-019-1160-x

    authors： Huang T,Liu S,Huang J,Xu B,Bai Y,Wang W

    更新日期：2019-08-22 00:00:00

  • Impact of the introduction of drug eluting stents on clinical outcomes in patients undergoing percutaneous and surgical coronary artery revascularisation procedures in Western Australia.

    abstract：BACKGROUND:Increasing rates of percutaneous coronary intervention (PCI) and decreasing rates of coronary artery bypass graft (CABG) surgery followed the introduction of drug eluting stents in Western Australia in 2002. We assessed the impact of these changes on one-year outcomes for the total population of patients und...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2261-13-47

    authors： Sanfilippo FM,Rankin JM,Hobbs MS,Nguyen M,Knuiman MW,Berg P,Whitford EG,Hendriks R,Hockings BE,Muhlmann M,Newman M,Larbalestier R,Gilfillan I,Briffa TG

    更新日期：2013-07-05 00:00:00

  • Distribution, size, shape, growth potential and extent of abdominal aortic calcified deposits predict mortality in postmenopausal women.

    abstract：BACKGROUND:Aortic calcification is a major risk factor for death from cardiovascular disease. We investigated the relationship between mortality and the composite markers of number, size, morphology and distribution of calcified plaques in the lumbar aorta. METHODS:308 postmenopausal women aged 48-76 were followed for...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-10-56

    authors： Nielsen M,Ganz M,Lauze F,Pettersen PC,de Bruijne M,Clarkson TB,Dam EB,Christiansen C,Karsdal MA

    更新日期：2010-11-10 00:00:00

  • Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts.

    abstract：BACKGROUND:Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC). However, the detailed molecular mechanism and targeted therapies for SIC are still lacking. Therefore, we sought to investigate the likely protective...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-020-01529-7

    authors： Ji J,Liu Z,Hong X,Liu Z,Gao J,Liu J

    更新日期：2020-05-24 00:00:00

  • Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques.

    abstract：BACKGROUND:Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence of these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) and within thrombi adjacent to ruptures has not been described, nor an association with iro...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/1471-2261-9-27

    authors： Tavora FR,Ripple M,Li L,Burke AP

    更新日期：2009-06-23 00:00:00

  • Ticagrelor and clopidogrel suppress NF-κB signaling pathway to alleviate LPS-induced dysfunction in vein endothelial cells.

    abstract：BACKGROUND:Ticagrelor and clopidogrel, P2Y12 receptor antagonists, can prevent thrombotic events and are used to treat cardiovascular diseases such as acute coronary syndrome and chronic obstructive pulmonary disease, in which inflammation is involved. Moreover, NF-B is the central regulator of inflammation. Thus, we s...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-019-01287-1

    authors： Jia Z,Huang Y,Ji X,Sun J,Fu G

    更新日期：2019-12-30 00:00:00

  • Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention.

    abstract：BACKGROUND:Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. METHODS:Published literatures were identified via a computerized literature search of CENTRAL, PubMe...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-019-1071-x

    authors： Zhao XT,Zhang CF,Liu QJ

    更新日期：2019-06-14 00:00:00

  • Balloon-expandable transcatheter aortic valve implantation with or without pre-dilation - results of a meta-analysis of 3 multicenter registries.

    abstract：BACKGROUND:To evaluate the outcomes of transcatheter aortic valve implantation (TAVI) without balloon aortic valvuloplasty (BAV) in a real-world setting through a patient-level meta-analysis. METHODS:The meta-analysis included patients of three European multicenter, prospective, observational registry studies that com...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12872-019-1151-y

    authors： Ashauer JO,Bonaros N,Kofler M,Schymik G,Butter C,Romano M,Bapat V,Strauch J,Schröfel H,Busjahn A,Deutsch C,Bramlage P,Kurucova J,Thoenes M,Baldus S,Rudolph TK

    更新日期：2019-07-19 00:00:00

  • INvestigation on Routine Follow-up in CONgestive HearT FAilure Patients with Remotely Monitored Implanted Cardioverter Defibrillators SysTems (InContact).

