Abstract：
BACKGROUND:The association of elevated serum levels of secretory phospholipase A2 (sPLA2) in patients with cardiovascular disease and their presence in atherosclerotic lesions suggest the participation of sPLA2 enzymes in this disease. The presence of more advanced atherosclerotic lesions in mice that overexpress sPLA2 enzymes suggest their involvement in the atherosclerotic process. Therefore, the sPLA2 family of enzymes could provide reasonable targets for the prevention and treatment of atherosclerosis. Thus, A-002 (varespladib), an inhibitor of sPLA2enzymes, is proposed to modulate the development of atherosclerosis. METHODS:Twenty-four guinea pigs were fed a high saturated fat, high cholesterol diet (0.25%) for twelve weeks. Animals were treated daily with A-002 (n = 12) or vehicle (10% aqueous acacia; n = 12) by oral gavage. After twelve weeks, animals were sacrificed and plasma, heart and aorta were collected. Plasma lipids were measured by enzymatic methods, lipoprotein particles size by nuclear magnetic resonance, aortic cytokines by a colorimetric method, and aortic sinus by histological analyses. RESULTS:Plasma total cholesterol, HDL cholesterol and triglycerides were not different among groups. However, the levels of inflammatory cytokines interleukin (IL)-10, IL-12 and granulocyte-macrophage colony-stimulating factor (GM-CSF) were significantly reduced in the treatment group. This group also had a significant 27% reduction in cholesterol accumulation in aorta compared with placebo group. Morphological analysis of aortic sinus revealed that the group treated with A-002 reduced atherosclerotic lesions by 24%. CONCLUSION:The use of A-002 may have a beneficial effect in preventing diet-induced atherosclerosis in guinea pigs.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Leite JO,Vaishnav U,Puglisi M,Fraser H,Trias J,Fernandez MLdoi
10.1186/1471-2261-9-7subject
Has Abstractpub_date
2009-02-17 00:00:00pages
7issn
1471-2261pii
1471-2261-9-7journal_volume
9pub_type
杂志文章abstract：BACKGROUND:The aim of this study was to assess significance of serum neutrophil gelatinase-associated lipocalin (sNGAL) and cystatin C (sCC) in prediction of adverse cardiovascular outcome after ST-segment elevation myocardial infarction (STEMI). METHODS:We recruited 357 consecutive patients who were admitted to the h...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0514-5
更新日期：2017-03-15 00:00:00
abstract：BACKGROUND:The aim of the study was to investigate the relationship between the ejection fraction (EF) and the mitral annular systolic velocity (Sm) in patients with preserved left ventricular systolic function (EF>55%). The study task was to evaluate whether the assessment of Sm(avg) can be used as an alternative to t...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2261-13-92
更新日期：2013-10-26 00:00:00
abstract：BACKGROUND:Studies regarding the association between prehypertension and the structual changes of left heart are scanty. However, which type of the geometrical change of left heart is predominated one in prehypertension and hypertension is controversial. It is therefore important to investigate geometrical and function...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0286-3
更新日期：2016-05-28 00:00:00
abstract：BACKGROUND:Atherosclerosis (AT) is a chronic inflammatory disease characterized by the accumulation of inflammatory cells, lipoproteins and fibrous tissue in the walls of arteries. AT is the primary cause of heart attacks and stroke and is the leading cause of death in Western countries. To date, the pathogenesis of AT...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-13-4
更新日期：2013-01-16 00:00:00
abstract：BACKGROUND:Cigarette exposure increases brain oxidative stress. The literature showed that increased brain oxidative stress affects cardiovascular regulation. However, no previous study investigated the involvement of brain oxidative stress in animals exposed to cigarette and its relationship with cardiovascular regula...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-12-22
更新日期：2012-03-30 00:00:00
abstract：BACKGROUND:Left ventricle mass (LVM) can be influenced by various conditions including hypertension and/or inherent cardiomyopathies. Dysglycemia is also thought to exert an anabolic effect on heart tissue by hyperinsulinemia and thereby promoting increased LVM. The primary aim of this study was to assess the influence...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1084-5
更新日期：2019-05-02 00:00:00
abstract：BACKGROUND:Left ventricular (LV) rotation is increasingly examined in those with heart disease. The available evidence measuring LV rotation in those with heart diseases has not been systematically reviewed. METHODS:To review systematically the evidence measuring LV rotational changes in various heart diseases compare...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,评审
