Abstract:
BACKGROUND:Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence of these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) and within thrombi adjacent to ruptures has not been described, nor an association with iron-containing macrophages within unstable plaques. METHODS:We studied 61 acute ruptures, 15 organizing ruptures, 31 thin cap fibroatheromas, and 28 fibroatheromas from 72 sudden coronary death victims by immunohistochemical and histochemical techniques. Inflammatory cells were typed with anti-CD68 (macrophages), anti-BP-30 (neutrophil bactericidal glycoprotein), and anti-MPO. Iron was localized by Mallory's Prussian blue stain. In selected plaques alpha smooth muscle actin (DAKO, Carpinteria, CA, clone M0851) was performed. RESULTS:MPO positive cells were present in 79% of ruptured caps, 28% of thin cap fibroatheroma, and no fibroatheromas; neutrophils were present in 72% of ruptures, 8% of thin cap fibroatheromas, and no fibroatheromas. Iron containing foam cells were present in the caps of 93% of acute ruptures, of 85% of organizing ruptures, 20% of thin cap atheromas, and 10% of fibroatheromas. MPO positive cells were more frequent in occlusive than non-occlusive thrombi adjacent to ruptures (p = .006) and were more numerous in diabetics compared to non-diabetics (p = .002) CONCLUSION:Unstable fibrous caps are more likely to contain MPO-positive cells, neutrophils, and iron-containing macrophages than fibrous caps of stable fibroatheromas. MPO-positive cells in thrombi adjacent to disrupted plaques are associated with occlusive thrombi and are more numerous in diabetic patients.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Tavora FR,Ripple M,Li L,Burke APdoi
10.1186/1471-2261-9-27subject
Has Abstractpub_date
2009-06-23 00:00:00pages
27issn
1471-2261pii
1471-2261-9-27journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Diabetes is one of the major risk factors for cardiomyopathy and heart failure with reduced ejection fraction (EF) and highly associated with left ventricular (LV) dysfunction in human. This study aimed 1) to noninvasively assess cardiac function using echocardiography; 2) to test the hypothesis that like di...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0133-y
更新日期:2015-10-30 00:00:00
abstract:BACKGROUND:Adverse effects, treatment resistance and high costs associated with pharmacological treatment of hypertension have led to growing interest in non-pharmacological complementary therapies such as music interventions. This meta-analysis aims to provide an overview of reported evidence on the efficacy of music ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0244-0
更新日期:2016-04-19 00:00:00
abstract:BACKGROUND:Candida prosthetic endocarditis is associated with high mortality rates and valve replacement surgery, together with antifungal treatment, play a major role in eradicating the fungal infection. Valve reoperations in these scenarios may be relatively common due to the high infection relapse rates and, in some...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01755-z
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND:In heart failure (HF) patients with implantable cardioverter defibrillators (ICD) or cardiac resynchronisation therapy defibrillators (CRT-D), remote monitoring has been shown to result in at least non-inferior outcomes relative to in-clinic visits. We aimed to provide further evidence for this effect, and t...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12872-018-0864-7
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. METHODS:This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, en...
journal_title:BMC cardiovascular disorders
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s12872-016-0380-6
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:This study aimed to compare the adverse clinical outcomes associated with a short and a prolonged duration of Dual Anti-Platelet Therapy (DAPT) in patients with Diabetes Mellitus (DM) after undergoing Percutaneous Coronary Intervention (PCI). METHODS:Medline/PubMed, EMBASE and the Cochrane library were sear...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0343-y
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardi...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0502-9
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the difference in effects of beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those with reduced ejection fraction (rEF). METHODS:Data were assessed of 3508 consecutive IHD patients w...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-021-01850-9
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:Despite the potentially life-saving benefits of the implantable cardioverter-defibrillator (ICD), a significant group of patients experiences emotional distress after ICD implantation. Different psychosocial interventions have been employed to improve this condition, but previous reviews have suggested that ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,评审
doi:10.1186/1471-2261-9-56
更新日期:2009-12-29 00:00:00
abstract:BACKGROUND:Del Nido cardioplegia (DNC) has been proven safe and effective in pediatric patients. However, the use of DNC in adult undergoing cardiovascular surgery lacks support with substantial evidence. This study aimed to evaluate the efficacy of DNC as a cardioplegia of prophylaxis to ventricular arrhythmias associ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01844-z
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based intervention, for men and women aged between 45 and 64 years without pre-existing coronary heart disease, ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-8-18
更新日期:2008-07-26 00:00:00
abstract:BACKGROUND:This study aimed to determine whether midlife obesity predicts heart failure (HF) over an extended follow-up into old age. METHODS:We studied 7495 men (from a population sample of 9,998 men) without HF, who were 47-55 years old when investigated in 1970 to 1973. All participants were followed up for 35 year...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0008-2
