Abstract:
BACKGROUND:Increased arterial stiffness (iAS) and microalbuminuria (MAU), which may occur simultaneously or separately in the general population and share similar risk factors, are markers of macro- and microvascular injuries. Our research investigated the comorbidity of iAS and MAU in the middle-aged population and examined the heterogeneous effects of metabolic risk factors on iAS and MAU. METHODS:We selected 11,911 individuals aged 45 to 60 years who underwent a health examination at the 3rd Xiangya Hospital between 2010 and 2014. Metabolic syndrome (MetS) was determined according to IDF/NHLBI/AHA-2009 criteria. Multinomial logistic regression was applied to evaluate the influence of MetS, components of MetS and clusters of MetS on the co-occurrence (MAU(+)/iAS(+)) or non-co-occurrence (MAU(+)/iAS(-) and MAU(-)/iAS(+)) of MAU and iAS. RESULTS:Reference group was MAU(-)/iAS(-). A positive effect of MetS on the presence of MAU(+)/iAS(-), MAU(-)/iAS(+), or MAU(+)/iAS(+) is listed in ascending order based on odds ratios (ORs = 2.11, 2.41, 4.61, respectively; P < 0.05). Compared with MAU(+)/iAS(-), Elevated blood pressure (BP) (OR = 1.62 vs. 4.83, P < 0.05), triglycerides(TG) (OR = 1.20 vs. 1.37, P < 0.05) were more strongly associated with MAU(-)/iAS(+), whereas fasting blood glucose (FBG) was less associated (OR = 1.37 vs. 1.31, P < 0.05). Decreased high-density lipoprotein cholesterol(HDL-c) (OR = 1.84, P < 0.01) and elevated waist circumference(WC) (OR = 1.28 P < 0.01) were the most strongly associated with MAU(+)/iAS(-). Compared with the individuals without MetS, individuals with the elevated BP, FBG, TG and decreased HDL-c cluster had the greatest likelihood of presenting a MAU(-)/iAS(+) (OR = 5.98, P < 0.01) and MAU(+)/iAS(+) (OR = 13.17, P < 0.01), these likelihood was even greater than the cluster with simultaneous alteration in all five MetS components (OR = 3.89 and 10.77, respectively, P < 0.01), which showed the most strongly association with MAU(+)/iAS(+) (OR = 5.22, P < 0.01). CONCLUSION:Based on the heterogeneous influences of MetS-related risk factors on MAU and iAS, these influences could be selectively targeted to identify different types of vascular injuries.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Miao R,Wu L,Ni P,Zeng Y,Chen Zdoi
10.1186/s12872-018-0817-1subject
Has Abstractpub_date
2018-05-04 00:00:00pages
83issue
1issn
1471-2261pii
10.1186/s12872-018-0817-1journal_volume
18pub_type
杂志文章abstract:BACKGROUND:To investigate whether B-type natriuretic peptide (NP)-guided treatment of heart failure (HF) patients improved their health related quality of life (Hr-QoL) compared to routine HF treatment, and whether changes in Hr-QoL differed depending on whether the patient was a responder to NP-guided therapy or not. ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12872-016-0221-7
更新日期:2016-02-13 00:00:00
abstract:BACKGROUND:It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS:Forty two patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic re...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-9-37
更新日期:2009-08-09 00:00:00
abstract:BACKGROUND:Certain conditions characterised by blood vessel occlusion or vascular spasm have been found to cluster together in epidemiological studies. However the biological causes for these associations remain controversial. This study used a classical twin design to examine whether these conditions are linked throug...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-4-20
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS:Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-019-1187-z
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:Since the introduction of high-sensitivity troponin assays a greater proportion of atrial fibrillation (AF) patients present with dynamic troponin elevations. We hypothesize that significant coronary artery disease (CAD) causes relative ischemia in the setting of a rapid heart rate resulting in dynamic tropo...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-017-0601-7
更新日期:2017-06-27 00:00:00
abstract:BACKGROUND:Large artery stiffening and wave reflections are independent predictors of adverse events. To date, their assessment has been limited to specialised techniques and settings. A new, more practical method allowing assessment of central blood pressure from waveforms recorded using a conventional automated oscil...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-48
更新日期:2012-06-26 00:00:00
abstract:BACKGROUND:Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates the production of cellular oxidants and it may also promote vascu...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2261-12-75
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investi...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0646-7
更新日期:2017-07-28 00:00:00
abstract:BACKGROUND:There is limited information about any association between the onset of atrial fibrillation (AF) and the presence of valvular disease. METHODS:We retrospectively examined 940 patients in sinus rhythm, examined by echocardiography in 1996. During 11 years of follow-up, we assessed the incidence of AF and out...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-92
更新日期:2012-10-18 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0259-6
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND:Effects of β-blockers on outcomes in patients with chronic heart failure (CHF) and atrial fibrillation (AF) is still in controversy. METHODS:Searching was conducted by using keywords "atrial fibrillation", and "heart failure" in PubMed, MEDLINE and Embase databases before November 30, 2017. Prospective stud...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1079-2
更新日期:2019-06-03 00:00:00
abstract:BACKGROUND:Fabry disease is caused by mutations in the α-galactosidase A (GLA) gene, which is located in X-chromosome coding for the lysosomal enzyme of GLA. Among many gene mutations, E66Q mutation is under discussion for its pathogenicity because there is no clinical report showing pathological evidence of Fabry dise...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0262-y
更新日期:2016-05-10 00:00:00
