Abstract：
BACKGROUND:The aim of this study was to assess significance of serum neutrophil gelatinase-associated lipocalin (sNGAL) and cystatin C (sCC) in prediction of adverse cardiovascular outcome after ST-segment elevation myocardial infarction (STEMI). METHODS:We recruited 357 consecutive patients who were admitted to the hospital within 24 h after onset of STEMI. On the 1st and 12th-14th day after hospital admission, we measured levels of sNGAL and sCC. We also determined presence of renal dysfunction (RD), defined as glomerular filtration rate < 60 mL/min/1.73 m2. After 3 years of follow-up, we performed a logistic regression and assessed the value of RD, sNGAL, and sCC in prediction of combined endpoint, defined as cardiovascular death or any cardiovascular complication. RESULTS:RD, sCC level ≥ 1.9 mg/L, and sNGAL level ≥ 1.25 ng/mL on the 12th-14th day of hospitalization were associated with a 1.6-fold, 1.9-fold, and 2.9-fold higher risk of adverse cardiovascular outcome, respectively. Area under the ROC curve was the highest for the model based on sNGAL level compared to the models based on sCC level or RD presence. CONCLUSIONS:Measurement of sNGAL level in patients with STEMI on the 12th-14th day after hospital admission may improve prediction of adverse cardiovascular outcome.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Barbarash OL,Bykova IS,Kashtalap VV,Zykov MV,Hryachkova ON,Kalaeva VV,Shafranskaya KS,Karetnikova VN,Kutikhin AGdoi
10.1186/s12872-017-0514-5subject
Has Abstractpub_date
2017-03-15 00:00:00pages
81issue
1issn
1471-2261pii
10.1186/s12872-017-0514-5journal_volume
17pub_type
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