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Association between markers of glycemia and carotid intima-media thickness: the MARK study.

Abstract：

BACKGROUND:Carotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients. METHODS:This study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose, 104 subjects classified as prediabetes and 92 with type 2 diabetes mellitus. Carotid ultrasound was used to measure C-IMT and the presence of plaques. Fasting plasma glucose (mg/dl) and glycated hemoglobin (%) (HbA1c) were measured using standard enzymatic automated methods. Postprandial glucose (mg/dl) was self-measured by patients at home 2 h after meals (breakfast, lunch and dinner) for 1 day. RESULTS:The C-IMT shows a positive correlation with fasting plasma glucose, postprandial glucose and HbA1c. Multiple linear regression analysis showed a positive association between HbA1c and C-IMT, with a 0.016 mm and 0.019 mm increase in mean and maximum C-IMT per 1 % increase in HbA1c. In addition, an association between fasting plasma glucose and C-IMT was found with an increase of 0.004 and 0.005 mm in mean and maximum C-IMT per 10 mg/dl in fasting plasma glucose. We also observed a graded association between fasting plasma glucose, postprandial glucose and HbA1c and the presence of carotid target organ damage (TOD), with an odds ratio of 1.013, 1.010 and 1.425, respectively. CONCLUSION:The results of this study suggest that the fasting plasma glucose and HbA1c, but not postprandial glucose, are associated with C-IMT media and maximum. The patients who present with a metabolic glucose alteration have more risk of developing carotid TOD. TRIAL REGISTRATION:ClinicalTrials.gov; Identifier: NCT01428934 .

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Gomez-Marcos MA,Gomez-Sanchez L,Patino-Alonso MC,Recio-Rodriguez JI,Regalado NG,Ramos R,Marti R,Agudo-Conde C,Rodriguez-Sanchez E,Maderuelo-Fernandez JA,Garcia-Ortiz L,MARK Group.

doi

10.1186/s12872-016-0380-6

subject

Has Abstract

pub_date

2016-10-28 00:00:00

pages

203

issue

issn

1471-2261

pii

10.1186/s12872-016-0380-6

journal_volume

pub_type

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Association between markers of glycemia and carotid intima-media thickness: the MARK study.