Evaluating clinical effectiveness of 13-valent pneumococcal conjugate vaccination against pneumonia among middle-aged and older adults in Catalonia: results from the EPIVAC cohort study.

Abstract:

BACKGROUND:Benefits using the 13-valent pneumococcal conjugate vaccine (PCV13) in adults are controversial. This study investigated clinical effectiveness of PCV13 vaccination in preventing hospitalisation from pneumonia among middle-aged and older adults. METHODS:Population-based cohort study involving 2,025,730 individuals ≥50 years in Catalonia, Spain, who were prospectively followed from 01/01/2015 to 31/12/2015. Primary outcomes were hospitalisation for pneumococcal or all-cause pneumonia and death from any cause. Cox regression models were used to evaluate the association between PCV13 vaccination and the risk of each outcome, adjusting for age, sex and major comorbidities/underlying risk conditions. RESULTS:Cohort members were observed for a total of 1,990,701 person-years, of which 6912 person-years were PCV13 vaccinated. Overall, crude incidence rates (per 100,000 person-years) were 82.8 (95% confidence interval [CI]: 77.7-88.1) for pneumococcal pneumonia, 637.9 (95% CI: 599.0-678.7) for all-cause pneumonia and 2367.2 (95% CI: 2222.8-2518.7) for all-cause death. After multivariable adjustments we found that the PCV13 vaccination did not alter significantly the risk of pneumococcal pneumonia (multivariable-adjusted hazard ratio [mHR]: 1.17; 95% CI: 0.75-1.83; p = 0.493) and all-cause death (mHR: 1.07; 95% CI: 0.97-1.18; p = 0.190), although it remained significantly associated with an increased risk of all-cause pneumonia (mHR: 1.69; 95% CI: 1.48-1.94; p < 0.001). In stratified analyses focused on middle-aged or elderly persons and immunocompromised or immunocompetent subjects, PCV13 vaccination did not appear effective either. CONCLUSION:Our data does not support clinical benefits of PCV13 vaccination against pneumonia among adults in Catalonia. It must be closely monitored in future studies involving more vaccinated person-time at-observation.

journal_name

BMC Infect Dis

journal_title

BMC infectious diseases

authors

Vila-Corcoles A,Ochoa-Gondar O,de Diego C,Satue E,Aragón M,Vila-Rovira A,Gomez-Bertomeu F,Magarolas R,Figuerola-Massana E,Raga X,Perez MO,Ballester F

doi

10.1186/s12879-018-3096-7

subject

Has Abstract

pub_date

2018-04-27 00:00:00

pages

196

issue

1

issn

1471-2334

pii

10.1186/s12879-018-3096-7

journal_volume

18

pub_type

杂志文章
  • Bacterial vaginosis, vaginal flora patterns and vaginal hygiene practices in patients presenting with vaginal discharge syndrome in The Gambia, West Africa.

    abstract:BACKGROUND:Bacterial vaginosis (BV) - a syndrome characterised by a shift in vaginal flora - appears to be particularly common in sub-Saharan Africa, but little is known of the pattern of vaginal flora associated with BV in Africa. We conducted a study aimed at determining the prevalence of BV and patterns of BV-associ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-5-12

    authors: Demba E,Morison L,van der Loeff MS,Awasana AA,Gooding E,Bailey R,Mayaud P,West B

    更新日期:2005-03-09 00:00:00

  • Sexually transmitted infections in Saudi Arabia.

    abstract:BACKGROUND:Data on sexually transmitted infections (STIs) in Saudi Arabia (SA) and other Islamic countries are limited. This study describes the results of a five-year surveillance for STIs in SA. METHODS:This is a case series descriptive study of all confirmed STIs diagnosed in SA from January, 1995 through December,...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-6-3

    authors: Madani TA

    更新日期:2006-01-10 00:00:00

  • Antimicrobial resistance of Neisseria gonorrhoeae in Germany: low levels of cephalosporin resistance, but high azithromycin resistance.

    abstract:BACKGROUND:The widespread antimicrobial resistance of Neisseria gonorrhoeae is a serious problem for the treatment and control of gonorrhoea. Many of the previously effective therapeutic agents are no longer viable. Because N. gonorrhoeae infections are not reportable in Germany, only limited data on disease epidemiolo...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-2944-9

    authors: Buder S,Dudareva S,Jansen K,Loenenbach A,Nikisins S,Sailer A,Guhl E,Kohl PK,Bremer V,GORENET study group.

