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QT dispersion in patients with systemic lupus erythematosus: the impact of disease activity.

Abstract：

BACKGROUND:Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogeneity of cardiac repolarization and autonomic function. We compared the increase in QT dispersion in SLE patients with high disease activity and mild or moderate disease activity. METHODS AND RESULTS:One hundred twenty-four patients with SLE were enrolled in the study. Complete history and physical exam, ECG, echocardiography, exercise test and SLE disease activity index (SLEDAI) were recorded. Twenty patients were excluded on the basis of our exclusion criteria. The patients were divided to two groups based on SLEDAI: 54 in the high-score group (SLEDAI > 10) and 50 in the low-score group (SLEDAI < 10).QT dispersion was significantly higher in high-score group (58.31 ± 18.66 vs. 47.90 ± 17.41 respectively; P < 0.004). QT dispersion was not significantly higher in patients who had received hydroxychloroquine (54.17 ± 19.36 vs. 50.82 ± 15.96, P = 0.45) or corticosteroids (53.58 ± 19.16 vs. 50.40 + 11.59, P = 0.47). There was a statistically significant correlation between abnormal echocardiographic findings (abnormalities of pericardial effusion, pericarditis, pulmonary hypertension and Libman-Sacks endocarditis) and SLEADI (P < 0.004). CONCLUSIONS:QT dispersion can be a useful, simple noninvasive method for the early detection of cardiac involvement in SLE patients with active disease. Concerning high chance of cardiac involvement, cardiovascular evaluation for every SLE patient with a SLEDAI higher than 10 may be recommended. TRIAL REGISTRATION:Clinicaltrial.gov registration NCT01031797.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Kojuri J,Nazarinia MA,Ghahartars M,Mahmoody Y,Rezaian Gr,Liaghat L

doi

10.1186/1471-2261-12-11

subject

Has Abstract

pub_date

2012-02-27 00:00:00

pages

issn

1471-2261

pii

1471-2261-12-11

journal_volume

pub_type

临床试验,杂志文章

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QT dispersion in patients with systemic lupus erythematosus: the impact of disease activity.