abstract：:Lipoprotein lipase (LPL) is a secreted triglyceride lipase involved in the clearance of very-low-density lipoproteins and chylomicrons from circulation. LPL is expressed primarily in adipose and muscle tissues and transported to the capillary lumen. LPL secretion is regulated by insulin in adipose tissue; however, few...

authors： Roberts BS,Yang CQ,Neher SB

更新日期：2022-03-01 00:00:00

abstract：:The dying-back hypothesis holds that the damage to neuromuscular junctions and distal axons in amyotrophic lateral sclerosis occurs at the earliest stage of the disease. Previous basic studies have confirmed early damage to neuromuscular junctions, but it is difficult to obtain such evidence directly in clinical pract...

authors： Ma JY,Liu XY,Zhang S,Fan DS

更新日期：2022-03-01 00:00:00

abstract：:MicroRNA-491-5p (miR-491-5p) plays an important role in regulating cell proliferation and migration; however, the effect of miR-491-5p on neovascularization after traumatic brain injury remains poorly understood. In this study, a controlled cortical injury model in C57BL/6 mice and an oxygen-glucose deprivation model ...

authors： Tang W,Guo ZD,Chai WN,Du DL,Yang XM,Cao L,Chen H,Zhou C,Cheng CJ,Sun XC,Huang ZJ,Zhong JJ

更新日期：2022-03-01 00:00:00

abstract：:Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich wa...

authors： Lin YT,Shi QQ,Zhang L,Yue CP,He ZJ,Li XX,He QJ,Liu Q,Du XB

更新日期：2022-02-01 00:00:00

abstract：:Cholesterol is biosynthesized by all animal cells. Beyond its metabolic role in steroidogenesis, it is enriched in the plasma membrane where it has key structural and regulatory functions. Cholesterol is thus presumably important for post-injury axon regrowth, and this notion is supported by studies showing that impai...

authors： Tang BL

更新日期：2022-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are 20-24-nucleotide-long noncoding RNAs that bind to the untranslated region (3' UTR) of their target mRNAs. The importance of miRNAs in medicine has grown rapidly in the 20 years since the discovery of them. As the regulatory function of miRNAs on biological processes was discovered, they were adv...

authors： Karagur ER,Akgun S,Akca H

更新日期：2022-01-01 00:00:00

abstract：:Just as in eukaryotes, high-throughput chromosome conformation capture (Hi-C) data have revealed nested organizations of bacterial chromosomes into overlapping interaction domains. In this chapter, we present a multiscale analysis framework aiming at capturing and quantifying these properties. These include both stand...

authors： Varoquaux N,Lioy VS,Boccard F,Junier I

更新日期：2022-01-01 00:00:00

abstract：:In this era of big data, sets of methodologies and strategies are designed to extract knowledge from huge volumes of data. However, the cost of where and how to get this information accurately and quickly is extremely important, given the diversity of genomes and the different ways of representing that information. Am...

authors： de Amorim TS,Pedro DLF,Paschoal AR

更新日期：2022-01-01 00:00:00

abstract：:The year 2020 was characterized by the COVID-19 pandemic that has caused, by the end of March 2021, more than 2.5 million deaths worldwide. Since the beginning, besides the laboratory test, used as the gold standard, many applications have been applying deep learning algorithms to chest X-ray images to recognize COVID...

authors： Guarrasi V,D'Amico NC,Sicilia R,Cordelli E,Soda P

更新日期：2022-01-01 00:00:00

abstract：Background:The emergence of carbapenemase-producing Enterobacteriaceae (CPE) represents a major clinical problem. Recently, the occurrence of CPE has increased globally, but epidemiological patterns vary across region. We report the trends in the genotypic distribution and antimicrobial susceptibility of CPE isolated f...

authors： Jeong S,Lee N,Park MJ,Jeon K,Kim HS,Kim HS,Kim JS,Song W

更新日期：2022-01-01 00:00:00

abstract：:Missing data is a common, difficult problem for network studies. Unfortunately, there are few clear guidelines about what a researcher should do when faced with incomplete information. We take up this problem in the third paper of a three-paper series on missing network data. Here, we compare the performance of differ...