    更新日期:2018-01-17 00:00:00

  • Comparison of two commercial broad-range PCR and sequencing assays for identification of bacteria in culture-negative clinical samples.

    abstract:BACKGROUND:Culturing has long been the gold standard for detecting aetiologic agents in bacterial infections. In some cases, however, culturing fails to detect the infection. To further investigate culture-negative samples, amplification and subsequent sequencing of the 16S rRNA gene is often applied. The aim of the pr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2333-9

    authors: Stavnsbjerg C,Frimodt-Møller N,Moser C,Bjarnsholt T

    更新日期:2017-03-27 00:00:00

  • Renal impairment in a rural African antiretroviral programme.

    abstract:BACKGROUND:There is little knowledge regarding the prevalence and nature of renal impairment in African populations initiating antiretroviral treatment, nor evidence to inform the most cost effective methods of screening for renal impairment. With the increasing availability of the potentially nephrotixic drug, tenofov...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-9-143

    authors: Franey C,Knott D,Barnighausen T,Dedicoat M,Adam A,Lessells RJ,Newell ML,Cooke GS

    更新日期:2009-08-28 00:00:00

  • Study and interest of cellular load in respiratory samples for the optimization of molecular virological diagnosis in clinical practice.

    abstract:BACKGROUND:Respiratory viral diagnosis of upper respiratory tract infections has largely developed through multiplex molecular techniques. Although the sensitivity of different types of upper respiratory tract samples seems to be correlated to the number of sampled cells, this link remains largely unexplored. METHODS:...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-016-1730-9

    authors: Bonnin P,Miszczak F,Kin N,Resa C,Dina J,Gouarin S,Viron F,Morello R,Vabret A

    更新日期:2016-08-09 00:00:00

  • AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies.

    abstract:BACKGROUND:In high-income settings, the spectrum of morbidity and mortality experienced by Human Immunodeficiency Virus (HIV)-infected individuals receiving combination antiretroviral therapy (cART) has switched from predominantly AIDS-related to non-AIDS-related conditions. In the context of universal access to care, ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-278

    authors: Luz PM,Bruyand M,Ribeiro S,Bonnet F,Moreira RI,Hessamfar M,Campos DP,Greib C,Cazanave C,Veloso VG,Dabis F,Grinsztejn B,Chêne G,IPEC\/FIOCRUZ Cohort and the Aquitaine ANRS C03 Study Group.

    更新日期:2014-05-21 00:00:00

  • Legionnaire's disease presenting as bilateral central scotomata: a case report.

    abstract:BACKGROUND:Legionnaire's disease is one of the major causes of community-acquired pneumonia and is occasionally complicated by neurological symptoms. However, reports of ocular lesions due to Legionnaire's disease are limited. CASE PRESENTATION:We report the case of a patient with Legionnaire's disease presenting as b...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-020-05715-y

    authors: Yamada S,Kitajima T,Marumo S,Fukui M

    更新日期:2021-01-07 00:00:00

  • Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.

    abstract:BACKGROUND:The steady rise in the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) requires rapid and reliable methods to identify resistant strains. The current molecular methods to detect MTB resistance to second-line drugs either do not cover an extended spectr...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-240

    authors: Zimenkov DV,Antonova OV,Kuz'min AV,Isaeva YD,Krylova LY,Popov SA,Zasedatelev AS,Mikhailovich VM,Gryadunov DA

    更新日期:2013-05-24 00:00:00

  • The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort.

    abstract:BACKGROUND:With ageing of the HIV-infected population, long-term exposure to treatment, varying adherence, emerging resistance and complications to therapies, effectiveness of Highly Active Antiretroviral Therapy (HAART) needs to be monitored continuously at the population level. The German HIV-1 Seroconverter Cohort i...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-12-94

    authors: Altmann M,An der Heiden M,Scheufele R,Hartmann K,Houareau C,Bartmeyer B,Hamouda O,German HIV-1 Seroconverter Cohort.

