Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis.

Abstract:

BACKGROUND:The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM). METHODS:We conducted a comprehensive search for controlled studies that evaluated the efficacy and safety of MRAs in patients with DM and HF. Medline, Embase and Cochrane databases were searched. Two reviewers independently identified citations, extracted data and evaluated quality. Risk estimations were abstracted and pooled where appropriate. RESULTS:Four observational studies were included. MRAs use was associated with reduced mortality compared with controls (RR = 0.78; 95% CI: 0.69-0.88; I(2) = 0%; P < 0.001). Increased risk of developing hyperkalaemia was observed in those patients taking MRAs (RR = 1.74; 95% CI: 1.27-2.38; I(2) = 0%; P = 0.0005). CONCLUSIONS:The current cumulative evidence suggests that MRAs can improve clinical outcomes but increase the risk of hyperkalaemia in patients with DM and HF. TRIAL REGISTRATION:PROSPERO CRD42015025690 .

journal_name

BMC Cardiovasc Disord

authors

Chen MD,Dong SS,Cai NY,Fan MD,Gu SP,Zheng JJ,Yin HM,Zhou XH,Wang LX,Li CY,Zheng C

doi

10.1186/s12872-016-0198-2

subject

Has Abstract

pub_date

2016-01-29 00:00:00

pages

28

issn

1471-2261

pii

10.1186/s12872-016-0198-2

journal_volume

16

pub_type

杂志文章,meta分析,评审
  • Cost-utility of enoxaparin compared with unfractionated heparin in unstable coronary artery disease.

    abstract:BACKGROUND:Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin licensed in the UK for use in unstable coronary artery disease (unstable stable angina and non-Q wave myocardial infarction). In these patients, two large ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2261-1-2

    authors: Nicholson T,McGuire A,Milne R

    更新日期:2001-01-01 00:00:00

  • A moderate 500-m treadmill walk for estimating peak oxygen uptake in men with NYHA class I-II heart failure and reduced left ventricular ejection fraction.

    abstract:BACKGROUND:Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus,...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0801-9

    authors: Mazzoni G,Sassone B,Pasanisi G,Myers J,Mandini S,Volpato S,Conconi F,Chiaranda G,Grazzi G

    更新日期:2018-04-16 00:00:00

  • ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model.

    abstract:BACKGROUND:We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril. METHODS:Thickening of the a...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-9-10

    authors: Simolin MA,Pedersen TX,Bro S,Mäyränpää MI,Helske S,Nielsen LB,Kovanen PT

    更新日期:2009-03-03 00:00:00

  • Medium-term outcomes of 78,808 patients after heart valve surgery in a middle-income country: a nationwide population-based study.

    abstract:BACKGROUND:Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival. METHODS:This was a retrospective study of 78,806 patients who underwent heart valve surgery be...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0725-9

    authors: de Aquino Xavier RM,Azevedo VMP,Godoy PH,Migowski A,Ribeiro ALP,Chaves RBM,Correia MG,de Aquino Xavier C,de Aquino Hashimoto L,Weksler C,Silva NASE

    更新日期:2017-12-28 00:00:00

  • Auscultatory versus oscillometric blood pressure measurement in patients with atrial fibrillation and arterial hypertension.

    abstract:BACKGROUND:The aim of our study was to investigate the reliability of automated oscillometric blood pressure (BP) monitoring in the presence and absence of atrial fibrillation (AF) in hypertensive patients. METHODS:BP was measured and compared in 71 randomly selected patients with AF and arterial hypertension diagnosi...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0521-6

    authors: Šelmytė-Besusparė A,Barysienė J,Petrikonytė D,Aidietis A,Marinskis G,Laucevičius A

    更新日期:2017-03-23 00:00:00

  • Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart.

    abstract:BACKGROUND:Ectonucleotidase plays an important role in the regulation of cardiac function by controlling extracellular levels of adenine nucleotides and adenosine. To determine the influence of ischemia-reperfusion injury on ectonucleotidase activity in coronary vascular bed, we compared the metabolic profile of adenin...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-13-53

    authors: Takahashi-Sato K,Murakawa M,Kimura J,Ito MA,Matsuoka I

    更新日期:2013-07-28 00:00:00

  • Aortic stenosis and mitral regurgitation as predictors of atrial fibrillation during 11 years of follow-up.

