Abstract:
BACKGROUND:The significant reduction of angiographic restenosis rates in the ISAR-SWEET study (intracoronary stenting and antithrombotic regimen: is abciximab a superior way to eliminate elevated thrombotic risk in diabetes) raises the question of whether abciximab acts on clopidogrel-independent mechanisms in suppressing neointimal hyperplasia. The current study investigates the direct effect of abciximab on ICAM-1 expression, migration and proliferation. METHODS:ICAM-1: Part I of the study investigates in cytoflow studies the effect of abciximab (0.0002, 0.002, 0.02, 0.2, 2.0, and 20.0 microg/ml) on TNF-alpha induced expression of intercellular adhesion molecule 1 (ICAM-1). Migration: Part II of the study explored the effect of abciximab (0.0002, 0.002, 0.02, 0.2, 2.0, and 20.0 microg/ml) on migration of HCMSMC over a period of 24 h. Proliferation: Part III of the study investigated the effect of abciximab (0.0002, 0.002, 0.02, 0.2, 2.0, and 20.0 microg/ml) on proliferation of HUVEC, HCAEC, and HCMSMC after an incubation period of 5 days. RESULTS:ICAM-1: In human venous endothelial cells (HUVEC), human coronary endothelial cells (HCAEC) and human coronary medial smooth muscle cells (HCMSMC) no inhibitory or stimulatory effect on expression of ICAM-1 was detected. Migration: After incubation of HCMSMC with abciximab in concentrations of 0.0002-2 microg/ml a stimulatory effect on cell migration was detected, statistical significance was achieved after incubation with 0.002 microg/ml (p < 0.05), 0.002 microg/ml (p < 0.001), and 0.2 microg/ml (p < 0.05). Proliferation: Small but statistically significant antiproliferative effects of abciximab were detected after incubation of HUVEC (0.02 and 2.0 microg/ml; p = 0.01 and p < 0.01), HCAEC (2.0 and 20.0 microg/ml; p < 0.05 and p < 0,01), and HCMSMC (2.0 and 20.0 microg/ml; p < 0.05 and p < 0.05). The significant inhibition (SI) of cell proliferation found in HCAEC and HCMSMC was achieved with drug concentrations more than 10 times beyond the maximal plasma level (MPL), resulting in a SI/MPL-ratio > 1. CONCLUSION:Thus, the anti-restenotic effects of systemically administered abciximab reported in the ISAR-SWEET-study were not caused by a direct inhibitory effect on ICAM-1 expression, migration or proliferation.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Voisard R,Alan M,von Müller L,Baur R,Hombach Vdoi
10.1186/1471-2261-6-14subject
Has Abstractpub_date
2006-04-04 00:00:00pages
14issn
1471-2261pii
1471-2261-6-14journal_volume
6pub_type
杂志文章abstract:BACKGROUND:ST elevation Myocardial infarction is a medical emergency. A variety of noncardiac conditions had been known to mimic the ECG changes that are seen in acute coronary syndrome. Although the common ECG changes that are documented with raised intracranial pressure are T inversions, prolongation of QT interval a...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0525-2
更新日期:2017-04-04 00:00:00
abstract:BACKGROUND:Several meta-analyses have indicated that periodontal disease (PD) are related to cardiovascular diseases (CVDs). However, the association between PD and myocardial infarction (MI) remains controversial. Here we aimed to assess the association between PD and MI by meta-analysis of observational studies. MET...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-017-0480-y
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Swallow or deglutition syncope is an unusual type of neurally-mediated syncope associated with life-threatening bradyarrhythmia and hypotension. It is a difficult condition to diagnose with commonly delayed diagnosis and management. There is lack of review articles that elucidate the basic demographics, clin...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1174-4
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:The efficacy and safety of ambrisentan has been previously evaluated in Chinese patients with pulmonary arterial hypertension (PAH). This post-hoc analysis assessed the efficacy and safety of ambrisentan in a subgroup of connective tissue disease (CTD) patients with PAH. METHODS:In this open-label, single-a...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/s12872-020-01591-1
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:Elevated plasma triglycerides (TGs) are widely used as a major cardiovascular risk predictor and are thought to play an important role in the progression of coronary heart disease (CHD). It has been demonstrated that lipid lowering was associated with lower mortality in patients with CHD. The present study t...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0965-3
更新日期:2019-01-03 00:00:00
abstract:BACKGROUND:Idiopathic ventricular tachycardia (VT) and/or premature ventricular contractions (PVCs) arise most commonly from the right ventricular outflow tract and less frequently from the left ventricular outflow tract (LVOT), either below or above the semilunar valves. CASE PRESENTATION:We report a case of 24-year-...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-161
更新日期:2014-11-18 00:00:00
abstract:BACKGROUND:Diabetes is an important predictor of mortality patients with ACS. However, little is known about the association between diabetes and health status after ACS. The objective of this study was to examine the association between diabetes and patients' health status outcomes one year after an acute coronary syn...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-6-41
更新日期:2006-10-24 00:00:00
abstract:BACKGROUND:Cardiac rehabilitation (CR) programs provide significant benefit for people with cardiovascular disease. Despite these benefits, such services are not universally available. We designed and evaluated a national home-based CR (HBCR) program in the Veterans Health Administration (VHA). The primary aim of the s...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-019-1224-y
更新日期:2019-11-06 00:00:00
abstract:BACKGROUND:Heart failure (HF) is one of the most debilitating chronic illnesses. The prevalence is expected to increase due to aging population. The current study aimed to examine the management of heart failure with preserved ejection fraction (HFpEF) including drug use pattern, direct medical cost and humanistic outc...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0002-8
更新日期:2015-02-25 00:00:00
abstract:BACKGROUND:Increasing rates of percutaneous coronary intervention (PCI) and decreasing rates of coronary artery bypass graft (CABG) surgery followed the introduction of drug eluting stents in Western Australia in 2002. We assessed the impact of these changes on one-year outcomes for the total population of patients und...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2261-13-47
更新日期:2013-07-05 00:00:00
abstract:BACKGROUND:Ventricular strain measurements vary depending on cardiac chamber (left ventricle [LV] or right ventricle [RV]), type of strain (longitudinal, circumferential, or radial), ventricular level (basal, mid, or apical), myocardial layer (endocardial or epicardial), and software used for analysis, among other demo...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01559-1
