Abstract:
BACKGROUND:Non-organ-specific autoantibodies are found in a considerable number of anti-HCV positive patients. Previous studies investigated the clinical relevance of these antibodies in patients treated with interferon monotherapy, but not combination therapies. METHODS:Anti-nuclear, anti-smooth muscle, anti-mitochondrial, anti-neutrophil-cytoplasmatic and anti-liver/kidney microsomal antibodies were determined in 78 consecutive anti-HCV positive patients by indirect immunofluorescence. The presence of these antibodies was related to demographic variables and to the outcome of antiviral combination therapy with interferon-alpha and ribavirin in 65 patients. RESULTS:In our study, positivity for autoantibodies was associated with higher alanine aminotransferase levels and higher mean values for HCV-RNA (p < 0.01). Furthermore, negativity for non-organ-specific autoantibodies was associated with a favourable treatment outcome of combination therapy with at least one negative RT-PCR for HCV-RNA during treatment (OR 4.65, 95% CI 1.31 to 16.48, p = 0.02). ANA and SMA staining patterns and titers were not correlated to treatment response. With multiple logistic regression analysis, positivity for autoantibodies and HCV genotype were independently associated with outcome of antiviral combination therapy (p = 0.02). CONCLUSIONS:The absence of non-organ-specific autoantibodies might indicate a significantly higher chance for viral clearance in response to combination therapy for chronic hepatitis C infection. Therefore, despite of an overall higher treatment response, the addition of the immunomodulatory drug ribavirin could accentuate immunological differences that affect treatment outcome and might have been less obvious in earlier studies analysing interferon monotherapy.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Wasmuth HE,Stolte C,Geier A,Dietrich CG,Gartung C,Lorenzen J,Matern S,Lammert Fdoi
10.1186/1471-2334-4-4keywords:
subject
Has Abstractpub_date
2004-02-13 00:00:00pages
4issn
1471-2334pii
1471-2334-4-4journal_volume
4pub_type
杂志文章abstract:BACKGROUND:Hand, foot and mouth disease (HFMD) is a major communicable disease in children ≤6 years old, particularly in several countries in the Asia-Pacific Region, including Thailand. HFMD impacts public health and the economy, especially in northern Thailand. METHODS:A prospective cohort study was conducted to est...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3560-4
更新日期:2018-12-06 00:00:00
abstract:BACKGROUND:The risk factors, microbial etiology, differentiation, and clinical features of purulent and non-purulent cellulitis are not well defined in Taiwan. METHODS:We conducted a retrospective cohort study of hospitalized adults with cellulitis in Taiwan in 2013. The demographic characteristics, underlying disease...
journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3050-8
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Antimicrobial resistance in Mycoplasma genitalium is rising globally with resultant clinical treatment failure. We investigated the prevalence of mutations in the macrolide and fluoroquinolone resistance-determining regions of M. genitalium in Johannesburg, South Africa, and ascertained their association wit...
journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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journal_title:BMC infectious diseases
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更新日期:2018-05-22 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2012-11-09 00:00:00
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journal_title:BMC infectious diseases
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更新日期:2015-07-08 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2014-04-11 00:00:00
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更新日期:2020-10-16 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-18
更新日期:2013-01-17 00:00:00
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abstract:BACKGROUND:Pregnant women in malaria endemic areas are at high risk of P. falciparum infection and its complications. This study investigated the prevalence and risk factors for P. falciparum infection and malaria among pregnant women reporting for first antenatal care (ANC) clinic visit in the mount Cameroon area. ME...
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journal_title:BMC infectious diseases
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更新日期:2009-02-09 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2018-11-14 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-12 00:00:00
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journal_title:BMC infectious diseases
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更新日期:2018-11-06 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2015-08-18 00:00:00
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更新日期:2015-07-29 00:00:00
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journal_title:BMC infectious diseases
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更新日期:2017-01-19 00:00:00
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journal_title:BMC infectious diseases
pub_type: 杂志文章
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更新日期:2020-01-06 00:00:00