Abstract:
BACKGROUND:Implant-related infections, including those of peri-prosthetic joint (PJIs), osteosynthesis and other biomaterials, are biofilm-related. Pathogen identification is considered the diagnostic benchmark; however, the presence of bacterial biofilms makes pathogen detection with traditional microbiological techniques only partially effective. To improve microbiological diagnostic accuracy, some biofilm debonding techniques have been recently proposed. Aim of this health economics assessment study was to evaluate their economic impact on hospital costs. METHODS:Direct and indirect hospital costs connected with the routine introduction of sonication and dithiothreitol treatment applied to hip and knee PJIs and of tissue cultures were examined. In particular the consequences of diagnostic inaccuracy, the opportunities, costs, and risks of each technique were calculated. RESULTS:Considering an average of five samples per patient, processed separately with traditional tissue culture with or without sonication of prosthetic components, or pooled together using the MicroDTTect device (a close system for sample collection, transport and treatment with Dithiothreitol for microbial release from biofilm), the overall mean direct cost per patient was € 397 and € 393 for sonication or MicroDTTect, respectively, compared to € 308 for traditional tissue cultures. In terms of opportunity costs, MicroDTTect was the most effective technique, allowing for a 35% or 55% reduction in time required for sample treatment, compared to tissue cultures combined or not with sonication, respectively. Pooling together direct and indirect costs associated with false positive and negative results of the different diagnostic techniques, unnecessary medical treatments and possible medical claims, MicroDTTect or sonication become increasingly cost-effective when the extra-costs, generated by diagnostic inaccuracy of traditional tissue culture, took place, respectively, in 2% or 20% or more of the patients. CONCLUSIONS:This is the first study specifically focused on the economic impact of the routine clinical use of microbiological antibiofilm sampling and processing techniques in orthopaedics. Although our results may suffer from a potential country and hospital bias, as the data collection process for direct and indirect costs is specific to each institution and country, this analysis highlights the potential economic advantage to hospitals associated with the routine introduction of antibiofilm techniques for microbiological diagnosis of PJI.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Romanò CL,Trentinaglia MT,De Vecchi E,Logoluso N,George DA,Morelli I,Drago Ldoi
10.1186/s12879-018-3050-8subject
Has Abstractpub_date
2018-04-02 00:00:00pages
154issue
1issn
1471-2334pii
10.1186/s12879-018-3050-8journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Over the past several years, new diagnostic techniques have been developed to allow for the rapid detection of multidrug resistant tuberculosis. The GenoType MTBDRplus test is a deoxyribonucleic acid (DNA) strip assay which uses polymerase chain reaction (PCR) and hybridization to detect genetic mutations in...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-123
更新日期:2010-05-20 00:00:00
abstract:BACKGROUND:Cytopenias are the most common HIV-associated hematological abnormality. Cytopenias have been associated with several factors including sex, race/ethnicity, geographical location and comorbidities such as tuberculosis, hepatitis B infection, fever and oral candidiasis. Cytopenias become more prevalent as HIV...
