Abstract:
BACKGROUND:We performed a systematic review and meta-analysis of the Matrix metalloproteinases (MMP)-9 (C1562T), MMP-9 (R279Q), MMP-9 (P574R) and MMP-9 (R668Q) polymorphisms and risk of Coronary Artery Disease (CAD). METHODS:After a systematic literature search, pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were used to evaluate the strength of the association. RESULTS:We identified 40 studies with 11,792 cases and 8280 controls for C1562T, 7 case-control studies with 5525 cases and 2497 controls for R279Q, 2 studies with 1272 cases and 785 controls for P574R, and 2 studies with 1272 cases and 785 controls for R668Q. MMP-9 (C1562T) polymorphism was associated with increased risk of CAD under dominant model (OR = 1.41, P < 0.001), recessive model (OR = 1.59, P < 0.001), allelic model (OR = 1.38, P < 0.001), TT vs. CC model (OR = 1.70, P < 0.001), and CT vs. CC model (OR = 1.35, P < 0.001). Moreover, the subgroup analysis based on the continent of the study populations in this SNP indicated strong significant association in Asians but not in Europeans. Subgroup analysis was not performed in Africa, America and Oceania, due to lack of sufficient data. CONCLUSIONS:Our meta-analysis revealed that MMP-9 (C1562T) SNP conferred a susceptibility risk for CAD in the overall analysis and Asian population. The overall analysis and subgroup analysis of the other three SNPs reject the association between MMP-9 polymorphisms and the risk of CAD. Although the results should interpret with caution because of small sample size of included studies in these three SNPs.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Hassanzadeh-Makoui R,Razi B,Aslani S,Imani D,Tabaee SSdoi
10.1186/s12872-020-01510-4subject
Has Abstractpub_date
2020-05-19 00:00:00pages
232issue
1issn
1471-2261pii
10.1186/s12872-020-01510-4journal_volume
20pub_type
杂志文章,meta分析abstract:BACKGROUND:Microvascular insufficiency plays an important role in the development of diabetic cardiomyopathy (DCM), therapeutic angiogenesis has been mainly used for the treatment of ischemic diseases. This study sought to verify the preclinical performance of SonoVue microbubbles (MB) combined ultrasound (US) treatmen...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
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更新日期:2016-02-06 00:00:00
abstract:BACKGROUND:Areca nut (commonly known as betel nut) chewing has been shown to be associated with metabolic syndrome and cardiovascular disease (CVD). The mechanism by which betel nut ingestion could lead to development of CVD is not precisely known; however, dyslipidemia, hyperhomocysteinemia, hypertriglyceridemia and i...
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更新日期:2012-11-28 00:00:00
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journal_title:BMC cardiovascular disorders
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更新日期:2015-06-10 00:00:00
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更新日期:2020-12-01 00:00:00
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doi:10.1186/1471-2261-12-92
更新日期:2012-10-18 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/1471-2261-12-46
更新日期:2012-06-24 00:00:00
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更新日期:2019-08-02 00:00:00
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doi:10.1186/s12872-017-0575-5
更新日期:2017-05-30 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/s12872-018-0764-x
更新日期:2018-02-07 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-22
更新日期:2012-03-30 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,meta分析
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更新日期:2021-01-06 00:00:00
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更新日期:2019-12-30 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-07-27 00:00:00
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journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-30 00:00:00
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更新日期:2017-04-04 00:00:00
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更新日期:2016-08-22 00:00:00
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