authors： Smith JA,Morgan JH,Moody J

更新日期：2022-01-01 00:00:00

abstract：:Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions, such as antioxidation, neuroprotection, and immune modulation. One of the main mechanisms of Alzheimer's disease is that microglia activated by amyloid beta (Aβ) transform from the resti...

authors： Sun ZQ,Liu JF,Luo W,Wong CH,So KF,Hu Y,Chiu K

更新日期：2022-01-01 00:00:00

abstract：:Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency of β-hexosaminidase A (HexA) enzyme, which results in the accumulation of GM2 gangliosides in the nervous system cells. In this work, we analyzed the efficacy and safety of cell-mediated gene therapy for San...

authors： Shaimardanova AA,Chulpanova DS,Solovyeva VV,Aimaletdinov AM,Rizvanov AA

更新日期：2022-01-01 00:00:00

abstract：:There is an increasing recognition of the strong links between the gut microbiome and the brain, and there is persuasive evidence that the gut microbiome plays a role in a variety of physiological processes in the central nervous system. This review summarizes findings that gut microbial composition alterations are li...

authors： Liu C,Yang SY,Wang L,Zhou F

更新日期：2022-01-01 00:00:00

abstract：AIM:To compare the acute effects of two resistance exercise sessions with different partial blood flow restrictions (BFR) on hemodynamic parameters and cardiac autonomic modulation in older women with metabolic syndrome. METHODS:Thirty-nine older women (64.4 ± 4.5 years) were allocated into three groups: BFR0 = resist...

authors： Maciel AWS,Pinto LM,Campos RCA,Ferreira AC,Dias-Filho CAA,Dias CJM,Pires FO,Urtado CB,Rodrigues B,Mostarda CT

更新日期：2021-12-29 00:00:00

abstract：:The current COVID-19 pandemic, that has caused more than 100 million cases as well as more than two million deaths worldwide, demands the development of fast and accurate diagnostic methods despite the lack of available samples. This disease mainly affects the respiratory system of the patients and can lead to pneumon...

authors： Morís DI,de Moura Ramos JJ,Buján JN,Hortas MO

更新日期：2021-12-15 00:00:00

abstract：:The prevalence of unconventional oil and gas (UOG) operations raises concerns regarding the potential for adverse health outcomes following exposure to water tainted by mixtures of UOG associated chemicals. The potential effects that exposure to complex chemical mixtures has on the immune system have yet to be fully e...

authors： O'Dell CT,Boule LA,Robert J,Georas SN,Eliseeva S,Lawrence BP

更新日期：2021-12-01 00:00:00

abstract：:A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines and the protozoan parasite Trypanosoma brucei. The influence of the type of amidino substitu...

authors： Racané L,Rep V,Kraljević Pavelić S,Grbčić P,Zonjić I,Radić Stojković M,Taylor MC,Kelly JM,Raić-Malić S

更新日期：2021-12-01 00:00:00

abstract：:Since December 2019, the COVID-19 pandemic has rapidly emerged on a global scale. Many factors have influenced the spread of COVID-19. This research studies the sociodemographic and environmental health risk factors associated with COVID-19. The study used an ecological study design with subdistricts as its unit of an...

authors： Zakianis,Adzania FH,Fauzia S,Aryati GP,Mahkota R

更新日期：2021-12-01 00:00:00

abstract：:This research aimed to explore the biological role of long non-coding RNA (lncRNA) ZFAS1 in bupivacaine-induced neurotoxicity. The levels of lncRNA ZFAS1, miR-421, and zinc finger protein 564 (ZNF564) were detected by RT-qPCR. MTT and TUNEL assays were utilized to evaluate cell viability and apoptosis, respectively. C...

authors： Yuan L,Xu H,Guo R,Lu T,Li X

更新日期：2021-12-01 00:00:00

abstract：:Methotrexate (MTX) is one of the main therapeutic agents currently used for the prophylaxis of graft-versus-host disease (GvHD) following hematopoietic stem cell transplantation. However, it is associated with significant toxicity and considerable side effects in many patients, which lead to either early withdrawal or...