    abstract:BACKGROUND:There is limited information about any association between the onset of atrial fibrillation (AF) and the presence of valvular disease. METHODS:We retrospectively examined 940 patients in sinus rhythm, examined by echocardiography in 1996. During 11 years of follow-up, we assessed the incidence of AF and out...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-12-92

    authors: Widgren V,Dencker M,Juhlin T,Platonov P,Willenheimer R

    更新日期:2012-10-18 00:00:00

  • Early changes in ambulatory electrocardiography after transcatheter closure in patients with atrial septal defect and factors affecting heart rate variability.

    abstract:BACKGROUND:Factors affecting heart rate variability (HRV) in patients with atrial septal defect (ASD) have not been clarified. This study sought to identify those factors and establish a preliminary risk model. METHODS:A total of 154 patients with ASD who underwent transcatheter closure and met the study requirements ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01699-4

    authors: Su Z,Cao Q,Zhang H,Sun W,Zhang H,Sheng Y,Yang R,Kong X

    更新日期:2020-09-11 00:00:00

  • The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study.

    abstract:BACKGROUND:The simultaneous occurrence of cardiovascular disease (CVD), kidney disease, and anaemia is associated with increased morbidity and mortality. In the community setting, little data exists about the risk associated with milder levels of anaemia when it is present concurrently with CVD and chronic kidney disea...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-9-51

    authors: Anderson J,Glynn LG,Newell J,Iglesias AA,Reddan D,Murphy AW

    更新日期:2009-11-12 00:00:00

  • High platelet reactivity affects the clinical outcomes of patients undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:The association of platelet reactivity and clinical outcomes, especially stent thrombosis, was not so clear. We sought to investigate whether high platelet reactivity affects clinical outcomes of patients with drug eluting stents (DESs) implantation. METHODS:All enrolled individuals treated with DESs implan...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0394-0

    authors: Zhang JJ,Gao XF,Ge Z,Tian NL,Liu ZZ,Lin S,Ye F,Chen SL

    更新日期:2016-11-29 00:00:00

  • JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs.

    abstract:BACKGROUND:Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the accumulation of hepatic TG. The purpose of this study was to evaluate whether J...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-5-30

    authors: Aggarwal D,West KL,Zern TL,Shrestha S,Vergara-Jimenez M,Fernandez ML

    更新日期:2005-09-27 00:00:00

  • Elevated expression of periostin in diabetic cardiomyopathy and the effect of valsartan.

    abstract:BACKGROUND:Periostin, an extracellular matrix protein, plays a significant role in adverse cardiac remodeling. However, no report has documented the function of periostin in left ventricular remodeling of streptozototin (STZ)-induced diabetic rats. The aim of the present study was to observe the expression of periostin...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-015-0084-3

    authors: Guan J,Liu WQ,Xing MQ,Shi Y,Tan XY,Jiang CQ,Dai HY

    更新日期:2015-08-18 00:00:00

  • Aeroembolism in left atrium during catheter ablation of atrial fibrillation in a patient with dextrocardia: a case report and review of the literature.

    abstract:BACKGROUND:Air embolus penetrating into heart chamber as a complication during percutaneous radiofrequency catheter ablation has been infrequently reported. CASE PRESENTATION:A 55-year-old man with dextrocardia who suffered from abdominal pain was suspected to have multiple arterial thromboembolisms, which might have ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,评审

    doi:10.1186/s12872-017-0581-7

    authors: Wang YF,Cen XJ,Yu JW,Qu BM,Wang LH

    更新日期:2017-06-02 00:00:00

  • Prognostic significance of factor XIIIA promoter methylation status in aneurysmal subarachnoid haemorrhage (aSAH).

    abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage is a life- threatening condition with high rate of disability and mortality. Apolipoprotein E (APOE) and Factor XIIIA (F13A) genes are involved in the pathogenetic mechanism of aneurysmal subarachnoid haemorrhage (aSAH). We evaluated the association of promoter methylation ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-1146-8

    authors: Arati S,Chetan GK,Sibin MK,Bhat DI,Vazhayil V,Narasingarao KVL

    更新日期:2019-07-17 00:00:00

  • Deep vein thrombosis due to May-Thurner syndrome: a case report.

    abstract:BACKGROUND:May-Thurner syndrome (MTS) or Cockett's syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications of MTS include deep vein thrombus formation and even life-threatening pulmonary embolism. CASE PRE...