    更新日期:2012-04-19 00:00:00

  • The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis.

    abstract:BACKGROUND:NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal mechanisms. TNF-alpha synthesis is markedly reduced in MTB-antige...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-7-96

    authors: Lala S,Dheda K,Chang JS,Huggett JF,Kim LU,Johnson MA,Rook GA,Keshav S,Zumla A

    更新日期:2007-08-16 00:00:00

  • Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data.

    abstract:BACKGROUND:Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan. MET...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-262

    authors: Terlikbayeva A,Hermosilla S,Galea S,Schluger N,Yegeubayeva S,Abildayev T,Muminov T,Akiyanova F,Bartkowiak L,Zhumadilov Z,Sharman A,El-Bassel N

    更新日期:2012-10-18 00:00:00

  • ELISA is superior to bacterial culture and agglutination test in the diagnosis of brucellosis in an endemic area in China.

    abstract:BACKGROUND:Brucellosis is endemic in many areas in China. The current diagnosis of Brucellosis predominantly relies on the traditional bacterial culture and serum agglutination test. In this study, we aimed to explore the value of ELISA in the diagnosis of Brucellosis in Chinese population. METHODS:We recruited 235 pa...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4729-1

    authors: Xu N,Wang W,Chen F,Li W,Wang G

    更新日期:2020-01-06 00:00:00

  • Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.

    abstract:BACKGROUND:For a long time, the role of CD8(+) T cells in blood-stage malaria was not considered important because erythrocytes do not express major histocompatibility complex (MHC) class I proteins. While recent evidences suggest that CD8(+) T cells may play an important role during the erythrocytic phase of infection...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0762-x

    authors: Hojo-Souza NS,Pereira DB,Passos LS,Gazzinelli-Guimarães PH,Cardoso MS,Tada MS,Zanini GM,Bartholomeu DC,Fujiwara RT,Bueno LL

    更新日期:2015-01-31 00:00:00

  • An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP+.

    abstract::The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients, reduces their risk to develop leprosy by 60%. This...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3402-4

    authors: Mieras LF,Taal AT,van Brakel WH,Cambau E,Saunderson PR,Smith WCS,Prakoeswa CRS,Astari L,Scollard DM,do Nascimento DC,Grosset J,Kar HK,Izumi S,Gillini L,Virmond MCL,Sturkenboom MGG

    更新日期:2018-10-05 00:00:00

  • Discrepancy between effects of carbapenems and flomoxef in treating nosocomial hemodialysis access-related bacteremia secondary to extended spectrum beta-lactamase producing Klebsiella pneumoniae in patients on maintenance hemodialysis.

    abstract:BACKGROUND:Hemodialysis (HD) patients are susceptible to extended spectrum beta-lactamase (ESBL)-producing bacterial infections. Because the optimal treatment and clinical significance of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) HD access-related bacteremia remain unclear, we conducted this retrospective study to...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-206

    authors: Yang CC,Li SH,Chuang FR,Chen CH,Lee CH,Chen JB,Wu CH,Lee CT

    更新日期:2012-09-05 00:00:00

  • Comparison of virus isolation using the Vero E6 cell line with real-time RT-PCR assay for the detection of human metapneumovirus.

    abstract:BACKGROUND:The use of cell culture for the diagnosis of human metapneumovirus (hMPV) infection is uncommon at present and molecular method such as reverse-transcription PCR (RT-PCR) has been widely and most commonly used as the preferred test. We aimed to compare the results of virus isolation using Vero E6 cells with ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-10-170

    authors: Matsuzaki Y,Mizuta K,Takashita E,Okamoto M,Itagaki T,Katsushima F,Katsushima Y,Nagai Y,Nishimura H

