Abstract：
BACKGROUND:The correct understanding of the biochemical and metabolic interactions between coronary risk factors contribute to the exploration of cardiovascular pathophysiology and improves therapeutic care. The aim of this study was to explore the endothelin-1 (ET-1) concentration and the angiotensin converting enzyme (ACE) activity among Tunisian patients with coronary heart disease, and to investigate the metabolic relationships between these two markers,… and to assess the possible relationship between them and the different risk factors. In this present study, ET-1 concentration was determined by an analytical method (High Performance Chromatography, coupled by Mass Spectrometry), ACE activity was measured by a kinetic method for patients and healthy controls. These subjects (157 patients and 142 controls) beneficed also by a biochemical exploration (lipid, apolipoproteins and glucose profiles) to quantify cardiovascular risk. RESULTS:A statistically significant increase of the ET-1 concentration was found among patients compared to healthy controls (15.2 ± 5.3 nM vs 7.1 ± 2.7 nM, p < 0,00001). For the ACE activity, in spite the treatment of the majority of patients (97%) with ACE inhibitors, this activity was statistically elevated in patients compared to healthy subjects (86.7 ± 25.4 IU/L vs 42.8 ± 12.1 IU/L, p < 0.00001). Furthermore, a statistically positive correlation was identified between these two cardiac markers (r = 0.68 p < 0.00001). CONCLUSION:The study of the metabolic relationship between the ET-1 and ACE among coronary patients reveals other therapeutics targets.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Chalghoum A,Noichri Y,Dandana A,Baudin B,Miled A,Ferchichi Sdoi
10.1186/s12872-016-0417-xsubject
Has Abstractpub_date
2016-11-29 00:00:00pages
244issue
1issn
1471-2261pii
10.1186/s12872-016-0417-xjournal_volume
16pub_type
杂志文章abstract：BACKGROUND:The aim was to investigate the extent to which it is possible to diagnose suspected carotid calcification from dental panoramic radiography (PR) and to establish an association to periodontal risk. METHODS:824 PRs from one dental practice were investigated. Parameters considered were gender, age, bone loss ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-11-67
更新日期：2011-11-09 00:00:00
abstract：BACKGROUND:We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS:Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/s12872-019-1187-z
更新日期：2019-10-29 00:00:00
abstract：BACKGROUND:The increasing burden of cardiovascular diseases (CVD) in the ageing population of industrialized nations requires an intensive search for means of reducing this epidemic. In order to improve prevention, detection, therapy and prognosis of cardiovascular diseases on the population level in Eastern Germany, i...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-5-33
更新日期：2005-11-11 00:00:00
abstract：BACKGROUND:Patients requiring anticoagulation suffer from comorbidities such as hypertension. On the occasion of INR monitoring, general practitioners (GPs) have the opportunity to control for blood pressure (BP). We aimed to evaluate the impact of Vitamin-K Antagonist (VKA) monitoring by GPs on BP control in patients ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0053-x
更新日期：2015-06-10 00:00:00
abstract：BACKGROUND:Although drug-eluting stents have dramatically reduced the rates of restenosis and target lesion revascularization, they are associated with stent thrombosis (ST), a catastrophic event likely due to delayed endothelialization and chronic inflammation caused by the polymer and the metal scaffolds. To increase...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0654-7
更新日期：2017-08-15 00:00:00
abstract：BACKGROUND:Hyperlipidemia and hypertension are well-established risk factors for recurrent cardiovascular events among patients with ischemic heart disease (IHD). Despite national recommendations, concordance with guidelines for LDL cholesterol and blood pressure remains inadequate. The objectives of this study were to...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-6-6
更新日期：2006-02-09 00:00:00
abstract：BACKGROUND:Effects of β-blockers on outcomes in patients with chronic heart failure (CHF) and atrial fibrillation (AF) is still in controversy. METHODS:Searching was conducted by using keywords "atrial fibrillation", and "heart failure" in PubMed, MEDLINE and Embase databases before November 30, 2017. Prospective stud...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-019-1079-2
更新日期：2019-06-03 00:00:00
abstract：BACKGROUND:The incidence and mortality of cardiovascular diseases (CVDs) in low and middle income countries (LMICs) have been increasing, while access to CVDs medicines is suboptimal. We assessed selection of essential medicines for the prevention and treatment of CVDs on national essential medicines lists (NEMLs) of L...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0858-5
更新日期：2018-06-25 00:00:00
abstract：BACKGROUND:Prevention and early detection of arterial stiffness are required to avoid severe cardiovascular events. Recently, new noninvasive arterial stiffness indices, the arterial pressure volume index (API) and the arterial velocity pulse index (AVI), have been developed. The purpose of this study was to examine th...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0389-x
更新日期：2016-11-07 00:00:00
abstract：BACKGROUND:Elevated plasma triglycerides (TGs) are widely used as a major cardiovascular risk predictor and are thought to play an important role in the progression of coronary heart disease (CHD). It has been demonstrated that lipid lowering was associated with lower mortality in patients with CHD. The present study t...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-018-0965-3
更新日期：2019-01-03 00:00:00
abstract：BACKGROUND:Smoking is the most important reversible cardiovascular risk factor. It is well established that quitting smoking reduces coronary events. However, on several occasions, the cardiovascular safety of smoking cessation drugs has been questioned. Our goal is to evaluate the effects of smoking cessation drugs on...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0180-4
更新日期：2016-01-05 00:00:00
abstract：BACKGROUND:The 'My Experience of Taking Medicines' (MYMEDS) questionnaire is a self-reporting tool for identifying modifiable adherence barriers among individuals prescribed post-myocardial infarction (MI) secondary prevention medicines (SPM) in clinical practice. It was found to be a useful tool to support the conduct...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01362-y
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:Diabetes is one of the major risk factors for cardiomyopathy and heart failure with reduced ejection fraction (EF) and highly associated with left ventricular (LV) dysfunction in human. This study aimed 1) to noninvasively assess cardiac function using echocardiography; 2) to test the hypothesis that like di...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-015-0133-y
更新日期：2015-10-30 00:00:00
abstract：BACKGROUND:We investigated the association between heart rate and its variability with the parameters that assess vascular, renal and cardiac target organ damage. METHODS:A cross-sectional study was performed including a consecutive sample of 360 hypertensive patients without heart rate lowering drugs (aged 56 ± 11 ye...
