Abstract:
BACKGROUND:Valvular heart disease is a leading cause of cardiovascular mortality, especially in China. More than a half of valvular heart diseases are caused by acute rheumatic fever. microRNA is involved in many physiological and pathological processes. However, the miRNA profile of the rheumatic valvular heart disease is unknown. This research is to discuss microRNAs and their target gene pathways involved in rheumatic heart valve disease. METHODS:Serum miRNA from one healthy individual and four rheumatic heart disease patients were sequenced. Specific differentially expressed miRNAs were quantified by Q-PCR in 40 patients, with 20 low-to-moderate rheumatic mitral valve stenosis patients and 20 severe mitral valve stenosis patients. The target relationship between certain miRNA and predicted target genes were analysis by Luciferase reporter assay. The IL-1β and IL1R1 expression levels were analyzed by immunohistochemistry and western blot in the mitral valve from surgery of mitral valve replacement. RESULTS:The results showed that 13 and 91 miRNAs were commonly upregulated or downregulated in all four patients. Nine miRNAs, 1 upregulated and 8 downregulated, that had a similar fold change in all 4 patients were selected for quantitative PCR verification. The results showed similar results from miRNA sequencing. Within these 9 tested miRNAs, hsa-miR-205-3p and hsa-miR-3909 showed a low degree of dispersion between the members of each group. Hsa miR-205-3p and hsa-miR-3909 were predicted to target the 3'UTR of IL-1β and IL1R1 respectively. This was verified by luciferase reporter assays. Immunohistochemistry and Western blot results showed that the mitral valve from rheumatic valve heart disease showed higher levels of IL- 1β and IL1R1 expression compared with congenital heart valve disease. This suggested a difference between rheumatic heart valve disease and other types of heart valve diseases, with more inflammatory responses in the former. CONCLUSION:In the present study, by next generation sequencing of miRNAs, it was revealed that interleukin 1β and interleukin 1 receptor 1 was involved in rheumatic heart diseases. And this is useful for diagnosis and understanding of mechanism of rheumatic heart disease.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Lu Q,Sun Y,Duan Y,Li B,Xia J,Yu S,Zhang Gdoi
10.1186/s12872-018-0788-2subject
Has Abstractpub_date
2018-03-16 00:00:00pages
53issue
1issn
1471-2261pii
10.1186/s12872-018-0788-2journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Heart failure (HF) patients with diabetes (DM) have an adverse prognosis and reduced functional capacity, which could be associated with cardiac fibrosis, increased chamber stiffness and reduced left ventricular (LV) contractile reserve. Galectin-3 (Gal-3) and fibulin-1 are circulating biomarkers potentially...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0437-6
更新日期:2017-01-10 00:00:00
abstract:BACKGROUND:The aim of this study was to assess among pacemaker patients their overall satisfaction with the pacemaker system, pain, soreness/discomfort, cosmetic results, restrictions due to impaired movement of the shoulder/arm/chest, related sleep disturbances, and concern about possible device malfunction. METHODS:...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0849-6
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) with poor parasympathetic function being implicated as an underlying factor. Factors related to parasympathetic function, commonly assessed by heart rate recovery (HRR) following maximal exercise, are currently no...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0264-9
更新日期:2016-05-10 00:00:00
abstract:BACKGROUND:With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin therapy. It is not known how this affects statin eligibility in the Africa and Middle East Region. M...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-019-1034-2
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:Adverse effects, treatment resistance and high costs associated with pharmacological treatment of hypertension have led to growing interest in non-pharmacological complementary therapies such as music interventions. This meta-analysis aims to provide an overview of reported evidence on the efficacy of music ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0244-0
更新日期:2016-04-19 00:00:00
abstract:BACKGROUND:Gigantic left atrium is defined in the current literature as an excessive dilatation of the left atrium above 65mm. Chronic mitral valve disease is associated with the development of thrombus in the left atrium in up to 19% of all cases of mitral insufficiency and appropriate treatment must be initiated to p...
journal_title:BMC cardiovascular disorders
pub_type:
doi:10.1186/s12872-019-01279-1
更新日期:2020-02-21 00:00:00
abstract:BACKGROUND:Timely restoration of bloodflow acute ST-segment elevation myocardial infarction (STEMI) reduces myocardial damage and improves prognosis. The objective of this study was describe the association of demographic factors with hospitalisation rates for STEMI and time to angiography, Percutaneous Coronary Interv...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01487-0
更新日期:2020-05-14 00:00:00
abstract:BACKGROUND:May-Thurner syndrome (MTS) or Cockett's syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications of MTS include deep vein thrombus formation and even life-threatening pulmonary embolism. CASE PRE...
journal_title:BMC cardiovascular disorders
pub_type:
doi:10.1186/s12872-020-01515-z
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based intervention, for men and women aged between 45 and 64 years without pre-existing coronary heart disease, ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-8-18
更新日期:2008-07-26 00:00:00
abstract:BACKGROUND:Diabetes patients presenting with ST-segment elevation myocardial infarction (STEMI) scheduled for primary percutaneous coronary intervention (PCI) have an increased risk of contrast induced-acute kidney injury (CI-AKI). The effects of continuous use of metformin on kidney function are still controversial in...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01474-5
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD). METHODS:A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 ± 12, male 64%). HRV analysis was ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-105
更新日期:2012-11-15 00:00:00
abstract:BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1174-4
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:Hypertension is a common comorbidity in patients with heart failure and may contribute to development and course of disease, but the importance of a history of hypertension in patients with prevalent heart failure remains uncertain. METHODS:3078 consecutively hospitalized heart failure patients (NYHA classe...