    abstract：BACKGROUND:In heart failure (HF) patients with implantable cardioverter defibrillators (ICD) or cardiac resynchronisation therapy defibrillators (CRT-D), remote monitoring has been shown to result in at least non-inferior outcomes relative to in-clinic visits. We aimed to provide further evidence for this effect, and t...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12872-018-0864-7

    authors： Hansen C,Loges C,Seidl K,Eberhardt F,Tröster H,Petrov K,Grönefeld G,Bramlage P,Birkenhauer F,Weiss C

    更新日期：2018-06-28 00:00:00

  • High platelet reactivity affects the clinical outcomes of patients undergoing percutaneous coronary intervention.

    abstract：BACKGROUND:The association of platelet reactivity and clinical outcomes, especially stent thrombosis, was not so clear. We sought to investigate whether high platelet reactivity affects clinical outcomes of patients with drug eluting stents (DESs) implantation. METHODS:All enrolled individuals treated with DESs implan...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-016-0394-0

    authors： Zhang JJ,Gao XF,Ge Z,Tian NL,Liu ZZ,Lin S,Ye F,Chen SL

    更新日期：2016-11-29 00:00:00

  • Cost-of-illness studies in heart failure: a systematic review 2004-2016.

    abstract：BACKGROUND:Heart failure is a major and growing medical and economic problem worldwide as 1-2% of the healthcare budget are spent for heart failure. The prevalence of heart failure has increased over the past decades and it is expected that there will be further raise due to the higher proportion of elderly in the west...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-018-0815-3

    authors： Lesyuk W,Kriza C,Kolominsky-Rabas P

    更新日期：2018-05-02 00:00:00

  • Effects of care pathways on the in-hospital treatment of heart failure: a systematic review.

    abstract：BACKGROUND:Care pathways have become a popular tool to enhance the quality of care by improving patient outcomes, promoting patient safety, increasing patient satisfaction, and optimizing the use of resources. We performed a disease specific systematic review to determine how care pathways in the hospital treatment of ...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2261-12-81

    authors： Kul S,Barbieri A,Milan E,Montag I,Vanhaecht K,Panella M

    更新日期：2012-09-25 00:00:00

  • Findings of transoesophageal echocardiogram in appropriately anticoagulated patients with persistent atrial fibrillation prior to planned cardioversion.

    abstract：BACKGROUND:To evaluate a diagnostic value of transoesophageal echocardiogram (TEE) in appropriately anticoagulated patients with a non-valvular atrial fibrillation (AF) and to establish possible additional indications for TEE; to evaluate the incidence of left atrial (LA) thrombi in appropriately anticoagulated patient...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章

    doi：10.1186/s12872-017-0503-8

    authors： Barysienė J,Žebrauskaitė A,Petrikonytė D,Marinskis G,Aidietienė S,Aidietis A

    更新日期：2017-02-23 00:00:00

  • Evaluation of a self-management patient education program for patients with chronic heart failure undergoing inpatient cardiac rehabilitation: study protocol of a cluster randomized controlled trial.

    abstract：BACKGROUND:Chronic heart failure requires a complex treatment regimen on a life-long basis. Therefore, self-care/self-management is an essential part of successful treatment and comprehensive patient education is warranted. However, specific information on program features and educational strategies enhancing treatment...

    journal_title：BMC cardiovascular disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1471-2261-13-60

    authors： Meng K,Musekamp G,Seekatz B,Glatz J,Karger G,Kiwus U,Knoglinger E,Schubmann R,Westphal R,Faller H

    更新日期：2013-08-23 00:00:00

  • Deep vein thrombosis due to May-Thurner syndrome: a case report.

    abstract：BACKGROUND:May-Thurner syndrome (MTS) or Cockett's syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications of MTS include deep vein thrombus formation and even life-threatening pulmonary embolism. CASE PRE...

    journal_title：BMC cardiovascular disorders

    pub_type：

    doi：10.1186/s12872-020-01515-z

    authors： Meng Y,Qin H,Ma Q,Zhang J,Zhang B,Pang H,Yin Q,Tian H

    更新日期：2020-05-19 00:00:00