authors： AlJohani NI

更新日期：2021-12-01 00:00:00

abstract：:Kimchi is one of the primary sources of high sodium content in the Korean diet. Low-sodium kimchi is commercially manufactured to minimize the health effects of high salt. We investigated the influence of lactic acid bacteria (LAB) as starter culture in combination with 1% or 2.5% salt on the survival of pathogenic Es...

authors： Choi SJ,Yang SY,Yoon KS

更新日期：2021-12-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world. Naproxen is an NSAID with relatively low selectivity for cyclooxygenase-2 (COX-2), thereby having decreased risk for cardiovascular (CV) events. However, it is unclear whether naproxen might provide protection agai...

authors： Wu Y,Hao R,Lan B,Mu Y,Dang F,Wang R

更新日期：2021-12-01 00:00:00

abstract：:This study was carried out with the objective to identify function prediction of novel microRNAs (miRNAs) in immature boar Sertoli cells (SCs) treated with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR), which is an agonist of adenosine monophosphate-activated protein kinase (AMPK) for regulating cellular...

authors： Zhang JJ,Wang YS,Li YQ,Chen L,Wang XZ

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:In March 2020, the WHO declared the SARS CoV-2 pandemic. This had an immediate and dramatic impact on Romanian physicians. OBJECTIVES:To analyse SARS-CoV-2 risk perception among Romanian physicians following the official WHO pandemic announcement. METHODS:A questionnaire was sent to Romanian physicians (n ...

authors： Herdea V,Duduciuc A,Ghionaru R,Comnea L,Păduraru L,Diaconescu S

更新日期：2021-12-01 00:00:00

abstract：:The management of bacterial infections, especially trains of methicillin-resistant Staphylococcus aureus observe in health care settings, has markedly improved with the introduction of established drugs but using newer nano-based formulations. This study investigates the effects of vancomycin-linoleic acid nanoparticl...

authors： Naidu ECS,Olojede SO,Lawal SK,Peter AI,Akang EA,Azu OO

更新日期：2021-12-01 00:00:00

abstract：:Granulosa cells (GCs) play an important role in the development of follicles. In this study, we investigate the impact of heat stress at 41°C and 43°C on duck GCs' proliferation and steroids secretion. And, the transcriptomic responses to heat treatment were examined using RNA-sequencing analysis. Digital gene express...

authors： Yang C,Huang XB,Chen SJ,Li XJ,Fu XL,Xu DN,Tian YB,Liu WJ,Huang YM

更新日期：2021-12-01 00:00:00

abstract：:The quinolone resistance crpP genes can mediate decreased susceptibility to quinolones. However, diversification and prevalence of crpP genes and crpP-carrying integrative and conjugative elements (ICEs) still need to be elucidated. In this study, genome sequencing was conducted for 200 Chinese Pseudomonas aeruginosa ...

authors： Zhu Z,Yang H,Yin Z,Jing Y,Zhao Y,Fu H,Du H,Zhou D

更新日期：2021-12-01 00:00:00

abstract：:Angiotensin converting enzyme-2 (ACE2) is the cell-surface receptor enabling cellular entry of SARS-CoV-2. ACE2 is highly expressed in adipose tissue (AT), rendering AT a potential SARS-CoV-2 reservoir contributing to massive viral spread in COVID-19 patients with obesity. Although rodent and cell studies suggest that...

authors： de Ligt M,Hesselink MKC,Jorgensen J,Hoebers N,Blaak EE,Goossens GH

更新日期：2021-12-01 00:00:00

abstract：:Formononetin (FMNT), a flavonoid identified from the Chinese herb Astragalus membranaceus, possesses anti-inflammatory or anti-oxidative properties in different human diseases. This study aims to comprehensively elucidate the function of FMNT in atherosclerosis and its underlying mechanisms. Online public databases we...

authors： Zhang B,Hao Z,Zhou W,Zhang S,Sun M,Li H,Hou N,Jing C,Zhao M

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:Sexual and gender minority youth (SGMY) experience unique challenges related to identity and disclosure, and cope in vibrant ways. Qualitative research has not yet fulsomely explored the risk, resilience, and identity intersections that impact vulnerable SGMY wellbeing. Methods: This digital photo-elicitation s...