abstract:BACKGROUND:High blood glucose impairs voltage-gated K+ (Kv) channel-mediated vasodilation in rat coronary artery smooth muscle cells (CSMCs) via oxidative stress. Advanced glycation end product (AGE) and receptor for AGE (RAGE) axis has been found to impair coronary dilation by reducing Kv channel activity in diabetic ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01613-y
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1174-4
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:Although various iatrogenic complications could be observed in the process of permanent pacemaker implantation, pacemaker electrode mistakenly implanted into left ventricle via subclavian artery and aortic valve has not been reported. CASE PRESENTATION:Herein, we reported a 71-year-old woman with permanent ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0032-2
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival. METHODS:This was a retrospective study of 78,806 patients who underwent heart valve surgery be...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0725-9
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:Globally, rheumatic heart disease (RHD) remains an important cause of heart disease. In Australia it particularly affects younger Indigenous and older non-Indigenous Australians. Despite its impact there is limited understanding of the factors influencing outcome following surgery for RHD. METHODS:The Austr...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-015-0094-1
更新日期:2015-09-23 00:00:00
abstract:BACKGROUND:Annually > 10% of patients with atrial fibrillation on oral anticoagulation undergo invasive procedures. Optimal peri-procedural management of anticoagulation, as judged by major bleeding and thromboembolic events, especially in the elderly, is still debated. METHODS:Procedures from 1442 patients were evalu...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01766-w
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Optimal treatment of acute ST-elevation myocardial infarction (STEMI) involves rapid diagnosis, and transfer to a cardiac centre capable of percutaneous coronary intervention (PCI) for immediate mechanical revascularisation. Successful treatment requires rapid return of perfusion to the myocardium achieved b...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-44
更新日期:2014-04-04 00:00:00
abstract:BACKGROUND:Metabolic Syndrome (MetS) and Non-communicable diseases (NCDs) are alarmingly increasing in low-income countries. Yet, very limited is known about the prevalence and risk factors associated with MetS in Ethiopia. METHODS:A cross-sectional study was conducted among adult outpatients (N = 325) at St. Paul's H...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1201-5
更新日期:2019-10-26 00:00:00
abstract:BACKGROUND:Hyperlipidemia and hypertension are well-established risk factors for recurrent cardiovascular events among patients with ischemic heart disease (IHD). Despite national recommendations, concordance with guidelines for LDL cholesterol and blood pressure remains inadequate. The objectives of this study were to...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-6-6
更新日期:2006-02-09 00:00:00
abstract:BACKGROUND:To evaluate the outcomes of transcatheter aortic valve implantation (TAVI) without balloon aortic valvuloplasty (BAV) in a real-world setting through a patient-level meta-analysis. METHODS:The meta-analysis included patients of three European multicenter, prospective, observational registry studies that com...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1151-y
更新日期:2019-07-19 00:00:00
abstract:BACKGROUND:We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril. METHODS:Thickening of the a...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-9-10
更新日期:2009-03-03 00:00:00
abstract:BACKGROUND:Metabolic syndrome is associated with cardio-metabolic risk factors and lipid abnormalities. Previous studies evaluated the dietary habits and nutrient intakes among patients with metabolic syndrome; however the association between metabolic risk factors and adiponectin with dietary diversity score (DDS) in ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0807-3
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Due to increased CAD risk factors in Saudi Arabia, research on more feasible and predictive biomarkers is needed. We aimed to evaluate glycated hemoglobin (HbA1c) as a predictor of CAD in low-risk profile non-diabetic patien...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-01302-5
更新日期:2019-12-21 00:00:00
abstract::After publication of the original article [1], we were notified that an author's name is not complete. ...
journal_title:BMC cardiovascular disorders
pub_type: 已发布勘误
doi:10.1186/s12872-019-1195-z
更新日期:2019-10-18 00:00:00
abstract:BACKGROUND:Risk stratification is recommended as the key step to prevent contrast-associated acute kidney injury (CA-AKI) among at-risk patients following coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). Patients with hypoalbuminemia are prone to CA-AKI and do not have their own risk stratifi...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01689-6
更新日期:2020-08-31 00:00:00
abstract:BACKGROUND:Loss-of-function mutations of human cardiac sodium channel gene SCN5A induce a wide range of arrhythmic disorders. Mutation carriers with co-existing conditions such as congenital heart diseases and histories of cardiac surgeries, could develop complex arrhythmic events that are difficult to diagnose. CASE ...
journal_title:BMC cardiovascular disorders
pub_type:
doi:10.1186/s12872-020-01601-2
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Systematic investigation and analysis of cardiovascular health status (CVHS) of Chinese women is rare. This study aimed to assess CVHS and atherosclerotic cardiovascular disease (ASCVD) burden in the Chinese women physicians (CWP) and community-based non-physician cohort (NPC). METHODS:In this prospective, ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01748-y
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:Depression is common in patients with cardiometabolic diseases but little is known about the relationship, if any, between cardiovascular risk factor values and depressive symptoms in patients with these conditions. The objective of this paper is to study the association between cardiovascular risk factors a...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-139
更新日期:2014-10-28 00:00:00