journal_title:BMC infectious diseases
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2334-14-496
更新日期:2014-09-10 00:00:00
abstract:BACKGROUND:War-wounded civilians in Middle East countries are at risk of post-traumatic osteomyelitis (PTO). We aimed to describe and compare the bacterial etiology and proportion of first-line antibiotics resistant bacteria (FLAR) among PTO cases in civilians from Syria, Iraq and Yemen admitted to the reconstructive s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-3741-9
更新日期:2019-01-31 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is a major public health problem in developing countries like Bangladesh. Female sex workers (FSWs) and their clients are active sources for spreading TB. The purpose of this study was to assess the knowledge of TB among FSWs in Rajshahi city, Bangladesh. METHODS:It was a cross-sectional s...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4531-0
更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterial pathogen which can invade different mammalian cells and reach to the central nervous system (CNS), leading to meningoencephalitis and brain abscesses. In the diagnosis of L. monocytogenes meningoencephalitis (LMM), the traditi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05447-z
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The presence of diabetes mellitus increases the risk of several severe infections, but data on its effect on treatment outcomes in patients with nosocomial pneumonia (NP) caused by methicillin-resistant Staphylococcus aureus (MRSA) are limited. METHODS:We retrospectively analyzed data from a double-blind, r...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12879-016-1779-5
更新日期:2016-09-06 00:00:00
abstract:BACKGROUND:The present study was performed to assess the prognosis of patients admitted to the intensive care unit (ICU) for community acquired pneumonia (CAP) after implementation of new processes of care. METHODS:Two groups of patients with CAP were admitted to a 16-bed multidisciplinary ICU in an urban teaching hos...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-13-196
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:In order to investigate the epidemiology, molecular characteristics, and distribution of extended-spectrum β-lactamase (ESBL)- and AmpC-producing Escherichia coli from community-onset infections in Chinese county hospitals. METHODS:E. coli isolates were collected from patients with community-onset infection...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0659-0
更新日期:2014-12-03 00:00:00
abstract:BACKGROUND:This study aimed to identify ten different 16S rRNA methyltransferase genes (rmtA, rmtB, rmtC, rmtD, armA, rmtF, npmA, rmtH, rmtE and rmtG) and their coexisting ESBL and carbapenemase with the emergence of three E.coli clones within a single study centre. METHODS:A total of 329 non-duplicate E.coli isolates...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-020-05264-4
更新日期:2020-07-25 00:00:00
abstract:BACKGROUND:Viral central nervous system (CNS) infections are common in countries where malaria is endemic but, due to limited laboratory facilities, few studies have systematically examined the prevalence and clinical consequences of the presence of viruses in cerebrospinal fluid (CSF) from children with suspected CNS ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0630-0
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:In 2007, Park et al. identified a novel serotype among Streptococcus pneumoniae serogroup 6 which they named serotype 6C. The aim of this study was to evaluate with the Neufeld test a novel S. pneumoniae serotype 6C type specific polyclonal antiserum. In addition, serotype 6C isolates found in Denmark in 200...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-10-282
更新日期:2010-09-24 00:00:00
abstract:BACKGROUND:Active tuberculosis (TB) is common among HIV-infected persons living in tuberculosis endemic countries, and screening for tuberculosis (TB) is recommended routinely. We sought to determine the role of chest x-ray and sputum culture in the decision to treat for presumptive TB using active case finding in a la...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-8-32
更新日期:2008-03-06 00:00:00
abstract:BACKGROUND:The objective of this study was to establish 1) the performance of chest X-ray (CXR) in all suspects of tuberculosis (TB), as well as smear-negative TB suspects and 2) to compare the cost-effectiveness of the routine diagnostic pathway using Ziehl-Neelsen (ZN) sputum microscopy followed by CXR if case of neg...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-5-111
更新日期:2005-12-12 00:00:00
abstract:BACKGROUND:Demographic characteristic surveillance of transfusion-transmitted infections (TTIs) among blood donors is crucial to formulating control strategies and preventing TTIs. This study aimed to investigate the demographic characteristics and social factors associated with TTIs among blood donors from 14 differen...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4044-x
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Collecting adequate information on key epidemiological indicators is a prerequisite to informing a public health response to reduce the impact of hepatitis C virus (HCV) infection in Malaysia. Our goal was to overcome the acute data shortage typical of low/middle income countries using statistical modelling ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0564-6
更新日期:2014-11-07 00:00:00
