Abstract:
BACKGROUND:Low molecular weight heparins hold several advantages over unfractionated heparin including convenience of administration. Enoxaparin is one such heparin licensed in the UK for use in unstable coronary artery disease (unstable stable angina and non-Q wave myocardial infarction). In these patients, two large randomised controlled trials and their meta-analysis showed small benefits for enoxaparin over unfractionated heparin at 30-43 days and potentially at one year. We found no relevant published full economic evaluations, only cost studies, one of which was conducted in the UK. The other studies, from the US, Canada and France, are difficult to interpret since their resource use and costs may not reflect UK practice. METHODS:We aimed to compare the benefits and costs of short-term treatment (two to eight days) with enoxaparin and unfractionated heparin in unstable coronary artery disease. We used published data sources to estimate the incremental cost per quality adjusted life year (QALY), adopting a NHS perspective and using 1998 prices. RESULTS:The base case was a 0.013 QALY gain and net cost saving of 317 pounds sterling per person treated with enoxaparin instead of unfractionated heparin. All but one sensitivity analysis showed net savings and QALY gains, the exception (the worst case) being a cost per QALY of 3,305 pounds sterling. Best cases were a 495 pounds sterling saving and 0.013 QALY gain, or a 317 pounds sterling saving and 0.014 QALY gain per person. CONCLUSIONS:Enoxaparin appears cost saving compared with unfractionated heparin in patients with unstable coronary artery disease. However, cost implications depend on local revascularisation practice.
journal_name
BMC Cardiovasc Disordjournal_title
BMC cardiovascular disordersauthors
Nicholson T,McGuire A,Milne Rdoi
10.1186/1471-2261-1-2keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
2issn
1471-2261journal_volume
1pub_type
杂志文章,评审abstract:BACKGROUND:Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population. METHODS:In our case-control study, we recruited 755 unrelated partici...
journal_title:BMC cardiovascular disorders
pub_type: 杂志文章
doi:10.1186/s12872-016-0188-4
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abstract:BACKGROUND:Renal denervation (RDN) targeting the sympathetic nerves in the renal arterial adventitia as a treatment of resistant hypertension can cause endothelial injury and vascular wall injury. This study aims to evaluate the risk of atherosclerosis induced by RDN in renal arteries. METHODS:A total of 15 minipigs w...
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更新日期:2017-04-04 00:00:00
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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更新日期:2012-04-25 00:00:00
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更新日期:2020-06-05 00:00:00
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更新日期:2017-07-03 00:00:00
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更新日期:2020-02-11 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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