Abstract:
BACKGROUND:Monocytes are the predominant innate immune cells at the early stage of Mycobacterium tuberculosis (M. tb) infection as the host defense against intracellular pathogens. Understanding the profile of different monocyte subpopulations and the dynamics of monocyte-related biomarkers may be useful for the diagnosis and prognosis of tuberculosis. METHODS:We enrolled 129 individuals comprising patients with pulmonary tuberculosis (PTB) (n = 39), tuberculous pleurisy (TBP) (n = 28), malignant pleural effusion (MPE) (n = 21), latent tuberculosis infection (LTBI) (n = 20), and healthy controls (HC) (n = 21). Surface expression of CD14, CD16, and CD163 on monocytes was detected using flow cytometry. In addition, soluble CD163 (sCD163) was determined by enzyme linked immunosorbent assay. RESULTS:Higher frequency of CD14+CD16+ (15.7% vs 7.8%, P < 0.0001) and CD14-CD16+ (5.3% vs 2.5%, P = 0.0011) monocytes and a decreased percentage of CD14+CD16- (51.0% vs 70.4%, P = 0.0110) cells was observed in PTB patients than in HCs. Moreover, PTB patients displayed a higher frequency of CD163+ cells in CD16+ monocytes than those in the HC group (40.4% vs 11.3%, P < 0.0001). The level of sCD163 was elevated in TBP patients and was higher in pleural effusion than in plasma (2116.0 ng/ml vs 1236.0 ng/ml, P < 0.0001). sCD163 levels in pleural effusion and plasma could be used to distinguish TBP from MPE patients (cut-off values: 1950.0 and 934.7 ng/ml, respectively; AUCs: 0.8418 and 0.8136, respectively). Importantly, plasma sCD163 levels in TBP patients decreased significantly after anti-TB treatment. CONCLUSIONS:Higher expression of membrane and soluble CD163 in active tuberculosis patients might provide insights regarding the pathogenesis of tuberculosis, and sCD163 may be a novel biomarker to distinguish TBP from MPE and to predict disease severity.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Liu Q,Ou Q,Chen H,Gao Y,Liu Y,Xu Y,Ruan Q,Zhang W,Shao Ldoi
10.1186/s12879-019-4525-ysubject
Has Abstractpub_date
2019-11-28 00:00:00pages
1006issue
1issn
1471-2334pii
10.1186/s12879-019-4525-yjournal_volume
19pub_type
杂志文章abstract:BACKGROUND:Fungal infections are diagnosed increasingly often in patients affected by hematological diseases and their mortality has remained high. The recent development of new antifungal drugs gives the clinician the possibility to assess the combination of antifungal drugs with in-vitro or in animal-model synergisti...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-28
更新日期:2007-04-18 00:00:00
abstract:BACKGROUND:In comparison to restriction fragment length polymorphism (RFLP) typing, variable number of tandem repeat (VNTR) typing is easier to perform, faster and yields results in a simple, numerical format. Therefore, this technique has gained recognition as the new international gold standard in typing of Mycobacte...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-63
更新日期:2013-02-02 00:00:00
abstract:BACKGROUND:Studies report serious adherence problems among youth (individuals age 15-24 years of age) in Uganda. Recent growth in mobile phone ownership has highlighted the potential of using text-based interventions to improve antiretroviral treatment (ART) adherence among Ugandan youth. We piloted a randomized contro...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12879-020-4896-0
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:There is an established correlation between maternal education and reduction in childhood mortality. One proposed link is that an increase in maternal education will lead to an increase in health care access and vaccine uptake. Vaccinations are a central preventative child health tool, therefore demonstratin...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12879-017-2890-y
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:COVID-19 is an emerging respiratory disease caused by a novel coronavirus. There is not much evidence assessing the knowledge of dental surgeons regarding COVID-19. This study was conducted to assess the knowledge of COVID-19 among dental surgeons of Nepal. METHODS:A web-based cross-sectional study was cond...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05620-4
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Cutaneous leishmaniasis (CL) is an important public health problem in Brazil and in several tropical regions of the world. In the Americas, Brazil is the country with the highest number of registered cases. In Brazil, the state of Minas Gerais has the highest number of cases in the southeastern region. In th...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3940-4
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two consecutive VL ≥1000 copies/mL (at...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-018-2979-y
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3072-2
更新日期:2018-04-04 00:00:00
abstract:BACKGROUND:The purpose of this study was to further characterize the immune response to Mycobacterium tuberculosis (Mtb) antigens, in order to provide new insight into host-pathogen interactions in tuberculosis (TB), and to offer tools for a more accurate diagnosis of the different stages of TB. METHODS:T-cell respons...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-9-99
更新日期:2009-06-23 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is an important pathogen that can cause severe illness in infants and young children. In this study, we assessed whether data on RSV collected by the European Influenza Surveillance Scheme (EISS) could be used to build an RSV surveillance system in Europe. METHODS:Influenza...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-128
更新日期:2006-08-09 00:00:00
abstract:BACKGROUND:Long-term outcome of DAAs therapy in kidney transplant recipients was unknown. Thus, we aimed to evaluate it in a Chinese cohort of HCV-infected kidney transplant recipients. METHODS:Single-center and retrospective study of HCV-infected kidney transplant recipients initiating an DAAs regimen between January...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/s12879-019-4217-7
更新日期:2019-07-19 00:00:00
abstract:BACKGROUND:Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). METHODS:The study includes 213 ICU patients with clinical criteria of sepsi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2606-3
更新日期:2017-08-09 00:00:00
abstract:BACKGROUND:The burden of mother-to-child transmission rate of HIV is high and risk factors are common in Ethiopia. This systematic review and meta-analysis intended to provide the pooled estimation of mother-to-child transmission rate and its risk factors in Ethiopia. METHODS:We searched PubMed, Google Scholar, EMBASE...