doi：10.1186/1471-2261-12-46
更新日期：2012-06-24 00:00:00
abstract：BACKGROUND:The patient self-management (PSM) is an effective approach for controlling the international normalized ratio, INR, within the therapeutic range. Nevertheless, most of the literature derives from randomized clinical trials, and no from routine clinical practice. The main objective of the present study was to...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1168-2
更新日期：2019-08-02 00:00:00
abstract：BACKGROUND:An unusual case of typical angina which occurred on a long haul flight is presented. This case is notable as this was the index presentation, with no previous symptoms prior to this. Physiological changes at altitude can be marked, and include hypoxia, tachycardia and an increase in cardiac output. These cha...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0797-1
更新日期：2018-04-05 00:00:00
abstract：BACKGROUND:The aim of this study was to assess among pacemaker patients their overall satisfaction with the pacemaker system, pain, soreness/discomfort, cosmetic results, restrictions due to impaired movement of the shoulder/arm/chest, related sleep disturbances, and concern about possible device malfunction. METHODS:...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0849-6
更新日期：2018-06-04 00:00:00
abstract：BACKGROUND:Heart failure is a major and growing medical and economic problem worldwide as 1-2% of the healthcare budget are spent for heart failure. The prevalence of heart failure has increased over the past decades and it is expected that there will be further raise due to the higher proportion of elderly in the west...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0815-3
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:Cardiovascular diseases (CVDs) are one of the leading causes of death and disability in the world. Over 80% of CVD deaths take place in low-and middle-income countries. One-third of the population aged above 40 years suffers from Hypertension (HTN) and this is largely unreported as there is no registry for C...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/1471-2261-13-76
更新日期：2013-09-25 00:00:00
abstract：BACKGROUND:Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients. The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle. Treatment of cardiomyocyte membrane instability could help prevent cardiomyopathy. METHODS:Three month ol...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-11-20
更新日期：2011-05-16 00:00:00
abstract：BACKGROUND:There have been suggestions of an association between Chlamydia pneumoniae, chlamydial heat shock protein (Ch-hsp) 60 and human heat shock protein (h-hsp) 60 infection sero-status and development of secondary cardiovascular events. Patients with diabetes might be at higher risk since they are prone to infect...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-6-17
更新日期：2006-04-12 00:00:00
abstract：BACKGROUND:The usefulness of the CHA2DS2-VASC risk score (CVRS) in predicting the occurrence of contrast-induced nephropathy (CIN) among patients with chronic total occlusion (CTO) undergoing percutaneous coronary intervention (PCI) remains unclear. METHOD:A total of 239 patients with CTO who underwent PCI were includ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1060-0
更新日期：2019-03-29 00:00:00
abstract：BACKGROUND:Air embolus penetrating into heart chamber as a complication during percutaneous radiofrequency catheter ablation has been infrequently reported. CASE PRESENTATION:A 55-year-old man with dextrocardia who suffered from abdominal pain was suspected to have multiple arterial thromboembolisms, which might have ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,评审
doi：10.1186/s12872-017-0581-7
更新日期：2017-06-02 00:00:00
abstract：BACKGROUND:There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated. METHODS:Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationsh...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-019-1236-7
更新日期：2019-11-07 00:00:00
abstract：BACKGROUND:Idiopathic ventricular tachycardia (VT) and/or premature ventricular contractions (PVCs) arise most commonly from the right ventricular outflow tract and less frequently from the left ventricular outflow tract (LVOT), either below or above the semilunar valves. CASE PRESENTATION:We report a case of 24-year-...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-14-161
更新日期：2014-11-18 00:00:00
abstract：BACKGROUND:We investigated the association between heart rate and its variability with the parameters that assess vascular, renal and cardiac target organ damage. METHODS:A cross-sectional study was performed including a consecutive sample of 360 hypertensive patients without heart rate lowering drugs (aged 56 ± 11 ye...
