Abstract:
BACKGROUND:Microvascular insufficiency plays an important role in the development of diabetic cardiomyopathy (DCM), therapeutic angiogenesis has been mainly used for the treatment of ischemic diseases. This study sought to verify the preclinical performance of SonoVue microbubbles (MB) combined ultrasound (US) treatment on myocardial angiogenesis in the rat model of DCM and investigate the optimal ultrasonic parameters. METHODS:The male Sprague-Dawley (SD) rats were induced DCM by streptozotocin through intraperitoneal injecting and fed with high-fat diet. After the DCM model was established, the rats were divided into the normal group, DCM model group, and US + MB group, while the US + MB group was divided into four subsets according to different pulse lengths (PL) (8 cycles;18 cycle;26 cycle; 36 cycle). After all interventions, all rats underwent conventional echocardiography to examine the cardiac function. The rats were sacrificed and myocardial tissue was examined by histology and morphometry evaluations to detect the myocardial protective effect of SonoVue MBs using US techniques. RESULTS:From morphologic observation and echocardiography, the DCM rats had a series of structural abnormalities of cardiac myocardium compared to the normal rats. The US-MB groups exerted cardioprotective effect in DCM rats, improved reparative neovascularization and increased cardiac perfusion, while the 26 cycle group showed significant therapeutic effects on the cardiac functions in DCM rats. CONCLUSION:This strategy using SonoVue MB and US can improve the efficacy of angiogenesis, even reverse the progress of cardiac dysfunction and pathological abnormalities, especially using the 26 cycle parameters. Under further study, this combined strategy might provide a novel approach for early intervention of DCM in diabetic patients.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Zhang X,Tian X,Li P,Zhu H,Zhou N,Fang Z,Yang Y,Jing Y,Yuan Jdoi
10.1186/s12872-020-01815-4subject
Has Abstractpub_date
2021-01-07 00:00:00pages
21issue
1issn
1471-2261pii
10.1186/s12872-020-01815-4journal_volume
21pub_type
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,meta分析,评审
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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