journal_title:BMC infectious diseases
pub_type: 杂志文章,meta分析
doi:10.1186/s12879-018-3189-3
更新日期:2018-06-22 00:00:00
abstract:BACKGROUND:The preferred regimen for HIV post-exposure prophylaxis (PEP) is based mainly on safety and tolerability because it is given to immunocompetent people without HIV infection for a limited time (28 days). The frequency of adverse events (AEs) may be > 60%. Although AEs are generally not severe, they can lead t...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2056-3
更新日期:2016-11-29 00:00:00
abstract:BACKGROUND:It is believed that the current prevalence of malaria in endemic areas reflects selection for the carrier form of sickle cell trait through a survival advantage. Malaria has been incriminated as a great cause of mortality in people with sickle cell disease (SCD). However, people with SCD, a high-risk group, ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4757-x
更新日期:2020-01-14 00:00:00
abstract:BACKGROUND:Brucellosis is a zoonotic disease caused by brucella. It has been an increasing trend in recent years (Wang H, Xu WM, Zhu KJ, Zhu SJ, Zhang HF, Wang J, Yang Y, Shao FY, Jiang NM, Tao ZY, Jin HY, Tang Y, Huo LL, Dong F, Li ZJ, Ding H, Liu ZG, Emerg Microbes Infect 9:889-99, 2020). Brucellosis is capable to in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05358-z
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:The risk of life-threatening complications, such as visceral disseminated varicella zoster virus (VZV) infection, is greater in immunosuppressed individuals, such as systemic lupus erythematosus (SLE) patients. CASE PRESENTATION:Here, a case is reported of a Caucasian woman diagnosed with lupus nephritis an...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05254-6
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND:Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-1475-5
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:Early infant diagnosis of HIV infection is challenging in sub-Saharan Africa, particularly in rural areas, leading to delays in diagnosis and treatment. Use of a point-of-care test would overcome many challenges. This study evaluated the validity of a novel point-of-care p24 antigen detection test (LYNX) in ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-021-05808-2
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:To assess the economic aspects of HBV (hepatitis B virus) transmission prevention for premarriage individuals in a country with cultural backgrounds like Iran and intermediate endemicity of HBV infection. METHODS:A cost-effectiveness analysis model was used from the health care system and society perspectiv...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-4-31
更新日期:2004-09-04 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) associated malignancies are the leading cause of cancer death in Botswana. We sought to determine causative HPV types in patients with anogenital malignancies in Botswana to inform vaccine strategy. METHODS:We used formalin-fixed and paraffin-embedded (FFPE) tissue blocks from pat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2832-8
更新日期:2017-11-25 00:00:00
abstract:BACKGROUND:Oxidative stress plays a vital role in the pathogenesis of both Sickle Cell Disease (SCD) and Plasmodium falciparum malaria. However, there are limited studies on the effect of P. falciparum malaria infection on oxidative stress in SCD patients. METHODS:A cross-sectional study was undertaken to compare leve...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4221-y
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk, the relationship between tuberculosis as a causative factor for IR remains unclear. The study aime...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2657-5
更新日期:2017-08-15 00:00:00
abstract:BACKGROUND:The Australian state of Victoria, with 5.2 million residents, enforced home quarantine during a H1N1 pandemic in 2009. The strategy was targeted at school children. The objective of this study was to investigate the extent to which parents' access to paid sick leave or paid carer's leave was associated with ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-12-311
更新日期:2012-11-20 00:00:00
abstract:BACKGROUND:HIV-infected patients starting antiretroviral treatment (ART) experience deep and early disorders in fat and bone metabolism, leading to concomitant changes in fat mass and bone mineral density. METHODS:We conducted a prospective study in treatment-naive HIV-infected patients randomized to receive two nucle...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-13-293
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile. METHODS:52 adult patients were enrolled in the study. B...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-7-137
更新日期:2007-11-22 00:00:00
abstract:BACKGROUND:To ensure sustainable routine surveillance of mosquito vectors, simple, effective and ethically acceptable tools are required. As a part of that, we evaluated the efficiency of resting boxes baited with fresh and aging cattle urine for indoor and outdoor sampling of An. arabiensis in the lower Moshi rice irr...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-172
更新日期:2010-06-15 00:00:00
abstract:BACKGROUND:The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda. METHODS:HIV-negative, high-risk women were seen q...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-11-333
更新日期:2011-12-02 00:00:00
abstract:BACKGROUND:Models of infectious disease are increasingly utilising empirical contact data to quantify the number of potentially infectious contacts between age groups. While a growing body of data is being collected on contact patterns across many populations, less attention has been paid to the social contacts of youn...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2735-8
更新日期:2017-09-20 00:00:00
abstract:BACKGROUND:The importance of multidrug-resistant organisms (MDRO) in Chinese hospitals is not clearly delineated. Thus we sought to assess the prevalence of MDRO in Chinese intensive care units (ICUs). METHODS:Prospective study of inpatients admitted consecutively to eight ICUs in four Chinese cities in 2009-10. Admis...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-015-1105-7
更新日期:2015-08-21 00:00:00