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Adipo/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque.

Abstract：

BACKGROUND:Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery. METHODS:We evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16). RESULTS:We found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects. CONCLUSIONS:Of all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.

journal_name

BMC Cardiovasc Disord

journal_title

BMC cardiovascular disorders

authors

Auguet T,Aragonès G,Guiu-Jurado E,Berlanga A,Curriu M,Martinez S,Alibalic A,Aguilar C,Camara ML,Hernández E,Ruyra X,Martín-Paredero V,Richart C

doi

10.1186/s12872-016-0320-5

subject

Has Abstract

pub_date

2016-07-08 00:00:00

pages

149

issue

1

issn

1471-2261

pii

10.1186/s12872-016-0320-5

journal_volume

16

pub_type

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