Abstract:
BACKGROUND:Trichosporon mycotoxinivorans is a recently described yeast-like fungal organism and its association as a pathogen for patients with cystic fibrosis (CF) was reported previously. We show the clinical course of a CF patient over 9 years as well as the applications of modern molecular and proteomic identification techniques of this rare fungus. CASE PRESENTATION:We present the case of a 32-year-old male CF patient with sputum cultures continuously positive with the anamorphic yeast T. mycotoxinivorans during 9 years. Furthermore, susceptibility testing of T. mycotoxinivorans to different antifungals were performed. In addition, a rapid identification method of this novel fungal pathogen with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was applied using a simple extraction protocol. CONCLUSIONS:Our case presentation confirms T. mycotoxinivorans as a potential emerging pathogen in patients with CF. However, our CF patient showed mild symptoms over a very long time period of 9 years. A short MALDI-TOF MS procedure allows reliable and rapid identification of T. mycotoxinivorans and therefore should facilitate further study on the clinical relevance and epidemiology of this unusual fungal organism.
journal_name
BMC Infect Disjournal_title
BMC infectious diseasesauthors
Goldenberger D,Hinić V,Prince SS,Tamm M,Balestra AM,Hohler D,Frei Rdoi
10.1186/s12879-016-1910-7subject
Has Abstractpub_date
2016-10-25 00:00:00pages
601issue
1issn
1471-2334pii
10.1186/s12879-016-1910-7journal_volume
16pub_type
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