journal_title：BMC cardiovascular disorders
pub_type： 临床试验,杂志文章
doi：10.1186/1471-2261-12-19
更新日期：2012-03-22 00:00:00
abstract：BACKGROUND:The correct understanding of the biochemical and metabolic interactions between coronary risk factors contribute to the exploration of cardiovascular pathophysiology and improves therapeutic care. The aim of this study was to explore the endothelin-1 (ET-1) concentration and the angiotensin converting enzyme...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0417-x
更新日期：2016-11-29 00:00:00
abstract：BACKGROUND:Suspected nonischemic cardiomyopathy (NICM) is a common clinical setting with highly variable prognosis. Early noninvasive risk-stratification is important for justification of invasive examinations, specific treatment and patient surveillance. We studied the additional prognostic value of late gadolinium en...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-14-110
更新日期：2014-08-27 00:00:00
abstract：BACKGROUND:Although the benefits of supervised physical activity programs in cardiac rehabilitation have been well documented, the amount of physical activity often drops quickly after the end of the supervised period. This trial (registered as ISRCTN77313697 ) will evaluate the effectiveness of an experimental interve...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,随机对照试验
doi：10.1186/s12872-016-0325-0
更新日期：2016-08-22 00:00:00
abstract：BACKGROUND:Increasing rates of percutaneous coronary intervention (PCI) and decreasing rates of coronary artery bypass graft (CABG) surgery followed the introduction of drug eluting stents in Western Australia in 2002. We assessed the impact of these changes on one-year outcomes for the total population of patients und...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2261-13-47
更新日期：2013-07-05 00:00:00
abstract：BACKGROUND:Cardiac Rehabilitation (CR) and secondary prevention are effective components of evidence-based management for cardiac patients, resulting in improved clinical and behavioural outcomes. Mobile health (mHealth) is a rapidly growing health delivery method that has the potential to enhance CR and heart failure ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,评审
doi：10.1186/s12872-018-0764-x
更新日期：2018-02-07 00:00:00
abstract：BACKGROUND:Provisional 1-stent technique is currently regarded as the default approach for the majority of bifurcation lesions. Nonetheless, 2-stent techniques may be required for complex bifurcations with high compromise risk or fatal consequences of side branch (SB) occlusion. Limitations exist in current approaches,...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01605-y
更新日期：2020-07-07 00:00:00
abstract：BACKGROUND:Heart failure (HF) remains a significant cause of morbidity and mortality. Multiple trials over the past several years have examined the effects of both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) in the treatment of left ventricular dysfunction, both acutely ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-017-0686-z
更新日期：2017-10-05 00:00:00
abstract：BACKGROUND:Asprosin is a novel fasting glucogenic adipokine discovered in 2016. Asprosin induces rapid glucose releases from the liver. However, its molecular mechanisms and function are still unclear. Adaptation of energy substrates from fatty acid to glucose is recently considered a novel therapeutic target in heart ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01680-1
更新日期：2020-09-07 00:00:00
abstract：BACKGROUND:Studies adopting electronic medical records and genomic information are becoming widespread. Through this new modality in research, it is possible to study how genetic variants influence susceptibility towards chronic conditions and can improve patient care.Our aim is to develop a biobank with 2,000 heart fa...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-14-32
更新日期：2014-03-04 00:00:00
abstract：BACKGROUND:Renal function is an important predictor of mortality in patients with myocardial infarction (MI), but changes in the impact over time have not been well described.We examined the importance of renal function by estimated GFR (eGFR) and se-creatinine as an independent long-term prognostic factor. METHODS:Pr...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2261-11-37
更新日期：2011-06-27 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the difference in effects of beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those with reduced ejection fraction (rEF). METHODS:Data were assessed of 3508 consecutive IHD patients w...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-021-01850-9
更新日期：2021-01-15 00:00:00