abstract:BACKGROUND:Syndromic management of STIs has been advocated as simplified and cheap approach. Youth have been reported to be at increased risk of acquiring STIs which can facilitate HIV transmission. We have investigated the relationship between the syndromic management and specific aetiology diagnosis and its relations...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-22
更新日期:2006-02-10 00:00:00
abstract:BACKGROUND:Despite the adoption of the provider-initiated HIV testing strategy, the rate of HIV testing is still very low in sub-Saharan Africa. The aim of this study was to assess the factors associated with HIV testing among sexually active women and men in Senegal. Knowledge of HIV status is the gateway to antiretro...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4717-5
更新日期:2019-12-31 00:00:00
abstract:BACKGROUND:HIV controllers (HICs) are a rare group of HIV-1-infected individuals able to naturally control viral replication. Several studies have identified the occurrence of HIV dual infections in seropositive individuals leading to disease progression. In HICs, however, dual infections with divergent outcomes in pat...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-019-4229-3
更新日期:2019-07-05 00:00:00
abstract:BACKGROUND:Kynurenine/Tryptophan ratio (KTR) is increased in HIV infection, and linked to immune activation. We hypothesized that early cART initiation results in lower KTR compared to late initiation. Furthermore, we hypothesized that KTR prior to cART is a predictor of the magnitude of subsequent reduction in immune ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2456-z
更新日期:2017-05-16 00:00:00
abstract:BACKGROUND:Giardia duodenalis is a flagellate parasite which has been considered the most common protozoa infecting human worldwide. Molecular characterization of G. duodenalis isolates have revealed the existence of eight groups (Assemblage A to H) which differ in their host distribution. Assemblages A and B are found...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-14-78
更新日期:2014-02-12 00:00:00
abstract:BACKGROUND:The real burden of smear-positive (PTB+) and bacteriologically confirmed tuberculosis (BCTB) in Ethiopia is not known. Thus, the aim of this community-based study was to measure the prevalence and incidence of tuberculosis in the Hetosa District of Oromia Region, Ethiopia. METHODS:First, a population-based ...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-017-2321-0
更新日期:2017-03-16 00:00:00
abstract:BACKGROUND:The 2009 revised World Health Organization (WHO) guidelines for dengue describe fever as the core symptom. Accordingly, the diagnosis of non-febrile patients is complicated. The aim of this study was to evaluate the importance of fever in patients with dengue according to the 2009 revised WHO classification....
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-016-2128-4
更新日期:2017-01-04 00:00:00
abstract:BACKGROUND:Respiratory syncytial virus (RSV) is an important pathogen that can cause severe illness in infants and young children. In this study, we assessed whether data on RSV collected by the European Influenza Surveillance Scheme (EISS) could be used to build an RSV surveillance system in Europe. METHODS:Influenza...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-6-128
更新日期:2006-08-09 00:00:00
abstract:BACKGROUND:Plasmodium falciparum malaria, is a major health problem in forested tribal belt of central India. Rapid and accurate methods are needed for the diagnosis of P. falciparum. We performed a blinded evaluation of the recently introduced Determine trade mark malaria pf test (Abbott, Laboratories, Japan) compared...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-1-10
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Human adenovirus type 3 (HAdV-3) and 7 (HAdV-7) cause significant morbidity and develop severe complications and long-term pulmonary sequelae in children. However, epidemiologic reports have suggested that nearly all highly severe or fatal adenoviral diseases in children are associated with HAdV-7 rather tha...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-018-3651-2
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause of nosocomial infection, in South Korea. METHODS:To evaluate the nationwide incidence of nosocomial SA-BSI, cases of SA-BSI were prospectively collected from 22 hospitals with over 500 beds over 4?months...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-014-0590-4
更新日期:2014-11-14 00:00:00
abstract:BACKGROUND:In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which the infectious agent spreads to different organs. METHODS:We injected a CJD agent into mice, either intracerebrally (ic) or intraperitoneally (ip) and mon...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/1471-2334-1-20
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predi...
journal_title:BMC infectious diseases
pub_type: 杂志文章
doi:10.1186/s12879-015-0888-x
更新日期:2015-03-26 00:00:00
abstract:BACKGROUND:A previous study explored factors discriminating colonization and true infection among non-transplant, non-neutropenic patients with repeated Aspergillus spp. isolation from lower respiratory samples. The present study explored the evolution of patients with Aspergillus colonization in that study to determin...
journal_title:BMC infectious diseases
pub_type: 杂志文章,多中心研究
doi:10.1186/s12879-016-2143-5
更新日期:2017-01-06 00:00:00
abstract:BACKGROUND:Growing evidence suggests respiratory syncytial virus (RSV) is an important cause of respiratory disease in adults. However, the adult burden remains largely uncharacterized as most RSV studies focus on children, and population-based studies with laboratory-confirmation of infection are difficult to implemen...
journal_title:BMC infectious diseases
pub_type: 临床试验,杂志文章
doi:10.1186/s12879-015-1218-z
更新日期:2015-10-23 00:00:00