    journal_title:BMC cardiovascular disorders

    pub_type:

    doi:10.1186/s12872-020-01515-z

    authors: Meng Y,Qin H,Ma Q,Zhang J,Zhang B,Pang H,Yin Q,Tian H

    更新日期:2020-05-19 00:00:00

  • QT dispersion in patients with systemic lupus erythematosus: the impact of disease activity.

    abstract:BACKGROUND:Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogen...

    journal_title:BMC cardiovascular disorders

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2261-12-11

    authors: Kojuri J,Nazarinia MA,Ghahartars M,Mahmoody Y,Rezaian Gr,Liaghat L

    更新日期:2012-02-27 00:00:00

  • Evaluation of β-blocker therapy for long-term outcomes in patients with low ejection fraction after cardiac surgery.

    abstract:BACKGROUND:Preoperative low left ventricular ejection fraction (LVEF) has been reported as an independent risk factor for in-hospital mortality. However, there were few studies evaluating the long-term mortality in these patients. We, therefore, conducted this study to investigate long-term outcomes of surgery on patie...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01651-6

    authors: Fan FD,Zhang HT,Pan T,Tang XL,Wang DJ

    更新日期:2020-08-20 00:00:00

  • Do gender differences in primary PCI mortality represent a different adherence to guideline recommended therapy? a multicenter observation.

    abstract:BACKGROUND:It is uncertain whether gender differences in outcome after primary percutaneous coronary intervention (PCI) are only attributable to different baseline characteristics or additional factors. METHODS:Databases of two German myocardial infarction network registries were combined with a total of 1104 consecut...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2261-14-71

    authors: Birkemeyer R,Schneider H,Rillig A,Ebeling J,Akin I,Kische S,Paranskaya L,Jung W,Ince H,Nienaber CA

    更新日期:2014-06-02 00:00:00

  • Profile and predictor of health-related quality of life among hypertensive patients in south-western Nigeria.

    abstract:BACKGROUND:The health-related quality of life (HRQOL) of hypertensives may be influenced by blood pressure, adverse effects of drugs used to treat hypertension, or other factors, such as the labelling effect, or beliefs and attitudes about illness and treatment. There is paucity of information on the determinants of HR...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-9-25

    authors: Ogunlana MO,Adedokun B,Dairo MD,Odunaiya NA

    更新日期:2009-06-17 00:00:00

  • Endurance training or beta-blockade can partially block the energy metabolism remodeling taking place in experimental chronic left ventricle volume overload.

    abstract:BACKGROUND:Patients with chronic aortic valve regurgitation (AR) causing left ventricular (LV) volume overload can remain asymptomatic for many years despite having a severely dilated heart. The sudden development of heart failure is not well understood but alterations of myocardial energy metabolism may be contributiv...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-14-190

    authors: Lachance D,Dhahri W,Drolet MC,Roussel É,Gascon S,Sarrhini O,Rousseau JA,Lecomte R,Arsenault M,Couet J

    更新日期:2014-12-17 00:00:00

  • The relationship between mitral annular systolic velocity and ejection fraction in patients with preserved global systolic function of the left ventricle.

    abstract:BACKGROUND:The aim of the study was to investigate the relationship between the ejection fraction (EF) and the mitral annular systolic velocity (Sm) in patients with preserved left ventricular systolic function (EF>55%). The study task was to evaluate whether the assessment of Sm(avg) can be used as an alternative to t...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2261-13-92

    authors: Daskalov IR,Daskalova IK,Demirevska LD,Atzev BG

    更新日期:2013-10-26 00:00:00

  • Pathological interactions between the endothelin-1 and the angiotensin- converting enzyme among Tunisian coronary patients.

    abstract:BACKGROUND:The correct understanding of the biochemical and metabolic interactions between coronary risk factors contribute to the exploration of cardiovascular pathophysiology and improves therapeutic care. The aim of this study was to explore the endothelin-1 (ET-1) concentration and the angiotensin converting enzyme...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0417-x

    authors: Chalghoum A,Noichri Y,Dandana A,Baudin B,Miled A,Ferchichi S

    更新日期:2016-11-29 00:00:00

  • Impact of clinical presentation and presence of coronary sclerosis on long-term outcome of patients with non-obstructive coronary artery disease.

    abstract:BACKGROUND:Non-obstructive coronary artery disease (NOCAD) is a common finding on coronary angiography. Our goal was to evaluate the long-term prognosis of NOCAD patients with stable angina (SA). METHODS:The study cohort consisted of 7478 NOCAD patients with normal EF (≥ 50%), and SA who underwent coronary angiography...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0908-z

    authors: Kissel CK,Chen G,Southern DA,Galbraith PD,Anderson TJ,APPROACH investigators.