    更新日期:2010-06-14 00:00:00

  • A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness.

    abstract:BACKGROUND:A vaccine matched to a newly emerged pandemic influenza virus would require a production time of at least 6 months with current proven techniques, and so could only be used reactively after the peak of the pandemic. A pre-pandemic vaccine, although probably having lower efficacy, could be produced and used p...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-14-266

    authors: Halder N,Kelso JK,Milne GJ

    更新日期:2014-05-16 00:00:00

  • Diagnostic value of symptoms and laboratory data for pertussis in adolescent and adult patients.

    abstract:BACKGROUND:Several symptoms are classically thought to be suggestive of pertussis in children, but the diagnostic value of these symptoms in adolescent and adult patients is unclear. We evaluated the accuracy of the clinical findings for the early presumptive diagnosis of pertussis in adolescent and adult patients. Fur...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-13-129

    authors: Miyashita N,Akaike H,Teranishi H,Kawai Y,Ouchi K,Kato T,Hayashi T,Okimoto N

    更新日期:2013-03-11 00:00:00

  • Using Baidu index to nowcast hand-foot-mouth disease in China: a meta learning approach.

    abstract:BACKGROUND:Hand, foot, and mouth disease (HFMD) has been recognized as one of the leading infectious diseases among children in China, which causes hundreds of annual deaths since 2008. In China, the reports of monthly HFMD cases usually have a delay of 1-2 months due to the time needed for collecting and processing cl...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3285-4

    authors: Zhao Y,Xu Q,Chen Y,Tsui KL

    更新日期:2018-08-13 00:00:00

  • Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom.

    abstract:BACKGROUND:Growing evidence suggests respiratory syncytial virus (RSV) is an important cause of respiratory disease in adults. However, the adult burden remains largely uncharacterized as most RSV studies focus on children, and population-based studies with laboratory-confirmation of infection are difficult to implemen...

    journal_title:BMC infectious diseases

    pub_type: 临床试验,杂志文章

    doi:10.1186/s12879-015-1218-z

    authors: Fleming DM,Taylor RJ,Lustig RL,Schuck-Paim C,Haguinet F,Webb DJ,Logie J,Matias G,Taylor S

    更新日期:2015-10-23 00:00:00

  • Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry.

    abstract:BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis is not well characterised. We have used baseline data of the Investigation o...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2334-6-2

    authors: Mayosi BM,Wiysonge CS,Ntsekhe M,Volmink JA,Gumedze F,Maartens G,Aje A,Thomas BM,Thomas KM,Awotedu AA,Thembela B,Mntla P,Maritz F,Blackett KN,Nkouonlack DC,Burch VC,Rebe K,Parish A,Sliwa K,Vezi BZ,Alam N,Brown BG

    更新日期:2006-01-06 00:00:00

  • Interleukin-28B gene non-TT allele strongly predicts treatment failure for genotype 1 infected chronic hepatitis C patients with advanced fibrosis: a case control study.

    abstract:BACKGROUND:The role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predi...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-0888-x

    authors: Hu CC,Lin CL,Chang LC,Chien CH,Chen LW,Liu CJ,Chien RN

    更新日期:2015-03-26 00:00:00

  • Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site.

    abstract:BACKGROUND:HIV-positive patients carry an increased risk of HPV infection and associated cancers. Therefore, prevalence and patterns of HPV infection at different anatomical sites, as well as theoretical protection of nonavalent vaccine should be investigated. Aim was to describe prevalence and predictors of oral HPV d...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2937-0

    authors: Vergori A,Garbuglia AR,Piselli P,Del Nonno F,Sias C,Lupi F,Lapa D,Baiocchini A,Cimaglia C,Gentile M,Antinori A,Capobianchi M,Ammassari A