journal_title:BMC cardiovascular disorders
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/1471-2261-12-30
更新日期:2012-04-25 00:00:00
abstract:BACKGROUND:Optimal treatment of acute ST-elevation myocardial infarction (STEMI) involves rapid diagnosis, and transfer to a cardiac centre capable of percutaneous coronary intervention (PCI) for immediate mechanical revascularisation. Successful treatment requires rapid return of perfusion to the myocardium achieved b...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-44
更新日期:2014-04-04 00:00:00
abstract:BACKGROUND:Cardiovascular secondary preventive recommendations are often not reached. We investigated whether a nurse-led telephone-based follow-up could improve the implementation of a new guideline within a year after its release. METHODS:In February 2013, a new secondary preventive guideline for diabetic patients w...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12872-016-0252-0
更新日期:2016-04-30 00:00:00
abstract:BACKGROUND:Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. β-blocker treatment is a key quality of care indicator in the Swedish national quality register for acute coronary care, Riks-HIA. Between...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01441-0
更新日期:2020-04-09 00:00:00
abstract:BACKGROUND:Cardiovascular diseases (CVDs) are one of the leading causes of death and disability in the world. Over 80% of CVD deaths take place in low-and middle-income countries. One-third of the population aged above 40 years suffers from Hypertension (HTN) and this is largely unreported as there is no registry for C...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2261-13-76
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodeling remains unknown. METHODS:Hematoxylin and eosin (H&E) and Masson's trichrome stains were used to...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01478-1
更新日期:2020-05-06 00:00:00
abstract:BACKGROUND:Coronary artery ectasia (CAE) is an uncommon finding in patients undergoing coronary angiography and acute myocardial infarction is an extremely uncommon condition in the presence of coronary artery ectasia. To date, 50 gene variants associated with coronary artery disease have been identified, but none appe...
journal_title:BMC cardiovascular disorders
pub_type:
doi:10.1186/s12872-019-01276-4
更新日期:2019-12-17 00:00:00
abstract:BACKGROUND:Transradial access (TRA) has been considered as the default choice in cardiac catheterization. Although infrequent, vascular complications of this approach remain. Recently, the distal transradial approach (dTRA) in cardiac catheterization was reported by interventionalists. METHODS:We retrieved the relevan...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,评审
doi:10.1186/s12872-020-01625-8
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:Higher creatine kinase (CK) activity is associated with the development of cardiovascular disease in black African populations. We compared CK activity and investigated associations of blood pressure with CK activity in black and white men as well as black and white women. METHODS:Ambulatory blood pressure,...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0315-2
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Anoxic coma following cardiac arrest is a common problem with ethical, social, and legal consequences. Except for unfavorable somatosensory-evoked potentials (SSEP) results, predictors of unfavorable outcome with a 100% specificity and a high sensitivity are lacking. The aim of the current research was to co...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-8-35
更新日期:2008-12-04 00:00:00
abstract:BACKGROUND:Ticagrelor and clopidogrel, P2Y12 receptor antagonists, can prevent thrombotic events and are used to treat cardiovascular diseases such as acute coronary syndrome and chronic obstructive pulmonary disease, in which inflammation is involved. Moreover, NF-B is the central regulator of inflammation. Thus, we s...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-01287-1
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:This study aimed to compare the adverse clinical outcomes associated with a short and a prolonged duration of Dual Anti-Platelet Therapy (DAPT) in patients with Diabetes Mellitus (DM) after undergoing Percutaneous Coronary Intervention (PCI). METHODS:Medline/PubMed, EMBASE and the Cochrane library were sear...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0343-y
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:Non-obstructive coronary artery disease (NOCAD) is a common finding on coronary angiography. Our goal was to evaluate the long-term prognosis of NOCAD patients with stable angina (SA). METHODS:The study cohort consisted of 7478 NOCAD patients with normal EF (≥ 50%), and SA who underwent coronary angiography...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0908-z
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:This study aims to evaluate the ADL(activity of daily living) of patients with acute cerebral infarction through BI scoring, in order to observe its predictive value in the prognosis of these patients. METHODS:According to the inclusion and exclusion criteria, patients with acute anterior circulation cerebr...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-01306-1
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Certain conditions characterised by blood vessel occlusion or vascular spasm have been found to cluster together in epidemiological studies. However the biological causes for these associations remain controversial. This study used a classical twin design to examine whether these conditions are linked throug...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-4-20
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Colchicine has been used as anti-inflammatory agent in pericardial effusion (PE). We sought to perform a meta-analysis of randomized trials assessing the efficacy and safety of colchicine in patients with pericarditis or postpericardiotomy syndrome (PPS). METHODS:In the systematic literature search followin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1190-4
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is a life-threatening arrhythmia that carries the high risk of thromboembolic complication. Stroke often develops in patients who undergo successful Cox Maze procedure, despite the fact that the procedure has shown a high rate of success in sinus conversion from AF. This study examin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-116
更新日期:2014-09-11 00:00:00
abstract:BACKGROUND:Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients. METHODS:Published literatures were identified via a computerized literature search of CENTRAL, PubMe...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-019-1071-x
更新日期:2019-06-14 00:00:00