    更新日期:2018-08-22 00:00:00

  • Point of care platelet activity measurement in primary PCI [PINPOINT-PPCI]: a protocol paper.

    abstract:BACKGROUND:Optimal treatment of acute ST-elevation myocardial infarction (STEMI) involves rapid diagnosis, and transfer to a cardiac centre capable of percutaneous coronary intervention (PCI) for immediate mechanical revascularisation. Successful treatment requires rapid return of perfusion to the myocardium achieved b...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-14-44

    authors: Johnson TW,Marsden D,Mumford A,Pike K,Mundell S,Butler M,Strange JW,Bowles R,Rogers C,Baumbach A,Reeves BC

    更新日期:2014-04-04 00:00:00

  • Rheumatic mitral stenosis in children: more accelerated course in sub-Saharan patients.

    abstract:BACKGROUND:Mitral stenosis, one of the grave consequences of rheumatic heart disease, was generally considered to take decades to evolve. However, several studies from the developing countries have shown that mitral stenosis follows a different course from that seen in the developed countries. This study reports the pr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-13-95

    authors: Tadele H,Mekonnen W,Tefera E

    更新日期:2013-11-01 00:00:00

  • In vitro and clinical studies examining the expression of osteopontin in cigarette smoke-exposed endothelial cells and cigarette smokers.

    abstract:BACKGROUND:Cigarette smoking is a leading cause of mortality and morbidity and is associated with cardiovascular disease via contributory processes such as endothelial dysfunction, inflammation and thrombosis. Cigarette smoke both contains and stimulates the production of cellular oxidants and it may also promote vascu...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2261-12-75

    authors: Bishop E,Theophilus EH,Fearon IM

    更新日期:2012-09-17 00:00:00

  • Dynamic changes of paraoxonase 1 activity towards paroxon and phenyl acetate during coronary artery surgery.

    abstract:BACKGROUND:Serum paraoxonase 1 (PON1), an enzyme associated with high - density lipoproteins (HDL) particles, inhibits the oxidation of serum lipoproteins and cell membranes. PON1 activity is lower in patients with atherosclerosis and in inflammatory diseases. The systemic inflammatory response provoked during cardiopu...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0528-z

    authors: Wysocka A,Cybulski M,Berbeć H,Wysokiński A,Stążka J,Daniluk J,Zapolski T

    更新日期:2017-04-04 00:00:00

  • High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience.

    abstract:BACKGROUND:Systemic inflammation is an important feature of post-cardiac arrest syndrome (PCAS). This study was designed to determine whether the plasma concentrations of some circulating pro-inflammatory cytokines (interleukin-17 [IL-8], IL-22, IL-23 and IL-33) are of value in predicting the outcome of patients after ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01451-y

    authors: Zhuang YG,Chen YZ,Zhou SQ,Peng H,Chen YQ,Li DJ

    更新日期:2020-04-15 00:00:00

  • Phosphorylated proteomics analysis of human coronary artery endothelial cells stimulated by Kawasaki disease patients serum.

    abstract:BACKGROUND:Kawasaki disease (KD) is an acute febrile childhood systemic vasculitis that disturbs coronary arteries. The pathogenesis remains unknown. The study of phosphorylated proteins helps to elucidate the relevant pathophysiological mechanisms of cardiovascular disease. However, few researches explored phosphoryla...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0982-2

    authors: Li SM,Liu WT,Yang F,Yi QJ,Zhang S,Jia HL

    更新日期:2019-01-17 00:00:00

  • Outcome and quality of life after aorto-bifemoral bypass surgery.

    abstract:BACKGROUND:Aorto-bifemoral bypass (AFB) is commonly performed to treat aorto-iliac disease and a durable long-term outcome is achieved. Most studies documenting beneficial outcomes after AFB have been limited to mortality and morbidity rates, costs and length of hospital stay (LOS). Few studies have examined the depend...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-10-15

    authors: Abelha FJ,Botelho M,Fernandes V,Barros H

    更新日期:2010-03-18 00:00:00