    更新日期:2018-01-08 00:00:00

  • Prevalence of intestinal parasitic infections and associated risk factors among students at Dona Berber primary school, Bahir Dar, Ethiopia.

    abstract:BACKGROUND:Intestinal parasitic infections are still one of the major health concerns in developing countries. Monitoring of intestinal parasitic infection and associated risk factors are essential for intervention strategies. Therefore, the aim of this study was to assess the prevalence of intestinal parasitic infecti...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-017-2466-x

    authors: Hailegebriel T

    更新日期:2017-05-23 00:00:00

  • Multicenter case-control study protocol of pneumonia etiology in children: Global Approach to Biological Research, Infectious diseases and Epidemics in Low-income countries (GABRIEL network).

    abstract:BACKGROUND:Data on the etiologies of pneumonia among children are inadequate, especially in developing countries. The principal objective is to undertake a multicenter incident case-control study of <5-year-old children hospitalized with pneumonia in developing and emerging countries, aiming to identify the causative a...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12879-014-0635-8

    authors: Picot VS,Bénet T,Messaoudi M,Telles JN,Chou M,Eap T,Wang J,Shen K,Pape JW,Rouzier V,Awasthi S,Pandey N,Bavdekar A,Sanghvi S,Robinson A,Contamin B,Hoffmann J,Sylla M,Diallo S,Nymadawa P,Dash-Yandag B,Russomando G

    更新日期:2014-12-10 00:00:00

  • Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China.

    abstract:BACKGROUND:Infections by Streptococcus gallolyticus subsp. pasteurianus (SGSP) is often underestimated. Herein, the epidemiological features and resistant characteristics of SGSP in mainland China are characterized to enable a better understanding of its role in clinical infections. METHODS:In the present work, 45 SGS...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-019-4413-5

    authors: Li Y,Chen X,Zhang Z,Wang L,Wang J,Zeng J,Yang J,Lu B

    更新日期:2019-09-09 00:00:00

  • Is the tide turning again for cephalosporin resistance in Neisseria gonorrhoeae in Europe? Results from the 2013 European surveillance.

    abstract:BACKGROUND:The emerging resistance to the extended-spectrum cephalosporins (ESCs) in Neisseria gonorrhoeae together with increasing incidence of gonorrhoea cases in many countries have been global public health concerns. However, in recent years the levels of ESC resistance have decreased in several regions worldwide. ...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-015-1013-x

    authors: Cole MJ,Spiteri G,Jacobsson S,Pitt R,Grigorjev V,Unemo M,Euro-GASP Network.

    更新日期:2015-08-11 00:00:00

  • Healthcare-associated infections: bacteriological characterization of the hospital surfaces in the University Hospital of Abomey-Calavi/so-ava in South Benin (West Africa).

    abstract:BACKGROUND:Healthcare-associated infections have become a public health problem, creating a new burden on medical care in hospitals. The emergence of multidrug-resistant bacteria poses a difficult task for physicians, who have limited therapeutic options. The dissemination of pathogens depends on "reservoirs", the diff...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/s12879-018-3648-x

    authors: Afle FCD,Agbankpe AJ,Johnson RC,Houngbégnon O,Houssou SC,Bankole HS

    更新日期:2019-01-07 00:00:00

  • Detection of hydrogen peroxide-producing Lactobacillus species in the vagina: a comparison of culture and quantitative PCR among HIV-1 seropositive women.

    abstract:BACKGROUND:The presence of hydrogen peroxide (H(2)O(2)) producing Lactobacillus in the vagina may play a role in controlling genital HIV-1 shedding. Sensitive molecular methods improve our ability to characterize the vaginal microbiota; however, they cannot characterize phenotype. We assessed the concordance of H(2)O(2...

    journal_title:BMC infectious diseases

    pub_type: 杂志文章

    doi:10.1186/1471-2334-12-188

    authors: Balkus JE,Mitchell C,Agnew K,Liu C,Fiedler T,Cohn SE,Luque A,Coombs R,Fredricks DN,Hitti J

    更新日期:2012-08-13 00:00:00