authors： Craig SL,Eaton AD,Kirkland A,Egag E,Pascoe R,King K,Krishnan S

更新日期：2021-12-01 00:00:00

abstract：:Stroke is a main cause of disability and death worldwide, and ischemic stroke accounts for most stroke cases. Recently, microRNAs (miRNAs) have been verified to play critical roles in the development of stroke. Herein, we explored effects of miR-152-3p on vascular endothelial cell functions under hypoxia. Human umbili...

authors： Zhao Z,Wu C,He X,Zhao E,Hu S,Han Y,Wang T,Chen Y,Liu T,Huang S

更新日期：2021-12-01 00:00:00

abstract：:Ustilaginoidea virens, causing rice false smut (RFS) is an economically important ascomycetous fungal pathogen distributed in rice-growing regions worldwide. Here, we identified a novel transcription factor UvCGBP1 (Cutinase G-box binding protein) from this fungus, which is unique to ascomycetes. Deletion of UvCGBP1 a...

authors： Chen X,Li P,Liu H,Chen X,Huang J,Luo C,Li G,Hsiang T,Collinge DB,Zheng L

更新日期：2021-12-01 00:00:00

abstract：:Nitrous Oxide (N2O) has been shown to be neurotoxic, but its specific mechanism is still unclear. The purpose of this work is to probe into the impact of N2O on nerve cell injury through regulating thioredoxin-interacting protein (TXNIP)/the NOD-like receptor domain of pyrin containing 3 (NLRP3) pathway. The results i...

authors： Liu W,Zhang G,Sun B,Wang S,Lu Y,Xie H

更新日期：2021-12-01 00:00:00

abstract：:The Vaccinium genus comprises more than 126 genera of perennial flowering plants that are commonly adapted to poor and acidic soils or epiphytic environments. Their molecular and genomic characterization is a result of the recent advent in next-generation sequencing technology. In the current research, extracts were p...

authors： Rasool M,Malik A,Abdul Basit Ashraf M,Mubbin R,Ayyaz U,Waquar S,Asif M,Umar M,Siew Hua G,Iqbal Z,Alam H,Achakzai NM

更新日期：2021-12-01 00:00:00

abstract：:Dental caries is the most common chronic childhood disease in Canada and creates a significant burden on both human and financial costs. In Canada, the annual cost of dental day surgery for children is $21.2 million. The objective of this study was to explore and address the strengths and barriers related to the provi...

authors： Ogenchuk M,St Pierre R,Uswak G,Graham H,Weiler R,Ramsden VR

更新日期：2021-12-01 00:00:00

abstract：:Malignant tumors are a serious threat to human health. Surgical resection is the most effective treatment for liver cancer. However, liver cancer is mostly found at an advanced stage, is difficult to remove by surgery, and has a very high recurrence rate after surgery. The current liver cancer treatment drugs have ser...

authors： Li Z,Liu H,Zhang Y,Tan H

更新日期：2021-12-01 00:00:00

abstract：:Ruminants are not considered to experience nausea because they do not possess the emetic reflex. This study examined the effects of administration of cisplatin (cis-diamminedichloro platinum (II): CDDP), a common emetic agent, on the behavior of goats. In Experiment 1, adult Shiba goats received intravenous (IV) admin...

authors： Aoyama M,Shioya M,Tsukamoto Y,Hasegawa H,Sugita S

更新日期：2021-12-01 00:00:00

abstract：:The Sámi Indigenous populations, who live in the arctic Sápmi area across four countries - Norway, Sweden, Finland and the Kola Peninsula of Russia - have practiced traditional medicine (TM) for millennia. However, today Sámi TM is unknown within the Swedish health care services (HCS). The aim of this study is to desc...

authors： Liu-Helmersson J,Ouma A

更新日期：2021-12-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common malignancies worldwide. Despite rapid advances in systemic therapy, GC remains the third leading cause of cancer-related deaths. We aimed to identify a novel prognostic signature associated with FAT2 mutations in GC. We analyzed the expression levels of FAT2-mutant and FAT...

authors： Zhou L,Yang Y,Liu M,Gan Y,Liu R,Ren M,Zheng Y,Wang Y,Zhou Y

更新日期：2021-12-01 00:00:00