Abstract：
BACKGROUND:Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). METHODS:The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. RESULTS:PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73-0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). CONCLUSION:PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. TRIAL REGISTRATION:NCT01535534 . Registered 14.02.2012.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Hamed S,Behnes M,Pauly D,Lepiorz D,Barre M,Becher T,Lang S,Akin I,Borggrefe M,Bertsch T,Hoffmann Udoi
10.1186/s12879-017-2606-3subject
Has Abstractpub_date
2017-08-09 00:00:00pages
554issue
1issn
1471-2334pii
10.1186/s12879-017-2606-3journal_volume
17pub_type
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