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:The prevalence of acute coronary syndrome (ACS) continues to increase among young Chinese adults. Homocysteine (HCY) has been suggested as a promoter of atherosclerosis leading to coronary artery disease (CAD). Yet, it remains uncertain whether HCY is associated with the ACS and the severity of coronary arte...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-021-01869-y
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Periostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin in left ventricular remodeling of streptozototin (STZ)-induced diabetic rats. The aim of the present study was to observe the expression of periostin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0084-3
更新日期:2015-08-18 00:00:00
abstract:BACKGROUND:Up to over half of the patients with ST-segment elevation myocardial infarction (STEMI) are reported to undergo spontaneous reperfusion without therapeutic interventions. Our objective was to evaluate the applicability of T wave inversion in electrocardiography (ECG) of patients with STEMI as an indicator of...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-021-01851-8
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:In Denmark and other countries, there has been a shift in the management of patients with an implantable cardioverter defibrillator (ICD) with remote device monitoring largely replacing in-hospital visits. Less patient-nurse and patient-physician interaction may lead to gaps in patients' quality of care and ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0872-7
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:This study aimed at investigating the CV health and CV disease knowledge in terms of LS7 score among 3 age groups in Hong Kong. METHODS:A cross-sectional multicenter observational study was conducted to observe the CV health and disease risk knowledge in Hong Kong. Elderly subjects were recruited from 15 el...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-019-1171-7
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:Percutaneous coronary interventions (PCI) of bifurcation lesions is technically challenging and associated with lower success rates and higher frequency of adverse outcomes. In the present study, we aimed to evaluate the immediate and long-term treatment effect and adverse events of a new modified jailed-bal...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0995-x
更新日期:2019-01-10 00:00:00
abstract:BACKGROUND:A permanently indwelling filter in the inferior vena cava (IVC) may induce caval thrombosis, which could develop and evolve from an acute to a chronic phase. The differential diagnosis of acute and chronic thromboses determines the treatment strategy. The role of computed tomography (CT) in diagnosing acute ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0799-z
更新日期:2018-04-11 00:00:00
abstract:BACKGROUND:Factors affecting heart rate variability (HRV) in patients with atrial septal defect (ASD) have not been clarified. This study sought to identify those factors and establish a preliminary risk model. METHODS:A total of 154 patients with ASD who underwent transcatheter closure and met the study requirements ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01699-4
更新日期:2020-09-11 00:00:00
abstract:BACKGROUND:The aim was to investigate the extent to which it is possible to diagnose suspected carotid calcification from dental panoramic radiography (PR) and to establish an association to periodontal risk. METHODS:824 PRs from one dental practice were investigated. Parameters considered were gender, age, bone loss ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-11-67
更新日期:2011-11-09 00:00:00
abstract:BACKGROUND:Timely restoration of bloodflow acute ST-segment elevation myocardial infarction (STEMI) reduces myocardial damage and improves prognosis. The objective of this study was describe the association of demographic factors with hospitalisation rates for STEMI and time to angiography, Percutaneous Coronary Interv...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01487-0
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:In subjects with hypercholesterolaemia, cholesterol values remain above guideline levels. One of the limiting factors to the achievement of goals in such patients is therapeutic non-adherence. The aim of this study is to assess the effectiveness of an intervention designed to improve control of hypercholeste...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2261-15-8
更新日期:2015-01-19 00:00:00
abstract:BACKGROUND:It is uncertain whether gender differences in outcome after primary percutaneous coronary intervention (PCI) are only attributable to different baseline characteristics or additional factors. METHODS:Databases of two German myocardial infarction network registries were combined with a total of 1104 consecut...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2261-14-71
更新日期:2014-06-02 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-91
更新日期:2012-10-17 00:00:00
abstract:BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1174-4
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:Arterial stiffness predicts the future risk of macro- and micro-vascular diseases. Only a few studies have reported longitudinal changes. The present study aimed to investigate the progression rate of arterial stiffness and the factors influencing stiffness progression in a Han Chinese population residing in...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0093-2
更新日期:2015-09-16 00:00:00
abstract:BACKGROUND:Atherosclerosis (AT) is a chronic inflammatory disease characterized by the accumulation of inflammatory cells, lipoproteins and fibrous tissue in the walls of arteries. AT is the primary cause of heart attacks and stroke and is the leading cause of death in Western countries. To date, the pathogenesis of AT...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-13-4
更新日期:2013-01-16 00:00:00
abstract:BACKGROUND:Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates the production of cellular oxidants and it may also promote vascu...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2261-12-75
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogen...
journal_title:BMC cardiovascular disorders
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2261-12-11
更新日期:2012-02-27 00:00:00