journal_title：BMC cardiovascular disorders
pub_type： 临床试验,杂志文章
doi：10.1186/1471-2261-12-19
更新日期：2012-03-22 00:00:00
abstract：BACKGROUND:Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury. This study aims to evaluate the risk of atherosclerosis induced by RDN in renal arteries. METHODS:A total of 15 minipigs w...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01472-7
更新日期：2020-04-16 00:00:00
abstract：BACKGROUND:Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence of these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) and within thrombi adjacent to ruptures has not been described, nor an association with iro...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-9-27
更新日期：2009-06-23 00:00:00
abstract：BACKGROUND:Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival. METHODS:This was a retrospective study of 78,806 patients who underwent heart valve surgery be...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0725-9
更新日期：2017-12-28 00:00:00
abstract：BACKGROUND:Adverse effects, treatment resistance and high costs associated with pharmacological treatment of hypertension have led to growing interest in non-pharmacological complementary therapies such as music interventions. This meta-analysis aims to provide an overview of reported evidence on the efficacy of music ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12872-016-0244-0
更新日期：2016-04-19 00:00:00
abstract：BACKGROUND:Ventricular arrhythmias (VAs) originating from the left ventricular summit is a challenge for radiofrequency catheter ablation (RFCA). The present study aimed to investigate the appropriate RFCA strategy for VAs originating from the left ventricular summit. METHODS:Forty-five consecutive patients with VAs a...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-017-0575-5
更新日期：2017-05-30 00:00:00
abstract：BACKGROUND:The significant reduction of angiographic restenosis rates in the ISAR-SWEET study (intracoronary stenting and antithrombotic regimen: is abciximab a superior way to eliminate elevated thrombotic risk in diabetes) raises the question of whether abciximab acts on clopidogrel-independent mechanisms in suppress...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/1471-2261-6-14
更新日期：2006-04-04 00:00:00
abstract：BACKGROUND:N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to investigate the minimal informative monitoring interval of NT-proBNP in patients with stable chroni...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01537-7
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:This study aimed at investigating the CV health and CV disease knowledge in terms of LS7 score among 3 age groups in Hong Kong. METHODS:A cross-sectional multicenter observational study was conducted to observe the CV health and disease risk knowledge in Hong Kong. Elderly subjects were recruited from 15 el...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究
doi：10.1186/s12872-019-1171-7
更新日期：2019-08-02 00:00:00
abstract：BACKGROUND:Inflammatory cells infiltrate into the ischemic and hypoxic myocardial tissue after myocardial infarction. B cells gather at the site of myocardial injury and secrete cytokines to regulate immune inflammation and fiber repair processes. METHODS:The animal experiment used ligation of the left anterior descen...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01775-9
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-020-01491-4
更新日期：2020-05-18 00:00:00
abstract：BACKGROUND:Cardiac rehabilitation (CR) programs provide significant benefit for people with cardiovascular disease. Despite these benefits, such services are not universally available. We designed and evaluated a national home-based CR (HBCR) program in the Veterans Health Administration (VHA). The primary aim of the s...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-019-1224-y
更新日期：2019-11-06 00:00:00
abstract：BACKGROUND:The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate w...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-015-0044-y
更新日期：2015-06-26 00:00:00
abstract：BACKGROUND:The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk individuals. The aim of this meta-analysis was to assess the efficacy of allopurinol treatment in red...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析
doi：10.1186/s12872-018-0881-6
更新日期：2018-07-11 00:00:00
abstract：BACKGROUND:Several meta-analyses have indicated that periodontal disease (PD) are related to cardiovascular diseases (CVDs). However, the association between PD and myocardial infarction (MI) remains controversial. Here we aimed to assess the association between PD and MI by meta-analysis of observational studies. MET...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1186/s12872-017-0480-y
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:In heart failure (HF) patients with implantable cardioverter defibrillators (ICD) or cardiac resynchronisation therapy defibrillators (CRT-D), remote monitoring has been shown to result in at least non-inferior outcomes relative to in-clinic visits. We aimed to provide further evidence for this effect, and t...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1186/s12872-018-0864-7
更新日期：2018-06-28 00:00:00
abstract：BACKGROUND:Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimetazidine could favorably affect this process also needs to be determined. The aim of the study was to ...
journal_title：BMC cardiovascular disorders
pub_type： 杂志文章
doi：10.1186/s12872-016-0399-8
更新日期：2016-11-17 00:00:00