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:To investigate the diagnostic value of dual-source computed tomography (DSCT) in the evaluation of tetralogy of Fallot (TOF)-associated extracardiac vascular abnormalities in pediatric patients compared with transthoracic echocardiography (TTE). METHODS:One hundred and twenty-three pediatric patients diagno...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-017-0718-8
更新日期:2017-12-04 00:00:00
abstract:BACKGROUND:The known risk factors for coronary heart disease among people prior suffering an out-of-hospital cardiac arrest with validated myocardial infarction aetiology and their thoughts about what lifestyle means to them after surviving have rarely been described. Therefore the aim of the study was to describe risk...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-13-62
更新日期:2013-08-27 00:00:00
abstract:BACKGROUND:To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01491-4
更新日期:2020-05-18 00:00:00
abstract:BACKGROUND:The arterial wall possesses several functional and structural properties that define arterial health. Once they become impaired, cardiovascular risk increases. We aimed to ascertain the pattern of correlations among different arterial wall properties and to explore their relations to traditional risk factors...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-12-29
更新日期:2012-04-25 00:00:00
abstract:BACKGROUND:In Denmark and other countries, there has been a shift in the management of patients with an implantable cardioverter defibrillator (ICD) with remote device monitoring largely replacing in-hospital visits. Less patient-nurse and patient-physician interaction may lead to gaps in patients' quality of care and ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0872-7
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk individuals. The aim of this meta-analysis was to assess the efficacy of allopurinol treatment in red...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析
doi:10.1186/s12872-018-0881-6
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based intervention, for men and women aged between 45 and 64 years without pre-existing coronary heart disease, ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-8-18
更新日期:2008-07-26 00:00:00
abstract:BACKGROUND:Heart failure is a major and growing medical and economic problem worldwide as 1-2% of the healthcare budget are spent for heart failure. The prevalence of heart failure has increased over the past decades and it is expected that there will be further raise due to the higher proportion of elderly in the west...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0815-3
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is increasingly used to assess myocardial involvement in patients with Fabry disease, an X linked lipid storage disorder. However, it is often proposed as an optional tool. A different cardiomyopathic disease progression b...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-86
更新日期:2014-07-16 00:00:00
abstract:BACKGROUND:Patients with systemic lupus erythematosus (SLE) have increased cardiovascular morbidity and mortality. Although autopsy studies have documented that the heart is affected in most SLE patients, clinical manifestations occur in less than 10%. QT dispersion is a new parameter that can be used to assess homogen...
journal_title:BMC cardiovascular disorders
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2261-12-11
更新日期:2012-02-27 00:00:00
abstract:BACKGROUND:Sudden cardiac death (SCD) among the young is a rare and devastating event, but its exact incidence in many countries remains unknown. An autopsy is recommended in every case because some of the cardiac pathologies may have a genetic origin, which can have an impact on the living family members. The aims of ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-140
更新日期:2014-10-07 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that ABPM more closely predicts target organ damage than does clinic measurement. Future guidelines may suggest ABPM as routine in the diagnosis and monitoring of hypertension. This would create difficulties as this test is expensive and often difficult to obtain. The purpose of ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-5-18
更新日期:2005-06-28 00:00:00
abstract:BACKGROUND:Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron load on proteolysis ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/1471-2261-14-49
更新日期:2014-04-12 00:00:00
abstract:BACKGROUND:Adverse effects, treatment resistance and high costs associated with pharmacological treatment of hypertension have led to growing interest in non-pharmacological complementary therapies such as music interventions. This meta-analysis aims to provide an overview of reported evidence on the efficacy of music ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12872-016-0244-0
更新日期:2016-04-19 00:00:00
abstract:BACKGROUND:The aim of the study was to investigate the relationship between the ejection fraction (EF) and the mitral annular systolic velocity (Sm) in patients with preserved left ventricular systolic function (EF>55%). The study task was to evaluate whether the assessment of Sm(avg) can be used as an alternative to t...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2261-13-92
更新日期:2013-10-26 00:00:00
abstract:BACKGROUND:Transradial access (TRA) has been considered as the default choice in cardiac catheterization. Although infrequent, vascular complications of this approach remain. Recently, the distal transradial approach (dTRA) in cardiac catheterization was reported by interventionalists. METHODS:We retrieved the relevan...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章,评审
doi:10.1186/s12872-020-01625-8
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:The incidence and mortality of cardiovascular diseases (CVDs) in low and middle income countries (LMICs) have been increasing, while access to CVDs medicines is suboptimal. We assessed selection of essential medicines for the prevention and treatment of CVDs on national essential medicines lists (NEMLs) of L...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-018-0858-5
更新日期:2018-06-25 00:00:00
abstract:BACKGROUND:Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. METHODS:Pulse...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-020-01376-6
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Although various iatrogenic complications could be observed in the process of permanent pacemaker implantation, pacemaker electrode mistakenly implanted into left ventricle via subclavian artery and aortic valve has not been reported. CASE PRESENTATION:Herein, we reported a 71-year-old woman with permanent ...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-015-0032-2
更新日期:2015-05-12 00:00:00